37 completed, 5 withdrawn, 3 terminated, 3 unknown. 14 Phase 1, 13 Phase 4, 12 Phase 3, 9 Phase 2, 3 Not applicable.
Follow methylnaltrexone: new trials by email Literature Review of methylnaltrexone trials Research Report on methylnaltrexone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methylnatrexone In Resectable Head and Neck Squamous Cell Carcinoma (MINK). A "Window of Opportunity" Pilot Study. Methylnaltrexone - Head and Neck Squamous Cell Carcinoma | Phase 4 | Recruiting | M.D. Anderson Cancer Center | 25 | 2024-01-10 | 2026-06-10 |
| Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics Relistor Injectable Product - Chronic Widespread Pain | Not applicable | Recruiting | Florida International University | 200 | 2021-11-15 | 2026-09-11 |
| Methylnaltrexone vs Naloxegol in the Treatment of Opioid-Induced Constipation Methylnaltrexone Bromide 150 mg Oral Tablet, Methylnaltrexone Bromide 12 MG/0.6 ML Subcutaneous Solution [RELISTOR]_#1, Naloxegol 25 MG Oral Tablet - Constipation Drug Induced | Phase 4 | Completed | University of Missouri-Columbia | 15 | 2020-12-23 | 2024-09-19 |
| An Extension Study of Methylnaltrexone Bromide (MNTX) in Participants With Advanced Pancreatic Cancer Methylnaltrexone bromide (MNTX) - Pancreatic Cancer | Phase 3 | Withdrawn | Bausch Health Americas, Inc. | 2020-02-03 | 2021-05-07 | |
| A Study of Methylnaltrexone Bromide (MNTX) in Participants With Advanced Pancreatic Cancer Methylnaltrexone bromide, Placebo - Pancreatic Cancer | Phase 2 / Phase 3 | Withdrawn | Bausch Health Americas, Inc. | 2020-01-06 | 2021-05-07 | |
| Subcutaneous Methylnaltrexone Versus Placebo for Postoperative Ileus Prevention Methylnaltrexone, Placebo - Postoperative Ileus | Phase 2 | Completed | Ohio State University | 82 | 2019-02-21 | 2021-10-27 |
| Opioid-Induced Swallowing Dysfunction - The Impact of Bolus Volume RemifentanilMNTX, PlaceboMNTX - Pharyngeal Dysfunction, Pharyngeal Swallowing | Phase 4 | Unknown | Region Örebro County | 20 | 2017-11-11 | 2017-12-12 |
| Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids Naloxegol Oral Tablet, Placebo Oral Tablet, Docusate Sodium 100 Mg oral capsule [Colace] - Constipation | Phase 4 | Terminated | Tufts Medical Center | 12 | 2017-01-01 | 2023-02-16 |
| Methylnaltrexone as a Method to Improve Ticagrelor Uptake in Morphine Treated STEMI Patients Methylnaltrexone bromide (Relistor®)., Sodium Chloride 9mg/mL - STEMI, Morphine | Phase 4 | Completed | Karolinska University Hospital | 82 | 2016-11-01 | 2018-04-09 |
| Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine Methylnaltrexone, Placebo, Morphine - Coronary Artery Disease | Phase 4 | Completed | University of Florida | 30 | 2015-08-01 | 2017-05-30 |
| Study of Methylnaltrexone in Opioid-Induced Constipation Patients Methylnaltrexone (MNTX), Placebo - Opioid-induced Constipation | Phase 2 / Phase 3 | Unknown | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 198 | 2015-04-01 | 2015-10-14 |
| Methylnaltrexone Pharmacokinetics in Neurointensive Care Patients Methylnaltrexone - Opioid Use, Unspecified With Other Opioid-induced Disorder | Phase 1 | Completed | University of Zurich | 9 | 2014-02-01 | 2016-10-26 |
| The Effect of Naloxone and Methylnaltrexone on Esophageal Sensitivity in Health Naloxone, Methylnaltrexone Bromide, Placebo - Endogenous and Esophageal Sensitivity | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 12 | 2013-10-01 | 2017-01-09 |
| Methylnaltrexone Use for Opioid-induced Postoperative Constipation Methylnaltrexone, Senna, docusate sodium, bisacodyl, magnesium hydroxide, Miralax - Constipation | Phase 4 | Completed | Shriners Hospitals for Children | 60 | 2013-05-01 | 2015-05-19 |
| Methylnaltrexone for Opioid Induced Constipation methylnaltrexone - Constipation | Terminated | Amsterdam UMC, location VUmc | 7 | 2012-07-01 | 2019-08-05 | |
| Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time. Loperamide placebo, Loperamide, Colon Transit - Intestinal Obstruction | Phase 1 | Completed | University Medicine Greifswald | 16 | 2011-05-01 | 2012-05-11 |
| Effect of Methylnaltrexone (Relistor) on Digestion and Tolerance to Tube Feeding in Patients Treated With Opiates Methylnaltrexone, Saline injection - Tube Feeding | Phase 3 | Withdrawn | Drexel University | 2010-10-01 | 2015-03-17 | |
| A Study of Oral Methylnaltrexone (MNTX) for the Treatment of Opioid-Induced Constipation (OIC) in Participants With Chronic, Non-Malignant Pain Methylnaltrexone, Placebo - Opioid-Induced Constipation | Phase 3 | Completed | Bausch Health Americas, Inc. | 804 | 2010-09-01 | 2019-09-06 |
| Evaluate the Pharmacokinetics (PK) of Methylnaltrexone (MNTX) in Healthy Adult Subjects Methylnaltrexone bromide - Healthy Adult Subjects | Phase 1 | Completed | Bausch Health Americas, Inc. | 20 | 2010-07-01 | 2019-11-29 |
| Methylnaltrexone vs Erythromycin for Facilitating Gastric Emptying Time in Critically Ill Patients Erythromycin, Methylnaltrexone - Gastroparesis | Phase 2 | Terminated | Shiraz University of Medical Sciences | 42 | 2010-05-01 | 2011-03-31 |
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Constipation (11) · Opioid-Induced Constipation (10) · Ileus (2) · Intestinal Obstruction (2) · Pancreatic Neoplasms (2) · Chronic Pain (1) · Coronary Artery Disease (1) · Esophageal Diseases (1) · Gastroesophageal Reflux (1) · Gastroparesis (1) · Hernia (1) · Neoplasms (1) · Opioid-Related Disorders (1) · Renal Insufficiency (1) · ST Elevation Myocardial Infarction (1)
Bausch Health Americas, Inc. (28) · Region Örebro County (2) · University Medicine Greifswald (2) · Amsterdam UMC, location VUmc (1) · Beth Israel Medical Center (1) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (1) · Drexel University (1) · Florida International University (1) · Karolinska University Hospital (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · Ohio State University (1) · Shiraz University of Medical Sciences (1) · Shriners Hospitals for Children (1) · St. John Health System, Michigan (1)
United States (37) · Germany (6) · Australia (5) · Canada (5) · Italy (4) · South Korea (4) · Sweden (4) · Belgium (3) · France (3) · Spain (3) · Hungary (2) · Mexico (2) · Netherlands (2) · Poland (2) · South Africa (2)
Tage Ramakrishna, MD (13) · Lindsey Mathew (6) · Enoch Bortey (3) · Jeff Cohn (3) · John Lahey (2) · Bradford A Whitmer, D.O. (1) · Deborah J. Vermaire, M.D. (1) · Dominick Angiolillo (1) · Erik Garpestad, MD (1) · Henk WM Verheul, MD, PhD (1) · Jan Tack, MD, PhD (1) · Johanna Savilampi, MD, PhD (1) · Juan Cata, MD (1) · Lemeneh Tefera, MD (1)
PMID 33788162, PMID 21471758, PMID 21998076, PMID 20839388, PMID 21429809, PMID 21810165, PMID 23713743, PMID 25165428, PMID 26150678, PMID 26312011, PMID 27573565, PMID 27628064, PMID 30636504, PMID 30922276, PMID 31377269, PMID 34798295