17 completed, 4 terminated, 3 unknown, 2 recruiting. 11 Not applicable, 8 Phase 4, 5 Phase 3, 3 Phase 2, 2 Early Phase 1.
Follow this drug Literature Review of Sennosides trials Research Report on Sennosides
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Senna vs. Polyethylene Glycol 3350 for the Treatment of Retentive Encopresis in Children PEG 3350, Senna - Encopresis With Constipation and Overflow Incontinence | Early Phase 1 | Not yet recruiting | Shaare Zedek Medical Center | 80 | 2026-07-01 | 2026-06-18 |
| PEG3350 vs Senna After Urogyn Surgery Senna, Polyethylene glycol 3350 - Obstructive Defecation Syndrome, Postoperative Constipation | Phase 4 | Recruiting | St. Joseph's Health, New York | 254 | 2025-04-23 | 2025-05-28 |
| Whatsapp Based Patient Education to Improve Bowel Preparation for Colonoscopy Standard bowel preparation instructions, Polyethylene glycol with senna - To Access Quality of Bowel Preparation | Not applicable | Completed | Shaukat Khanum Memorial Cancer Hospital & Research Centre | 110 | 2025-03-23 | 2026-08-24 |
| Optimization of Postoperative Bowel Habits Senna Tab, Dulcolax Suppositories - Constipation | Not applicable | Recruiting | Wake Forest University Health Sciences | 88 | 2024-10-16 | 2026-02-27 |
| Gut Microbiome and Blood Markers After Habitual Herbal Tea Consumption TeTrimTeas welsh Herbal tea with rhubarb root, TeTrimTeas welsh Herbal tea with senna, TeTrimTeas welsh Herbal tea with green tea - Obesity, Well-being | Early Phase 1 | Unknown | Aberystwyth University | 55 | 2022-11-17 | 2023-05-17 |
| Bowel Preparation in Elective Pediatric Colorectal Surgery Senna, Sodium Picosulfate, Magnesium Oxide and Citric Acid, Metronidazole Oral - Colostomy, Hirschsprung Disease - Pull Through | Not applicable | Unknown | McMaster University | 81 | 2022-01-01 | 2021-12-09 |
| RELISTOR's Effects on Opioid-Induced Constipation Relistor Injectable Product, Docusate Calcium, Bisacodyl - OIC | Withdrawn | Methodist Health System | 2021-07-01 | 2026-03-23 | ||
| Peritoneal Dialysis Pilot Study: Evaluating Polyethylene Glycol (PEG) for Constipation Current Bowel Protocol (senna/lactulose), PEG Bowel Protocol (PEG/lactulose) - Constipation, Peritoneal Dialysis Complication | Phase 4 | Completed | Nova Scotia Health Authority | 25 | 2017-07-07 | 2024-08-21 |
| Gut Transit Effect on Enterohepatic Circulation Loperamide, Senna - Intestinal Transit | Not applicable | Completed | University Hospital Plymouth NHS Trust | 19 | 2017-04-10 | 2022-09-30 |
| Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids Naloxegol Oral Tablet, Placebo Oral Tablet, Docusate Sodium 100 Mg oral capsule [Colace] - Constipation | Phase 4 | Terminated | Tufts Medical Center | 12 | 2017-01-01 | 2023-02-16 |
| Breathlessness Exertion and Morphine Sulphate Placebo, Morphine Sulfate, Plus laxative (Docusate with senna) - Chronic Obstructive Pulmonary Disease, Dyspnea | Phase 3 | Completed | Flinders University | 171 | 2016-08-08 | 2020-02-11 |
| The Use of Sennosides With Pico Salax in Bowel Preparation for Colonoscopy: a Study of Optimal Dose and Timing Sennosides - Colonoscopy Preparation Outcome | Not applicable | Completed | Queen's University | 100 | 2016-01-01 | 2018-05-09 |
| Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure PillCam® COLON 2 procedure-CONTROL, Senna tablets, PEG - Colorectal Cancer Screening | Not applicable | Completed | Medtronic - MITG | 122 | 2015-05-01 | 2017-03-07 |
| Adding Stewed Apricot Juice to Senna Improves the Right-Side and Overall Colon Cleansing Quality for Colonoscopy Preparation Senna and stewed apricot juice, Senna alone - Colonoscopy Preparation | Phase 4 | Completed | Camlıca Erdem Hospital | 128 | 2015-04-01 | 2016-01-28 |
| An Interdisciplinary Approach to the Treatment of Encopresis in Children With Autism Spectrum Disorders Glycerin Suppository, Bisacodyl suppository, Senna - Encopresis, Autistic Disorder | Not applicable | Completed | Emory University | 22 | 2015-02-01 | 2018-07-02 |
| Efficacy of Linaclotide to Senna for CIC Senna, Linzess - Chronic Idiopathic Constipation | Not applicable | Terminated | TriHealth Inc. | 9 | 2014-09-01 | 2019-07-02 |
| A Double-blinded,Double-dummy Clinical Trial of Chinese Herbal Medicine (MaZiRenWan) for Functional Constipation MZRW, Senna, placebo - Functional Constipation, Gastrointestinal Disorders | Phase 2 | Completed | Hong Kong Baptist University | 291 | 2013-06-01 | 2020-05-12 |
| Methylnaltrexone Use for Opioid-induced Postoperative Constipation Methylnaltrexone, Senna, docusate sodium, bisacodyl, magnesium hydroxide, Miralax - Constipation | Phase 4 | Completed | Shriners Hospitals for Children | 60 | 2013-05-01 | 2015-05-19 |
| Evaluating the Effect of Senna in Uremic Pruritus Senna, Placebo - End Stage Renal Disease, Pruritus | Not applicable | Completed | Shiraz University of Medical Sciences | 60 | 2011-08-01 | 2015-04-01 |
| PEG Versus PEG+Bisacodyl Versus Sennosides for Colon Cleansing Before Colonoscopy polyethylene glycol +Bisacodyl, Polyethylene glycol, Sennosides - Colonoscopy Preparation | Phase 4 | Completed | Medical University of Warsaw | 240 | 2010-11-01 | 2012-02-10 |
Showing 20 of 29. Sign in to see all of them.
Constipation (11) · Anemia, Refractory (1) · Autistic Disorder (1) · Behavioral Symptoms (1) · Burkitt Lymphoma (1) · Child Development Disorders, Pervasive (1) · Dyspnea (1) · Encopresis (1) · Enterocolitis, Necrotizing (1) · Fecal Incontinence (1) · Gastrointestinal Diseases (1) · Gastrointestinal Hemorrhage (1) · Inflammatory Bowel Diseases (1) · Intestinal Obstruction (1) · Kidney Failure, Chronic (1)
Aberystwyth University (1) · British Columbia Cancer Agency (1) · Camlıca Erdem Hospital (1) · Children's Hospital of Philadelphia (1) · Emory University (1) · Flinders University (1) · Hong Kong Baptist University (1) · London North West Healthcare NHS Trust (1) · Marjan Industria e Comercio ltda (1) · McMaster University (1) · Medical University of Warsaw (1) · Medtronic - MITG (1) · Methodist Health System (1) · National Cancer Institute (NCI) (1) · Nova Scotia Health Authority (1)
United States (11) · Canada (4) · United Kingdom (3) · Brazil (2) · Australia (1) · China (1) · Israel (1) · New Zealand (1) · Pakistan (1) · Poland (1) · Sweden (1)
Abdolali Mohagheghzadeh, PhD (1) · Arian Kamali-Sarvestani, Pharm D (1) · Candace Parker-Autry, MD (1) · Christina M Marciniak, MD (1) · Christopher Fraser, MB BCH, MD, FRCP (1) · David C Currow, MD, PhD (1) · Deborah J. Vermaire, M.D. (1) · Douglas K Rex, Dr. (1) · Erik Garpestad, MD (1) · Jaclyn Y Tran, BScPharm (1) · Jaderson Lima, Study Director (1) · Jamshid Roozbeh, MD (1) · Jaroslaw Kierkus, MD (1) · Keila S Muniz, MD (1) · Lawrence Hookey (1)
PMID 10968848, PMID 12085041, PMID 19555936, PMID 20812020, PMID 21998076, PMID 22699838, PMID 23574119, PMID 24180235, PMID 24224624, PMID 25024303, PMID 25473191, PMID 28716797, PMID 29654915, PMID 29748435, PMID 30125215, PMID 32375747, PMID 33283264, PMID 34432874, PMID 35764027, PMID 35882475, PMID 36413230, PMID 38477675, PMID 38796500, PMID 40015533, PMID 40269943