8 completed, 8 recruiting, 6 not yet recruiting, 3 active not recruiting. 10 Not applicable, 6 Phase 4, 3 Phase 3, 1 Phase 2.
Follow Chronic Postsurgical Pain: new trials by email Literature Review of Chronic Postsurgical Pain trials Research Report on Chronic Postsurgical Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SPIP vs ESP Block in Cardiac Surgery Bilateral Superficial Parasternal Intercostal Plane Block, Bilateral Erector Spinae Plane Block, morphine PCA - Cardiac Surgery, Chronic Postsurgical Pain | Not applicable | Not yet recruiting | Ondokuz Mayıs University | 308 | 2026-12-01 | 2026-10-21 |
| Prevention of Postsurgical Chronic Pain in Children and Adolescents (PREVENDOL) Cognitive-behavioral therapy - Chronic Postsurgical Pain, Chronic Post-surgical Pain | Not applicable | Not yet recruiting | University Rovira i Virgili | 125 | 2026-11-01 | 2026-10-13 |
| Persistent Pain and Its Impact on Daily Life After Lung Surgery Longitudinal Assessment of Pain and Pain-Related Functional Interference - Chronic Postsurgical Pain, Acute Postoperative Pain | Not yet recruiting | Aerospace Center Hospital | 350 | 2026-10-10 | 2026-10-01 | |
| Erector Spinae Plane Block for Chronic Pain After Spinal Surgery NRS SCORE, Total tramadol consumption, Post Operative Pain Relievers - Postoperative Pain, Chronic Postsurgical Pain | Not applicable | Not yet recruiting | Aydin Adnan Menderes University | 80 | 2026-10-01 | 2026-09-22 |
| Postoperative Pain Trajectories After Endometriosis Surgery Perioperative quantitative sensory testing, questionnaire - Endometriosis, Postoperative Pain | Recruiting | Centre Hospitalier Universitaire, Amiens | 150 | 2026-07-07 | 2026-10-20 | |
| Perioperative Quantitative Sensory Testing and Incision Pain Mapping in Thoracic Surgery Perioperative QST and incision pain mapping assessment - Postoperative Pain, Chronic Postsurgical Pain | Not yet recruiting | Tongji Hospital | 46 | 2026-06-08 | 2026-06-17 | |
| Prevention of Chronic Postsurgical Pain in Chronic Opioid Users: standard institutional perioperative management, specialized teleconsultation - Chronic Postsurgical Pain, Chronic Opioid Users | Not applicable | Recruiting | Centre Hospitalier Universitaire, Amiens | 354 | 2026-01-14 | 2026-07-21 |
| Effect of Oliceridine Patient-Controlled Intravenous Analgesia on Postoperative Chronic Pain After Video-Assisted Thoracoscopic Lung Resection Oliceridine, Sufentanil - Chronic Postsurgical Pain | Phase 4 | Recruiting | Tianjin Medical University General Hospital | 320 | 2026-01-06 | 2026-09-01 |
| Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients Intertransverse process block, Sham block - Chronic Postsurgical Pain | Not applicable | Recruiting | Chinese University of Hong Kong | 96 | 2026-01-02 | 2026-03-18 |
| Effect of Erector Spinae Plane Block on Neuropathic Pain After Abdominal Hysterectomy Bupivacaine, Standard Perioperative Analgesia - Postoperative Pain, Chronic Postsurgical Pain | Not applicable | Completed | Necmettin Erbakan University | 200 | 2025-01-01 | 2026-09-23 |
| Effectiveness of Myofascial Release in Patients With Chronic Post Sternotomy Pain Syndrome Myofascial release, Breathing exercises, Pharmacological treatment - Chronic Postsurgical Pain | Not applicable | Not yet recruiting | Cairo University | 60 | 2024-12-15 | 2024-10-08 |
| Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty GlyNAC (combination of glycine and n-acetylcysteine), Placebo - Osteoarthritis, Knee, Total Knee Arthroplasty | Phase 4 | Recruiting | Vanderbilt University Medical Center | 148 | 2024-12-06 | 2025-12-11 |
| Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery questionnaire, phone call - Chronic Postsurgical Pain, Acute Pain | Not applicable | Recruiting | Centre Hospitalier Universitaire, Amiens | 693 | 2024-08-29 | 2026-01-16 |
| Intraoperative Sufentanil and Chronic Postsurgical Pain in Non-major Scheduled Abdominal Surgery phone interview - Chronic Postsurgical Pain, Chronic Pain | Phase 4 | Active not recruiting | Centre Hospitalier Universitaire, Amiens | 855 | 2024-06-24 | 2025-11-19 |
| Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes Esketamine - Scoliosis Correction, Postoperative Analgesia | Phase 4 | Recruiting | Peking University First Hospital | 312 | 2024-01-24 | 2025-07-30 |
| CSF Single-cell Sequencing and Proteomics of Chronic Postsurgical Pain in Patients With Lower Limb Fractures Chronic Postsurgical Pain | Unknown | Xuzhou Central Hospital | 20 | 2023-12-25 | 2023-11-13 | |
| Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery Esketamine - Scoliosis Correction, Esketamine | Phase 4 | Active not recruiting | Peking University First Hospital | 312 | 2023-10-24 | 2026-04-13 |
| Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes Esketamine, Dexmedetomidine, Sufentanil - Scoliosis Correction, Postoperative Analgesia | Phase 4 | Completed | Peking University First Hospital | 199 | 2023-01-30 | 2025-07-30 |
| Peripheral Blood Single Cell Sequencing Analysis of POD and CPSP in Elderly Patients After Total Knee Arthroplasty Postoperative Delirium, Chronic Postsurgical Pain | Unknown | Xuzhou Central Hospital | 10 | 2022-10-30 | 2023-03-08 | |
| Effect of TPVB on Postoperative Pain and Cognitive Function After VATS in Elderly Patients Measurement of cognitive function, Thoracic paravertebral block, The assessment of cognitive function - Postoperative Cognitive Dysfunction, Acute Postoperative Pain | Not applicable | Completed | The First Hospital of Qinhuangdao | 92 | 2022-05-12 | 2023-08-01 |
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Pain, Postoperative (28) · Acute Pain (2) · Chronic Pain (2) · Anxiety Disorders (1) · Breast Neoplasms (1) · Emergence Delirium (1) · Endometriosis (1) · Hyperalgesia (1) · Neuralgia (1) · Osteoarthritis, Knee (1) · Postoperative Cognitive Complications (1)
Neurologic Manifestations (28) · Pain (28) · Pathologic Processes (28) · Pathological Conditions, Signs and Symptoms (28) · Postoperative Complications (28) · Signs and Symptoms (28) · Mental Disorders (3) · Nervous System Diseases (3) · Neurocognitive Disorders (2) · Arthritis (1) · Breast Diseases (1) · Cognition Disorders (1) · Cognitive Dysfunction (1) · Confusion (1) · Delirium (1)
Esketamine (4) · Cognitive Behavioral Therapy (2) · Sufentanil (2) · Surveys and Questionnaires (2) · ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine (1) · Acetylcysteine (1) · Anesthesia, Epidural (1) · Anesthesia, General (1) · Breathing Exercises (1) · Bupivacaine (1) · Dexmedetomidine (1) · Digestive System Surgical Procedures (1) · Drug Therapy (1) · Educational Status (1) · Ketamine (1)
Centre Hospitalier Universitaire, Amiens (4) · Peking University First Hospital (3) · Xuzhou Central Hospital (2) · Aerospace Center Hospital (1) · Aydin Adnan Menderes University (1) · Beijing Tiantan Hospital (1) · Cairo University (1) · Chinese PLA General Hospital (1) · Chinese University of Hong Kong (1) · Mater Misericordiae University Hospital (1) · NYU Langone Health (1) · Necmettin Erbakan University (1) · Ondokuz Mayıs University (1) · Shanghai Zhongshan Hospital (1) · Tampere University Hospital (1)
China (10) · France (5) · Turkey (Türkiye) (3) · United States (2) · Denmark (1) · Egypt (1) · Finland (1) · Hong Kong (1) · Ireland (1) · Spain (1)
Dong-Xin Wang, MD,PhD (2) · Ahmad Mahdi Ahmad, PhD (1) · Daqing Ma, Doctor (1) · Donal Buggy, MB Bch BAO (1) · Dong-Xin Wang, MD, PhD (1) · Frederic T Billings, IV, MD (1) · Henry Wong (1) · Jing Wang, MD, PhD (1) · Junli Cao, Doctor (1) · Linyu Shi, master (1) · Lisa Doan, MD (1) · Liwei Wang, Doctor (1) · Lone Nikolajsen, DMSc (1)
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R01AG085287 (1), UH3CA261067 (1)