12 completed, 5 recruiting, 4 unknown, 1 not yet recruiting. 7 Not applicable, 3 Phase 2, 2 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 5, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 3 | Completed 2, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 1 | Recruiting 1 |
Follow Brain Abscess: new trials by email Literature Review of Brain Abscess trials Research Report on Brain Abscess
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Circulating Cell-Free DNA for Brain Abscess Diagnosis: A Pilot Study Plasma Microbial Cell-Free DNA Metagenomic Sequencing - Brain Abscess | Not applicable | Not yet recruiting | University Hospital, Grenoble | 15 | 2026-04-01 | 2026-03-18 |
| Study of a Cohort of Non-HIV Immunocompromised Patients With Toxoplasmosis at the Strasbourg University Hospital Cerebral Toxoplasmosis | Recruiting | University Hospital, Strasbourg, France | 30 | 2025-02-02 | 2025-12-23 | |
| Analysis of Cerebrospinal Fluid in Patients With Cerebral Toxoplasmosis at CHSD (2004-2024) Toxoplasmosis, Cerebral, Toxoplasmosis | Completed | Centre Hospitalier de Saint-Denis | 53 | 2024-07-01 | 2025-06-29 | |
| Brain Abscesses in Transplant Recipients: a Multicentre Retrospective Study (BAT-STUDY) Retrospective follow-up - Brain Abscess | Unknown | Assistance Publique - Hôpitaux de Paris | 200 | 2024-02-01 | 2024-02-05 | |
| Dexamethasone for Cerebral Toxoplasmosis Dexamethasone, Placebo - Toxoplasmosis, Cerebral | Phase 2 | Unknown | Universitas Padjadjaran | 138 | 2021-04-16 | 2024-07-03 |
| BIGlobal Intervention Study: Improving Diagnosis and Management of Suspected Brain Infections Globally Pragmatic, multi-component package - Meningitis, Encephalitis | Completed | University of Liverpool | 2233 | 2021-02-17 | 2025-03-03 | |
| Partial Oral Antibiotic Treatment for Bacterial Brain Abscess Early transition to oral antibiotics, Standard treatment of intravenous antibiotics - Brain Abscess, Cerebral Abscess | Phase 4 | Recruiting | Henrik Nielsen | 400 | 2020-11-06 | 2025-01-30 |
| The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT) Airway Management Pathway, Usual Care - Acute Brain Injury | Not applicable | Unknown | Sunnybrook Health Sciences Centre | 332 | 2020-04-01 | 2020-03-02 |
| Cognitive Function and Fatigue After Brain Abscess FDG-PET, EEG - Brain Abscess, Fatigue | Recruiting | University of Oslo | 50 | 2020-01-01 | 2025-07-04 | |
| MICROBIOLOGY OF CEREBRAL ABSCESSES Surgical puncture - Brain Abscess | Unknown | Assistance Publique Hopitaux De Marseille | 20 | 2019-10-01 | 2019-07-16 | |
| Fosfomycin I.v. for Treatment of Severely Infected Patients Bacterial Infections, Bone Diseases, Infectious | Recruiting | Infectopharm Arzneimittel GmbH | 1000 | 2016-12-01 | 2024-10-01 | |
| Driving Reduced AIDS-associated Meningo-encephalitis Mortality DREAMM - AIDS-Related Opportunistic Infections, Meningo-encephalitis | Not applicable | Completed | St George's, University of London | 495 | 2016-04-23 | 2022-05-04 |
| Central Nervous System Infections in Denmark Community-acquired CNS infections - Central Nervous System Infections, Bacterial Meningitis | Recruiting | Aalborg University Hospital | 1900 | 2015-01-01 | 2024-05-16 | |
| Cerebral Toxoplasmosis and AIDS Toxoplasma PCR assay - Cerebral Toxoplasmosis, AIDS | Completed | University Hospital, Limoges | 46 | 2009-06-01 | 2019-07-05 | |
| Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Sulfadiazine, Clarithromycin, Atovaquone - Toxoplasmosis, Cerebral, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 100 | 2021-10-28 | |
| A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine Atovaquone - Toxoplasmosis, Cerebral, HIV Infections | Not applicable | Completed | Glaxo Wellcome | 2005-06-24 | ||
| A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients Pyrimethamine, Leucovorin calcium, Zidovudine - Toxoplasmosis, Cerebral, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 26 | 2021-11-04 | |
| A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS Pyrimethamine, Leucovorin calcium, Clindamycin - Toxoplasmosis, Cerebral, HIV Infections | Not applicable | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 30 | 2012-05-18 | |
| A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS Azithromycin, Pyrimethamine, Leucovorin calcium - Toxoplasmosis, Cerebral, HIV Infections | Phase 1 | Completed | Pfizer | 45 | 2008-08-26 | |
| Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients Pyrimethamine, Leucovorin calcium - Toxoplasmosis, Cerebral, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 150 | 2021-11-02 |
Showing 20 of 22. Sign in to see all of them.
Toxoplasmosis, Cerebral (13) · Encephalitis (11) · HIV Infections (9) · Acquired Immunodeficiency Syndrome (8) · Toxoplasmosis (8) · AIDS-Related Opportunistic Infections (5) · Meningitis (4) · Meningitis, Bacterial (3) · Central Nervous System Infections (2) · AIDS-Related Complex (1) · Bacteremia (1) · Bacterial Infections (1) · Bone Diseases, Infectious (1) · Brain Diseases (1)
Abscess (22) · Central Nervous System Diseases (22) · Infections (22) · Nervous System Diseases (22) · Suppuration (22) · Brain Diseases (21) · Central Nervous System Infections (20) · Central Nervous System Parasitic Infections (13) · Central Nervous System Protozoal Infections (13) · Coccidiosis (13) · Neuroinflammatory Diseases (13) · Parasitic Diseases (13) · Protozoan Infections (13) · Immune System Diseases (12)
Pyrimethamine (7) · Leucovorin (5) · Atovaquone (2) · Clindamycin (2) · Azithromycin (1) · Clarithromycin (1) · Dexamethasone (1) · Sulfadiazine (1) · Zidovudine (1)
National Institute of Allergy and Infectious Diseases (NIAID) (5) · Aalborg University Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Assistance Publique Hopitaux De Marseille (1) · Centre Hospitalier de Saint-Denis (1) · Glaxo Wellcome (1) · Henrik Nielsen (1) · Infectopharm Arzneimittel GmbH (1) · Palo Alto Medical Foundation (1) · Pfizer (1) · St George's, University of London (1) · Sunnybrook Health Sciences Centre (1) · Universitas Padjadjaran (1) · University Hospital, Grenoble (1) · University Hospital, Limoges (1)
United States (8) · France (4) · Canada (2) · Denmark (2) · Malawi (2) · Austria (1) · Brazil (1) · Cameroon (1) · Germany (1) · Greece (1) · India (1) · Indonesia (1) · Italy (1) · Norway (1) · Tanzania (1)
Luft B (3) · Angela Loyse, MD (1) · B Luft (1) · BJ Luft (1) · Besch CL (1) · Chirgwin K (1) · Damon Scales, MD, PhD (1) · Daniel Dahlberg, MD, PhD (1) · Henrik Nielsen, Professor (1) · JL Vilde (1) · Jacob Bodilsen, MD (1) · Jacobson M (1) · Klaus-Friedrich Bodmann, Dr. (1)
PMID 27355620, PMID 34772441, PMID 37802567, PMID 39526777, PMID 39585965, PMID 40081400, PMID 40106180, PMID 42286374