34 completed, 6 unknown, 2 recruiting, 2 terminated. 20 Phase 1, 10 Phase 2, 8 Not applicable, 8 Phase 3, 8 Phase 4.
Follow Pyrimethamine: new trials by email Literature Review of Pyrimethamine trials Research Report on Pyrimethamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combining Latency Reversing Agents to Address the HIV Reservoir Pyrimethamine (PYR), Lenalidomide, Topiramate (drug) - HIV (Human Immunodeficiency Virus), HIV -1 Infection | Phase 1 / Phase 2 | Not yet recruiting | Erasmus Medical Center | 30 | 2026-04-01 | 2026-02-03 |
| Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition MFGM-RUTF (milk fat globule membrane ready-to-use therapeutic food), S-RUTF (standard ready-to-use therapeutic food), Amoxicillin - Severe Acute Malnutrition, Cognitive Impairment | Not applicable | Recruiting | Washington University School of Medicine | 1600 | 2025-09-22 | 2026-10-23 |
| Bioequivalence Study of Sulfadoxine/Pyrimethamine 500/25 mg Dispersible Tablet Sulfadoxine 500 MG / Pyrimethamine 25 MG dispersible tablets., Sulfadoxine 500 MG / Pyrimethamine 25 MG dispersible tablets in SPAQ - Fasting | Phase 1 | Unknown | Swiss Pharma Nigeria Limited | 46 | 2024-07-01 | 2024-07-26 |
| Optimizing Reversal of HIV Latency With Combination Therapy Panobinostat 20 MG Oral Capsule, Pyrimethamine 200mg Oral Tablet, Lenalidomide 25 MG Oral Capsule - Hiv | Phase 1 / Phase 2 | Unknown | Erasmus Medical Center | 49 | 2024-04-01 | 2024-02-05 |
| Seasonal Malaria Chemoprevention Rapid Assessment Study Mozambique Sulfadoxine/pyrimethamine plus amodiaquine - Malaria,Falciparum, Chemoprevention | Phase 4 | Unknown | Malaria Consortium | 1000 | 2024-03-26 | 2024-03-29 |
| Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma Pyrimethamine - Head and Neck Cancer, Cancer of the Head and Neck | Early Phase 1 | Completed | Washington University School of Medicine | 22 | 2023-08-03 | 2025-08-17 |
| Bioequivalence Study of Sulfadoxine/ Pyrimethamine Dispersible Tablets in Healthy Subjects Under Fasting Conditions Sulfadoxine/Pyrimethamine dispersible tablets, 250 mg sulfadoxine / 12.5 mg pyrimethamine & 500 mg sulfadoxine / 25 mg pyrimethamine, G-COSPE® tablets - Bioequivalence | Phase 1 | Unknown | Emzor Pharmaceutical Industries Limited | 70 | 2022-12-01 | 2022-08-11 |
| An Investigational Study to Determine the Drug Level Profile of BMS-986165 in Healthy Male Volunteers Following Transporter Inhibition. BMS-986165, Pyrimethamine - Healthy Male Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 16 | 2019-09-12 | 2020-08-05 |
| Pyrimethamine for Intermediate/High-risk Myelodysplastic Syndromes (MDS) Pyrimethamine - Myelodysplastic Syndromes | Phase 1 | Withdrawn | Montefiore Medical Center | 2019-09-11 | 2021-09-22 | |
| Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa... Chloroquine Phosphate, PfSPZ Challenge, Pyrimethamine - Malaria | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 252 | 2019-05-23 | 2022-07-12 |
| LRAs United as a Novel Anti-HIV Strategy. Valproic Acid, Pyrimethamine - HIV-1-infection | Phase 1 / Phase 2 | Completed | Erasmus Medical Center | 28 | 2018-04-18 | 2021-04-29 |
| Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects Pyrimethamine, Calcium folinate - Toxoplasmosis | Phase 1 | Completed | GlaxoSmithKline | 14 | 2017-09-25 | 2020-03-27 |
| Dose Escalation PfSPZ-CVac Chloroquine Phosphate, Pyrimethamine, Sanaria PfSPZ Challenge - Malaria | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 55 | 2017-06-05 | 2021-06-01 |
| Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B... Chloroquine (CQ), Pyrimethamine (PYR), Sanaria PfSPZ Challenge (NF54) - Malaria | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 57 | 2015-07-21 | 2017-07-02 |
| Clinical Trial to Investigate the Pharmacokinetic/Pharmacodynamic Drug-Drug Interaction of Pyrimethamine and Metformin IR Metformin and Pyrimethamine - Healthy | Phase 1 | Completed | Seoul National University Hospital | 20 | 2013-06-01 | 2013-11-01 |
| Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria Efficacy of suphladoxine/pyrimethamine as IPTp - Pregnancy Complications Parasitic | Phase 4 | Unknown | Malaria Consortium, UK | 600 | 2011-01-01 | 2012-08-22 |
| Prevention of Congenital Toxoplasmosis With Pyrimethamine + Sulfadiazine Versus Spiramycine During Pregnancy Pyrimethamine/Sulfadiazine, Spiramycine - Congenital Toxoplasmosis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 149 | 2010-11-01 | 2016-09-29 |
| Pyrimethamine for the Treatment of Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma pyrimethamine - Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia | Phase 1 / Phase 2 | Completed | Dana-Farber Cancer Institute | 20 | 2010-03-01 | 2023-02-22 |
| SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS) Pyrimethamine - Familial Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Completed | Weill Medical College of Cornell University | 32 | 2009-11-01 | 2017-06-19 |
| A Randomised Trial of Artesunate-sulfamethoxypyrazine/Pyrimethamine Versus Praziquantel for the Treatment of S. Mansoni Artesunate+Sulfamethoxypyrazine/pyrimethamine, Praziquantel - Schistosoma Mansoni | Phase 3 | Completed | Kenya Medical Research Institute | 212 | 2009-10-01 | 2010-01-22 |
Showing 20 of 47. Sign in to see all of them.
Malaria (12) · Acquired Immunodeficiency Syndrome (10) · HIV Infections (9) · Toxoplasmosis (8) · Malaria, Falciparum (7) · Toxoplasmosis, Cerebral (7) · Encephalitis (6) · AIDS-Related Opportunistic Infections (4) · Anemia (3) · Autoimmune Diseases (2) · Autoimmune Lymphoproliferative Syndrome (2) · Gangliosidoses, GM2 (2) · Lymphadenopathy (2) · Lymphoproliferative Disorders (2) · Malaria, Vivax (2)
National Institute of Allergy and Infectious Diseases (NIAID) (12) · Erasmus Medical Center (3) · Centers for Disease Control and Prevention (2) · London School of Hygiene and Tropical Medicine (2) · Washington University School of Medicine (2) · Assistance Publique - Hôpitaux de Paris (1) · Bernhard Nocht Institute for Tropical Medicine (1) · Bristol-Myers Squibb (1) · Charite University, Berlin, Germany (1) · Dana-Farber Cancer Institute (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · Emzor Pharmaceutical Industries Limited (1) · Exsar Corporation (1) · GlaxoSmithKline (1) · Hospital Clinic of Barcelona (1)
United States (19) · Netherlands (3) · Canada (2) · Tanzania (2) · Afghanistan (1) · Australia (1) · France (1) · Germany (1) · Ghana (1) · Italy (1) · Jordan (1) · Kenya (1) · Malawi (1) · Mali (1) · Nigeria (1)
Luft B (3) · Casper Rokx, MD PhD (2) · Patrick E Duffy, M.D. (2) · Aditi Shastri, MD (1) · Alan Magill, MD (1) · B Luft (1) · BJ Luft (1) · Badria B El Sayed, PhD,MSc,BSc (1) · Besch CL (1) · Bijan Almassian, Ph.D. (1) · Chirgwin K (1) · Clara Menendez, MD, PhD (1) · Dale J. Lange, M.D. (1) · Daniel Chandramohan, PHD (1) · Dunja Hinze-Selch, MD (1)
PMID 34194041, PMID 39324693, PMID 15155976, PMID 15330070, PMID 16551365, PMID 16826475, PMID 16960779, PMID 17239256, PMID 17517949, PMID 17519410, PMID 18067679, PMID 18522503, PMID 18547415, PMID 18547416, PMID 18828899, PMID 19199542, PMID 19707564, PMID 20409302, PMID 20689585, PMID 20705516, PMID 21304921, PMID 22499837, PMID 26917051, PMID 33544819, PMID 34585740, PMID 9310602
2017 (1), 2019 (1)