5 completed, 1 recruiting. 6 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 5, Recruiting 1 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
Follow Central Nervous System Protozoal Infections: new trials by email Literature Review of Central Nervous System Protozoal Infections trials Research Report on Central Nervous System Protozoal Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DON in Pediatric Cerebral Malaria 6-diazo-5-oxo-L-norleucine (DON), Placebo - Malaria, Cerebral | Phase 1 / Phase 2 | Recruiting | Douglas Postels, MD, MS | 152 | 2022-08-16 | 2026-10-23 |
| Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria LEVETIRACETAM - Seizure, Epilepsy | Phase 1 / Phase 2 | Completed | University of Rochester | 7 | 2013-01-01 | 2016-09-15 |
| Study of the Safety of Intravenous Artesunate Intravenous Artesunate, Placebo - Malaria, Malaria, Cerebral | Phase 1 | Completed | U.S. Army Medical Research and Development Command | 26 | 2006-06-12 | 2018-10-25 |
| A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients Pyrimethamine, Leucovorin calcium, Zidovudine - Toxoplasmosis, Cerebral, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 26 | 2021-11-04 | |
| Study of the Safety of Intravenous Artesunate Intravenous artesunate - Malaria, Malaria, Cerebral | Phase 1 | Completed | U.S. Army Medical Research and Development Command | 40 | 2016-10-26 | |
| A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS Azithromycin, Pyrimethamine, Leucovorin calcium - Toxoplasmosis, Cerebral, HIV Infections | Phase 1 | Completed | Pfizer | 45 | 2008-08-26 |
Malaria, Cerebral (4) · Malaria (3) · Encephalitis (2) · HIV Infections (2) · Toxoplasmosis (2) · Toxoplasmosis, Cerebral (2) · Acquired Immunodeficiency Syndrome (1) · Epilepsy (1) · Malaria, Falciparum (1) · Seizures (1)
Central Nervous System Diseases (6) · Central Nervous System Infections (6) · Central Nervous System Parasitic Infections (6) · Infections (6) · Nervous System Diseases (6) · Parasitic Diseases (6) · Protozoan Infections (6) · Mosquito-Borne Diseases (4) · Vector Borne Diseases (4) · Brain Diseases (3) · Abscess (2) · Blood-Borne Infections (2) · Brain Abscess (2) · Coccidiosis (2)
Leucovorin (2) · Pyrimethamine (2) · Azithromycin (1) · Diazooxonorleucine (1) · Levetiracetam (1) · Mannitol (1) · Sodium Chloride (1) · Zidovudine (1)
U.S. Army Medical Research and Development Command (2) · Douglas Postels, MD, MS (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Pfizer (1) · University of Rochester (1)
United States (4) · Malawi (2)
Peter J Weina, MD, PhD (2) · B Luft (1) · Douglas Postels, MD (1) · Gretchen L Birbeck, M.D. (1) · Luft B (1) · Remington J (1)
PMID 31672143, PMID 38279124, PMID 41748157
R01NS074409 (1)