65 completed, 53 unknown, 38 recruiting, 18 active not recruiting. 66 Not applicable, 20 Phase 2, 13 Phase 4, 12 Phase 3, 10 Phase 1.
Follow Cirrhosis, Liver: new trials by email Literature Review of Cirrhosis, Liver trials Research Report on Cirrhosis, Liver
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Erlotinib for Hepatocellular Carcinoma Chemoprevention erlotinib hydrochloride, Placebo - Cirrhosis, Liver, Advanced Liver Fibrosis | Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 60 | 2026-12-01 | 2026-06-24 |
| Patients With Primary Biliary Cholangitis(PBC) Primary Biliary Cholangitis, Liver Fibrosis | Active not recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 30 | 2026-05-18 | 2026-06-05 | |
| Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up) Cirrhosis, Liver, Splenectomy; Status | Not yet recruiting | Northern Jiangsu People's Hospital | 30 | 2026-05-01 | 2026-05-18 | |
| Effect of LSD on Lipid Profiles in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up) Cirrhosis, Liver, Splenectomy; Status | Not yet recruiting | Northern Jiangsu People's Hospital | 30 | 2026-05-01 | 2026-05-14 | |
| Effect of Babao Dan Capsule Combined With Antiviral Therapy on the Incidence of Hepatocellular Carcinoma in Patients With Hepatitis B-related Cirrhosis Babao Dan Capsule, Babao Dan Capsule simulant - HEPATITIS B CHRONIC, Cirrhosis, Liver | Not applicable | Not yet recruiting | Nanfang Hospital, Southern Medical University | 1034 | 2026-04-01 | 2026-04-22 |
| Effect of Fufang Biejiaruangan Combined With Antiviral Therapy on the Incidence of Hepatocellular Carcinoma in Patients With Hepatitis B-related Cirrhosis: A Multicenter, Randomized, Placebo-controlled Study Biejia-Ruangan compound, Biejia-Ruangan compound simulant - Cirrhosis, Liver, Hepatocellular Carcinoma (HCC) | Not applicable | Not yet recruiting | Nanfang Hospital, Southern Medical University | 1034 | 2026-04-01 | 2026-03-18 |
| Cirrhotic and Non-cirrhotic Patients With Clinically Significant Portal Hypertension Cirrhosis, Liver, Portal Hypertension | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 2500 | 2026-02-01 | 2026-02-12 | |
| Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis POCUS, Fixed Resuscitation Strategy based on Target MAP - Cirrhosis, Liver, Cirrhotic Cardiomyopathy | Not applicable | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 140 | 2026-01-01 | 2025-12-16 |
| Changes in Bile Acids and Microbiota in Patients With Hepatitis D Treated With Bulvertide HBV, HBV Coinfection | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 20 | 2025-09-24 | 2026-02-24 | |
| Diagnosis of Lymphohistiocytic Hemophagocytosis in Intensive Care Hepatic Insufficiency, Cirrhosis, Liver | Recruiting | University Hospital, Strasbourg, France | 100 | 2025-08-29 | 2026-01-15 | |
| The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial Commensal Bacteria Strains - Liver Diseases, Liver Failure | Phase 1 | Recruiting | University of Chicago | 24 | 2025-08-04 | 2025-11-04 |
| Carvedilol + Simvastatin vs. Carvedilol Alone for Cirrhosis and Cirrhotic Cardiomyopathy and Impact on Hepatic Decompensation and Survival Simvastatin 20mg, Carvedilol 3.125 mg - Decompensated Cirrhosis, Cirrhotic Cardiomyopathy | Not applicable | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 260 | 2025-06-10 | 2025-06-08 |
| Evaluation of Non-Invasive Tests for Metabolic Liver Disease Metabolic Associated Fatty Liver Disease, Metabolic Associated Steatotic Liver Disease | Recruiting | Foundation for the National Institutes of Health | 400 | 2025-05-13 | 2026-10-26 | |
| Frequency of Portal Hypertension Among Patient With Cirrhotic Liver With Ultrasound Portal Hypertension diagnostics - Cirrhosis, Liver | Active not recruiting | Superior University | 150 | 2025-03-17 | 2025-07-04 | |
| Utility of ROTEM® for Risk Stratification of Post-Invasive Procedure Hemorrhage in Patients With Cirrhosis (CIR-ROTEM) Rotational thromboelastometry - Cirrhosis, Liver | Recruiting | Instituto de Investigación Marqués de Valdecilla | 330 | 2025-03-01 | 2025-04-03 | |
| Transitional Care Program for Fluid Overload in Cirrhosis Transitional Care Program - Cirrhosis, Liver | Not applicable | Recruiting | Milton S. Hershey Medical Center | 20 | 2025-02-15 | 2026-03-09 |
| Thromboelastography Guided Blood Product Transfusion for Upper Gastrointestinal Bleeding in Cirrhosis Thromboelastography - Cirrhosis, Liver, Coagulopathy | Not applicable | Withdrawn | Vanderbilt University Medical Center | 2025-01-16 | 2024-04-12 | |
| Study of Tremelimumab and Durvalumab (MEDI4736) (T300+D) in Advanced Hepatocellular Carcinomas With Child-Pugh-B Cirrhosis Tremelimumab, Durvalumab - Hepatocellular Carcinoma, Cirrhosis, Liver | Phase 2 | Recruiting | The University of Texas Health Science Center at San Antonio | 32 | 2024-12-02 | 2026-01-06 |
| Ketogenic Diet in MASLD-related cACLD Mediterranean diet, Very Low Ketogenic Diet - Steatohepatitis, Nonalcoholic, Steatosis of Liver | Not applicable | Not yet recruiting | University of Palermo | 50 | 2024-11-01 | 2024-08-05 |
| RTX001 Autologous Engineered Macrophages for Liver Cirrhosis RTX001 - End-stage Liver Disease (ESLD), Cirrhosis, Liver | Phase 1 / Phase 2 | Active not recruiting | Resolution Therapeutics Limited | 30 | 2024-10-15 | 2026-10-05 |
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Liver Cirrhosis (198) · Fibrosis (44) · Hypertension, Portal (27) · Carcinoma, Hepatocellular (22) · Liver Diseases (17) · Non-alcoholic Fatty Liver Disease (14) · Sarcopenia (13) · Ascites (11) · Hepatic Encephalopathy (11) · Acute-On-Chronic Liver Failure (9) · End Stage Liver Disease (7) · Liver Neoplasms (7) · Acute Kidney Injury (6) · Malnutrition (6) · Frailty (5)
Pathological Conditions, Signs and Symptoms (198) · Digestive System Diseases (197) · Pathologic Processes (197) · Liver Diseases (181) · Fibrosis (154) · Hepatic Insufficiency (29) · Liver Failure (26) · Nervous System Diseases (26) · Digestive System Neoplasms (23) · Neoplasms by Site (23) · Adenocarcinoma (22) · Carcinoma (22) · Neoplasms (22) · Neoplasms by Histologic Type (22) · Neoplasms, Glandular and Epithelial (22)
Standard of Care (6) · Albumins (4) · Carvedilol (4) · Terlipressin (4) · Portasystemic Shunt, Transjugular Intrahepatic (3) · Rifaximin (3) · Amino Acids (2) · Blood Specimen Collection (2) · Crystalloid Solutions (2) · Methods (2) · Preoperative Exercise (2) · Probiotics (2) · Somatostatin (2) · Vasopressins (2) · beta-hydroxyisovaleric acid (2)
Post Graduate Institute of Medical Education and Research, Chandigarh (15) · Northern Jiangsu People's Hospital (9) · Institute of Liver and Biliary Sciences, India (7) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (5) · Nanfang Hospital, Southern Medical University (5) · University of Alberta (4) · University of Pennsylvania (4) · Hepatopancreatobiliary Surgery Institute of Gansu Province (3) · Hunter Holmes Mcguire Veteran Affairs Medical Center (3) · Indiana University (3) · Massachusetts General Hospital (3) · The Cleveland Clinic (3) · University of Texas Southwestern Medical Center (3) · Asian Institute of Gastroenterology, India (2) · GlaxoSmithKline (2)
United States (63) · China (28) · India (22) · Italy (13) · Spain (9) · United Kingdom (8) · Canada (7) · France (6) · Germany (5) · Turkey (Türkiye) (5) · Egypt (4) · Israel (4) · Romania (3) · South Korea (3) · Belgium (2)
Guo-Qing Jiang, MD (8) · Elliott Tapper, MD (2) · Francesca Romana Ponziani (2) · Jasmohan Bajaj, MD (2) · Marina Serper, MD, MS (2) · Michael J Vinikoor, MD (2) · Xiaolong Qi, M.D. (2) · .Mohamed Omar, Professor (1) · Abhasnee Sobhonslidsuk, MD (1) · Abigail Smith (1) · Abigail Smith, PhD (1) · Adrian M. Di Bisceglie, M.D. (1) · Alan L Hutchison, MD PhD (1) · Ali Islek, MD (1)
PMID 31342529, PMID 37467180, PMID 10075602, PMID 11267312, PMID 11588440, PMID 12500513, PMID 12942477, PMID 16134766, PMID 16741929, PMID 16799972, PMID 16861970, PMID 18237873, PMID 18261170, PMID 18521503, PMID 18791439, PMID 18848939, PMID 19052125, PMID 19291787, PMID 19302262, PMID 19445938, PMID 19676128, PMID 19747918, PMID 19766643, PMID 19852963, PMID 20070284, PMID 20109575, PMID 20211180, PMID 20362695, PMID 20430194, PMID 20517905, PMID 20564351, PMID 20675008, PMID 20675691, PMID 20849805, PMID 20889211, PMID 20953964, PMID 21083592, PMID 21129375, PMID 21139575, PMID 21157444, PMID 21335007, PMID 21374690, PMID 21376050, PMID 21484318, PMID 21520194, PMID 21699796, PMID 21760886, PMID 21782771, PMID 21829595, PMID 21931376
2019 (2), U24DK130164 (2), 2018 (1), I50HX002903 (1), K01TW009998 (1), K23DA048182 (1), K23DK128567 (1), P20CA252732 (1), P50CA295495 (1), R01DK125783 (1), R03DK122230 (1), R21TR002024 (1), U01DK130113 (1), U01DK130134 (1), U01DK130168 (1)