11 completed, 1 recruiting, 1 unknown. 5 Not applicable, 3 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 5 |
| Phase 2 | 3 | Completed 2, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
Follow Toxoplasmosis, Cerebral: new trials by email Literature Review of Toxoplasmosis, Cerebral trials Research Report on Toxoplasmosis, Cerebral
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of a Cohort of Non-HIV Immunocompromised Patients With Toxoplasmosis at the Strasbourg University Hospital Cerebral Toxoplasmosis | Recruiting | University Hospital, Strasbourg, France | 30 | 2025-02-02 | 2025-12-23 | |
| Analysis of Cerebrospinal Fluid in Patients With Cerebral Toxoplasmosis at CHSD (2004-2024) Toxoplasmosis, Cerebral, Toxoplasmosis | Completed | Centre Hospitalier de Saint-Denis | 53 | 2024-07-01 | 2025-06-29 | |
| Dexamethasone for Cerebral Toxoplasmosis Dexamethasone, Placebo - Toxoplasmosis, Cerebral | Phase 2 | Unknown | Universitas Padjadjaran | 138 | 2021-04-16 | 2024-07-03 |
| Driving Reduced AIDS-associated Meningo-encephalitis Mortality DREAMM - AIDS-Related Opportunistic Infections, Meningo-encephalitis | Not applicable | Completed | St George's, University of London | 495 | 2016-04-23 | 2022-05-04 |
| Cerebral Toxoplasmosis and AIDS Toxoplasma PCR assay - Cerebral Toxoplasmosis, AIDS | Completed | University Hospital, Limoges | 46 | 2009-06-01 | 2019-07-05 | |
| Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Sulfadiazine, Clarithromycin, Atovaquone - Toxoplasmosis, Cerebral, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 100 | 2021-10-28 | |
| A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine Atovaquone - Toxoplasmosis, Cerebral, HIV Infections | Not applicable | Completed | Glaxo Wellcome | 2005-06-24 | ||
| A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients Pyrimethamine, Leucovorin calcium, Zidovudine - Toxoplasmosis, Cerebral, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 26 | 2021-11-04 | |
| A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS Pyrimethamine, Leucovorin calcium, Clindamycin - Toxoplasmosis, Cerebral, HIV Infections | Not applicable | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 30 | 2012-05-18 | |
| A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS Azithromycin, Pyrimethamine, Leucovorin calcium - Toxoplasmosis, Cerebral, HIV Infections | Phase 1 | Completed | Pfizer | 45 | 2008-08-26 | |
| Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients Pyrimethamine, Leucovorin calcium - Toxoplasmosis, Cerebral, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 150 | 2021-11-02 | |
| Toxoplasmic Encephalitis in Patients With AIDS. Treatment and Prevention of Relapse Pyrimethamine, Clindamycin - Toxoplasmosis, Cerebral, HIV Infections | Not applicable | Completed | Palo Alto Medical Foundation | 2005-06-24 | ||
| A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection Pyrimethamine - Toxoplasmosis, Cerebral, HIV Infections | Not applicable | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 600 | 2012-10-29 |
HIV Infections (9) · Acquired Immunodeficiency Syndrome (8) · Toxoplasmosis (8) · Encephalitis (7) · AIDS-Related Opportunistic Infections (5) · AIDS-Related Complex (1) · Brain Diseases (1) · Central Nervous System Infections (1) · Immunologic Deficiency Syndromes (1) · Meningitis (1) · Meningitis, Bacterial (1) · Meningitis, Cryptococcal (1) · Tuberculosis, Meningeal (1)
Abscess (13) · Brain Abscess (13) · Central Nervous System Diseases (13) · Central Nervous System Parasitic Infections (13) · Central Nervous System Protozoal Infections (13) · Coccidiosis (13) · Infections (13) · Nervous System Diseases (13) · Parasitic Diseases (13) · Protozoan Infections (13) · Suppuration (13) · Brain Diseases (12) · Central Nervous System Infections (12) · Immune System Diseases (12) · Blood-Borne Infections (11)
Pyrimethamine (7) · Leucovorin (5) · Atovaquone (2) · Clindamycin (2) · Azithromycin (1) · Clarithromycin (1) · Dexamethasone (1) · Sulfadiazine (1) · Zidovudine (1)
National Institute of Allergy and Infectious Diseases (NIAID) (5) · Centre Hospitalier de Saint-Denis (1) · Glaxo Wellcome (1) · Palo Alto Medical Foundation (1) · Pfizer (1) · St George's, University of London (1) · Universitas Padjadjaran (1) · University Hospital, Limoges (1) · University Hospital, Strasbourg, France (1)
United States (8) · France (3) · Cameroon (1) · Canada (1) · Indonesia (1) · Malawi (1) · Tanzania (1)
Luft B (3) · Angela Loyse, MD (1) · B Luft (1) · BJ Luft (1) · Besch CL (1) · Chirgwin K (1) · JL Vilde (1) · Jacobson M (1) · Remington J (1) · Remington JS (1) · Sofiati Dian, M.D., PhD (1)