8 completed, 4 not yet recruiting, 2 recruiting, 2 unknown. 12 Not applicable, 5 Phase 2, 1 Phase 1, 1 Phase 3.
Follow beta-hydroxyisovaleric acid: new trials by email Literature Review of beta-hydroxyisovaleric acid trials Research Report on beta-hydroxyisovaleric acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide Calcium-HMB Plus Vitamin D3, Matching placebo - Type 2 Diabetes Mellitus (T2DM), Sarcopenia | Phase 2 | Not yet recruiting | Vanderbilt University Medical Center | 90 | 2026-12-01 | 2026-08-28 |
| Effect of HMB Supplementation and Vivifrail Exercise on Body Composition, Handgrip Strength and Physical Performance in Women Over 60 Years of Age Calcium β-hydroxy-β-methylbutyrate (HMB-Ca), Maltodextrin (Placebo), Vivifrail multicomponent exercise program - Aging, Muscle Strength | Not applicable | Not yet recruiting | Universidad Autónoma del Estado de Hidalgo | 44 | 2026-12-01 | 2026-10-29 |
| Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease Creatine monohydrate, Beta-hydroxy-beta-methylbutyrate (HMB), Placebo (microcrystalline cellulose) - Huntington Disease, Sarcopenia | Not applicable | Not yet recruiting | Universidad de Burgos | 88 | 2026-11-01 | 2026-10-28 |
| TCM Formula vs. HMB in Pre-Frail Elders: Muscle Strength and Bone Status TCM Formula, HMB (beta-Hydroxy-beta-methylbutyrate) - Pre-Frailty, Sarcopenia | Phase 2 | Active not recruiting | Tri-Service General Hospital (TSGH) | 90 | 2026-04-02 | 2026-11-03 |
| Effects of HMB and Rehabilitation Program in Athletes With Patellar Tendinopathy Eccentric exercise and extracorporeal shock wave therapy, Beta-hydroxy-beta-methylbutyrate (HMB) - Patellar Tendinopathy | Not applicable | Not yet recruiting | Universidad Complutense de Madrid | 30 | 2026-03-01 | 2026-03-12 |
| Influence of β-hydroxy β-methyl Butyrate (HMB)Supplementation on Post-operative Muscle Mass and Function in Female Athletes CaHMB (Dietary supplement, not Drug), CaLa - Atrophy | Phase 2 | Recruiting | University of Kansas Medical Center | 30 | 2023-05-29 | 2026-03-02 |
| HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis Hydroxy Methyl Butyrate, Balanced Amino Acids - Cirrhosis, Liver | Not applicable | Recruiting | The Cleveland Clinic | 24 | 2021-11-30 | 2026-09-28 |
| Beta-Hydroxy-Beta-Methylbutyrate Supplementation and Physical Activity in Liver Cirrhosis: a Controlled Trial BETA-HYDROXY-BETA-METHYLBUTYRATE (HMB), Mannitol - Sarcopenia, Cirrhosis, Liver | Not applicable | Unknown | University of Roma La Sapienza | 40 | 2019-03-01 | 2019-03-27 |
| Can Beta-Hydroxy-beta-Methylbutyrate Supplementation Counteract Muscle Catabolism in Critically Ill Patients? HMB (beta-hydroxy beta-methylbutyrate) - Critical Illness, Muscle Weakness | Not applicable | Completed | Mette M Berger | 37 | 2018-09-17 | 2020-08-21 |
| A Study to Investigate the Effect of HMB on Skeletal Muscle Wasting in Early Critical Illness HMB, Lactose (placebo) - Critical Illness | Phase 2 | Unknown | Guy's and St Thomas' NHS Foundation Trust | 68 | 2018-06-18 | 2021-03-17 |
| Time-Restricted Feeding Plus Resistance Training in Active Females Beta-hydroxy beta-methylbutyrate, Resistance Training, Protein Supplementation - Healthy Active Females | Not applicable | Completed | Texas Tech University | 40 | 2018-01-17 | 2018-09-12 |
| Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit beta-hydroxy-beta-methylbutyrate, Placebo, Vital HP® - Muscle Atrophy | Phase 2 / Phase 3 | Withdrawn | Massachusetts General Hospital | 2017-01-01 | 2021-05-05 | |
| Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men. Beta-Hydroxy-Beta-Methylbutyrate, Placebo - Insulin Resistance, Age Problems | Not applicable | Completed | University of Nottingham | 20 | 2017-01-01 | 2019-03-12 |
| Effects of HMB Supplementation on Recovery Following ACL Surgery HMB, Placebo - ACL Injury | Not applicable | Completed | Metabolic Technologies Inc. | 4 | 2015-11-01 | 2019-03-13 |
| Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation After Liver Transplantation BETA-HYDROXY-BETA-METHYLBUTYRATE (HMB), Placebo - Sarcopenia | Not applicable | Completed | University of Roma La Sapienza | 22 | 2015-09-25 | 2019-03-11 |
| Pulmonary Rehabilitation Program (PRP) Versus PRP Plus Nutritional Supplementation in Patients With Bronchiectasis Pulmonary Rehabilitation, Hyperproteic oral nutritional supplement enriched with beta-hydroxy-beta-methylbutyrate - Bronchiectasis | Not applicable | Completed | Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud | 30 | 2013-09-01 | 2016-03-16 |
| Efficacy of Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation in Hemodialysis Patients HMB, placebo - Complication of Dialysis, Chronic Kidney Disease | Not applicable | Completed | University of Illinois at Urbana-Champaign | 41 | 2012-11-01 | 2016-10-31 |
| Nutritional Intervention for Age-related Muscular Function and Strength Losses Placebo, Vitamin D, Beta-hydroxy-Beta-methylbutyrate - Muscle Strength, Sarcopenia | Phase 1 | Completed | Metabolic Technologies Inc. | 76 | 2008-11-01 | 2014-09-17 |
Sarcopenia (6) · Muscular Atrophy (5) · Critical Illness (3) · Liver Cirrhosis (2) · Anterior Cruciate Ligament Injuries (1) · Asthenia (1) · Athletic Injuries (1) · Atrophy (1) · Bronchiectasis (1) · Diabetes Mellitus, Type 2 (1) · Fibrosis (1) · Frailty (1) · Huntington Disease (1) · Insulin Resistance (1) · Kidney Failure, Chronic (1)
Metabolic Technologies Inc. (2) · University of Roma La Sapienza (2) · Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud (1) · Guy's and St Thomas' NHS Foundation Trust (1) · Massachusetts General Hospital (1) · Mette M Berger (1) · Texas Tech University (1) · The Cleveland Clinic (1) · Tri-Service General Hospital (TSGH) (1) · Universidad Autónoma del Estado de Hidalgo (1) · Universidad Complutense de Madrid (1) · Universidad de Burgos (1) · University of Illinois at Urbana-Champaign (1) · University of Kansas Medical Center (1) · University of Nottingham (1)
United States (7) · Spain (3) · Italy (2) · United Kingdom (2) · Mexico (1) · Switzerland (1) · Taiwan (1)
Grant Tinsley, Ph.D. (1) · John A Rathmacher, PhD (1) · John A. Rathmacher, Ph.D. (1) · Juan Francisco Mielgo Ayuso, PhD (1) · Jui-Shan Lin, MD (1) · Kenneth Wilund, PhD (1) · Manuela Merli, Prof (1) · Nicholas Hart (1) · Robb Flynn, PhD (1) · Rodrigo Ronces Arrieta, BSc (1) · Sadeq A. Quraishi, MD,MHA,MMSc (1)
PMID 23514626, PMID 26522923, PMID 26797412, PMID 29406417, PMID 29656933, PMID 29952809, PMID 31268131, PMID 33512717, PMID 33946038, PMID 34358832, PMID 36657898, PMID 36717057, PMID 40784156, PMID 42202485
2016 (1)