25 completed, 5 unknown, 2 recruiting, 1 terminated. 8 Not applicable, 8 Phase 2, 7 Phase 3, 6 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 8 |
| Phase 2 | 8 | Completed 5, Unknown 2, Recruiting 1 |
| Phase 3 | 7 | Completed 3, Unknown 3, Terminated 1 |
| Phase 1 | 6 | Completed 5, Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of a Cohort of Non-HIV Immunocompromised Patients With Toxoplasmosis at the Strasbourg University Hospital Cerebral Toxoplasmosis | Recruiting | University Hospital, Strasbourg, France | 30 | 2025-02-02 | 2025-12-23 | |
| Analysis of Cerebrospinal Fluid in Patients With Cerebral Toxoplasmosis at CHSD (2004-2024) Toxoplasmosis, Cerebral, Toxoplasmosis | Completed | Centre Hospitalier de Saint-Denis | 53 | 2024-07-01 | 2025-06-29 | |
| Pregnancy and Congenital Toxoplasmosis Estimation of the occurrence of retinochoroiditis in women with congenital toxoplasmosis and previous retinochoroiditis lesions (recurrence) during pregnancy and postpartum. - Congenital Toxoplasmosis, Retinochoroiditis | Completed | Hospices Civils de Lyon | 76 | 2023-05-10 | 2026-01-22 | |
| DON in Pediatric Cerebral Malaria 6-diazo-5-oxo-L-norleucine (DON), Placebo - Malaria, Cerebral | Phase 1 / Phase 2 | Recruiting | Douglas Postels, MD, MS | 152 | 2022-08-16 | 2026-10-23 |
| Automated Detection of Malarial Retinopathy in Patients Diagnosed With Cerebral Malaria Automated software for malarial retinopathy detection - Cerebral Malaria, Malarial Retinopathy | Completed | VisionQuest Biomedical LLC | 834 | 2022-03-15 | 2025-07-03 | |
| Diagnosis of Toxoplasma Gondii Infection by Exploration of Cellular Immunity (TOXCELL) anti-Toxoplasma gondii IgG and IgM dosage, cellular test - Toxoplasmosis, Toxoplasma Infections | Not applicable | Completed | Centre Hospitalier Universitaire de Nice | 66 | 2021-11-17 | 2024-10-15 |
| Dexamethasone for Cerebral Toxoplasmosis Dexamethasone, Placebo - Toxoplasmosis, Cerebral | Phase 2 | Unknown | Universitas Padjadjaran | 138 | 2021-04-16 | 2024-07-03 |
| New Diagnostic Approach for Congenital Toxoplasmosis blood additional samples - Congenital Toxoplasmosis | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 70 | 2018-06-20 | 2026-08-11 |
| Treating Brain Swelling in Pediatric Cerebral Malaria Mechanical ventilation, Hypertonic saline - Malaria, Cerebral | Phase 3 | Completed | Michigan State University | 57 | 2018-01-08 | 2025-03-17 |
| Driving Reduced AIDS-associated Meningo-encephalitis Mortality DREAMM - AIDS-Related Opportunistic Infections, Meningo-encephalitis | Not applicable | Completed | St George's, University of London | 495 | 2016-04-23 | 2022-05-04 |
| A Safety and Feasibility Study of Enteral LVT vs. Standard of Care for Seizure Control in Pediatric CM Oral Levetiracetam, Standard AED - Seizure, Epilepsy | Phase 2 | Completed | University of Rochester | 44 | 2014-01-01 | 2016-07-29 |
| Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria LEVETIRACETAM - Seizure, Epilepsy | Phase 1 / Phase 2 | Completed | University of Rochester | 7 | 2013-01-01 | 2016-09-15 |
| Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics) - Neurological Disorders, Cerebral Malaria | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 352 | 2012-09-01 | 2016-01-18 |
| Evaluation of the Efficacy and Safety of Inhaled Nitric Oxide as Adjunctive Treatment for Cerebral Malaria in Children inhaled nitric oxide, Placebo - Malaria, Cerebral | Phase 2 | Completed | Epicentre | 92 | 2011-09-01 | 2016-03-02 |
| Prevention of Congenital Toxoplasmosis With Pyrimethamine + Sulfadiazine Versus Spiramycine During Pregnancy Pyrimethamine/Sulfadiazine, Spiramycine - Congenital Toxoplasmosis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 149 | 2010-11-01 | 2016-09-29 |
| Assessment of Two Therapeutic Strategies in the Treatment of Children With Congenital Toxoplasmosis reducing treatment to 3 months, registered length of treatment - Congenital Toxoplasmosis | Phase 3 | Terminated | Centre Hospitalier Universitaire Dijon | 302 | 2010-07-28 | 2024-02-22 |
| Cerebral Toxoplasmosis and AIDS Toxoplasma PCR assay - Cerebral Toxoplasmosis, AIDS | Completed | University Hospital, Limoges | 46 | 2009-06-01 | 2019-07-05 | |
| Rehabilitation Program for Cognitive Deficits in Ugandan Children After Cerebral Malaria Cognitive rehabilitation training - Malaria, Cerebral | Not applicable | Completed | Makerere University | 123 | 2008-02-01 | 2012-12-06 |
| Hyperphenylalaninemia in Cerebral Malaria Plasmodium Falciparum Malaria | Completed | University of Utah | 285 | 2007-10-01 | 2012-10-22 | |
| Randomized Trial of Erythropoietin During Cerebral Malaria Placebo, Erythropoietin - Cerebral Malaria | Phase 2 / Phase 3 | Unknown | Claude Bernard University | 120 | 2007-10-01 | 2008-06-13 |
Showing 20 of 33. Sign in to see all of them.
Malaria, Cerebral (14) · Toxoplasmosis, Cerebral (13) · Toxoplasmosis (10) · HIV Infections (9) · Acquired Immunodeficiency Syndrome (8) · Encephalitis (7) · Malaria (7) · Toxoplasmosis, Congenital (6) · AIDS-Related Opportunistic Infections (5) · Epilepsy (2) · Malaria, Falciparum (2) · Meningitis, Bacterial (2) · Meningitis, Cryptococcal (2) · Seizures (2) · AIDS-Related Complex (1)
Central Nervous System Diseases (33) · Central Nervous System Parasitic Infections (33) · Infections (33) · Parasitic Diseases (33) · Protozoan Infections (33) · Central Nervous System Infections (32) · Nervous System Diseases (32) · Coccidiosis (19) · Brain Diseases (14) · Mosquito-Borne Diseases (14) · Vector Borne Diseases (14) · Abscess (13) · Brain Abscess (13) · Suppuration (13)
Pyrimethamine (8) · Leucovorin (5) · Atovaquone (2) · Clindamycin (2) · Levetiracetam (2) · Mannitol (2) · Sulfadiazine (2) · Air (1) · Azithromycin (1) · Clarithromycin (1) · Cognitive Training (1) · Dexamethasone (1) · Diazooxonorleucine (1) · Endothelium-Dependent Relaxing Factors (1) · Erythropoietin (1)
National Institute of Allergy and Infectious Diseases (NIAID) (5) · Makerere University (3) · Assistance Publique - Hôpitaux de Paris (2) · Hospices Civils de Lyon (2) · U.S. Army Medical Research and Development Command (2) · University of Rochester (2) · Centre Hospitalier Universitaire Dijon (1) · Centre Hospitalier Universitaire de Nice (1) · Centre Hospitalier de Saint-Denis (1) · Claude Bernard University (1) · Douglas Postels, MD, MS (1) · Epicentre (1) · Glaxo Wellcome (1) · Institute of Tropical Medicine, Belgium (1) · Michigan State University (1)
United States (10) · France (9) · Malawi (6) · Uganda (4) · Tanzania (2) · Cameroon (1) · Canada (1) · Democratic Republic of the Congo (1) · Indonesia (1) · Mali (1)
Luft B (3) · Gretchen L Birbeck, M.D. (2) · Peter J Weina, MD, PhD (2) · Angela Loyse, MD (1) · B Luft (1) · BJ Luft (1) · Besch CL (1) · Charles Ibingira, MMED (1) · Chirgwin K (1) · Donald L Granger, M.D. (1) · Douglas Postels, MD (1) · Emmanuel Bottieau, MD (1) · Esther D. Mwaikambo, M.D. (1)
PMID 31672143, PMID 17958887, PMID 19630971, PMID 19852829, PMID 27355620, PMID 34020114, PMID 37802567, PMID 38279124, PMID 41748157
R01NS074409 (2), 2009 (1), SB1AI162452 (1), U01AI126610 (1)