5 completed, 2 unknown, 1 recruiting. 8 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 5, Unknown 2, Recruiting 1 |
| Phase 1 | 2 | Completed 1, Recruiting 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Central Nervous System Protozoal Infections: new trials by email Literature Review of Central Nervous System Protozoal Infections trials Research Report on Central Nervous System Protozoal Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DON in Pediatric Cerebral Malaria 6-diazo-5-oxo-L-norleucine (DON), Placebo - Malaria, Cerebral | Phase 1 / Phase 2 | Recruiting | Douglas Postels, MD, MS | 152 | 2022-08-16 | 2026-10-23 |
| Dexamethasone for Cerebral Toxoplasmosis Dexamethasone, Placebo - Toxoplasmosis, Cerebral | Phase 2 | Unknown | Universitas Padjadjaran | 138 | 2021-04-16 | 2024-07-03 |
| A Safety and Feasibility Study of Enteral LVT vs. Standard of Care for Seizure Control in Pediatric CM Oral Levetiracetam, Standard AED - Seizure, Epilepsy | Phase 2 | Completed | University of Rochester | 44 | 2014-01-01 | 2016-07-29 |
| Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria LEVETIRACETAM - Seizure, Epilepsy | Phase 1 / Phase 2 | Completed | University of Rochester | 7 | 2013-01-01 | 2016-09-15 |
| Evaluation of the Efficacy and Safety of Inhaled Nitric Oxide as Adjunctive Treatment for Cerebral Malaria in Children inhaled nitric oxide, Placebo - Malaria, Cerebral | Phase 2 | Completed | Epicentre | 92 | 2011-09-01 | 2016-03-02 |
| Randomized Trial of Erythropoietin During Cerebral Malaria Placebo, Erythropoietin - Cerebral Malaria | Phase 2 / Phase 3 | Unknown | Claude Bernard University | 120 | 2007-10-01 | 2008-06-13 |
| Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Sulfadiazine, Clarithromycin, Atovaquone - Toxoplasmosis, Cerebral, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 100 | 2021-10-28 | |
| Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients Pyrimethamine, Leucovorin calcium - Toxoplasmosis, Cerebral, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 150 | 2021-11-02 |
Malaria, Cerebral (5) · Malaria (3) · Toxoplasmosis, Cerebral (3) · Acquired Immunodeficiency Syndrome (2) · Epilepsy (2) · HIV Infections (2) · Seizures (2) · AIDS-Related Complex (1) · Brain Diseases (1) · Encephalitis (1) · Malaria, Falciparum (1) · Toxoplasmosis (1)
Central Nervous System Diseases (8) · Central Nervous System Infections (8) · Central Nervous System Parasitic Infections (8) · Infections (8) · Nervous System Diseases (8) · Parasitic Diseases (8) · Protozoan Infections (8) · Mosquito-Borne Diseases (5) · Vector Borne Diseases (5) · Brain Diseases (4) · Abscess (3) · Brain Abscess (3) · Coccidiosis (3) · Suppuration (3)
Leucovorin (2) · Levetiracetam (2) · Pyrimethamine (2) · Air (1) · Atovaquone (1) · Clarithromycin (1) · Dexamethasone (1) · Diazooxonorleucine (1) · Endothelium-Dependent Relaxing Factors (1) · Erythropoietin (1) · Nitric Oxide (1) · Nitrogen (1) · Sodium Chloride (1) · Sulfadiazine (1) · epoetin beta (1)
National Institute of Allergy and Infectious Diseases (NIAID) (2) · University of Rochester (2) · Claude Bernard University (1) · Douglas Postels, MD, MS (1) · Epicentre (1) · Universitas Padjadjaran (1)
Malawi (3) · United States (2) · Indonesia (1) · Mali (1) · Uganda (1)
Gretchen L Birbeck, M.D. (2) · BJ Luft (1) · Chirgwin K (1) · Douglas Postels, MD (1) · JL Vilde (1) · Juliet Mwanga-Amumpaire, Dr (1) · Luft B (1) · Sofiati Dian, M.D., PhD (1)
PMID 31672143, PMID 19630971, PMID 38279124, PMID 41748157
R01NS074409 (2)