10 completed, 3 unknown, 1 recruiting. 5 Phase 2, 5 Phase 3, 4 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Recruiting 1, Unknown 1 |
| Phase 3 | 5 | Unknown 3, Completed 2 |
| Phase 1 | 4 | Completed 3, Recruiting 1 |
| Not applicable | 1 | Completed 1 |
Follow Malaria, Cerebral: new trials by email Literature Review of Malaria, Cerebral trials Research Report on Malaria, Cerebral
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DON in Pediatric Cerebral Malaria 6-diazo-5-oxo-L-norleucine (DON), Placebo - Malaria, Cerebral | Phase 1 / Phase 2 | Recruiting | Douglas Postels, MD, MS | 152 | 2022-08-16 | 2026-10-23 |
| Automated Detection of Malarial Retinopathy in Patients Diagnosed With Cerebral Malaria Automated software for malarial retinopathy detection - Cerebral Malaria, Malarial Retinopathy | Completed | VisionQuest Biomedical LLC | 834 | 2022-03-15 | 2025-07-03 | |
| Treating Brain Swelling in Pediatric Cerebral Malaria Mechanical ventilation, Hypertonic saline - Malaria, Cerebral | Phase 3 | Completed | Michigan State University | 57 | 2018-01-08 | 2025-03-17 |
| A Safety and Feasibility Study of Enteral LVT vs. Standard of Care for Seizure Control in Pediatric CM Oral Levetiracetam, Standard AED - Seizure, Epilepsy | Phase 2 | Completed | University of Rochester | 44 | 2014-01-01 | 2016-07-29 |
| Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria LEVETIRACETAM - Seizure, Epilepsy | Phase 1 / Phase 2 | Completed | University of Rochester | 7 | 2013-01-01 | 2016-09-15 |
| Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics) - Neurological Disorders, Cerebral Malaria | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 352 | 2012-09-01 | 2016-01-18 |
| Evaluation of the Efficacy and Safety of Inhaled Nitric Oxide as Adjunctive Treatment for Cerebral Malaria in Children inhaled nitric oxide, Placebo - Malaria, Cerebral | Phase 2 | Completed | Epicentre | 92 | 2011-09-01 | 2016-03-02 |
| Rehabilitation Program for Cognitive Deficits in Ugandan Children After Cerebral Malaria Cognitive rehabilitation training - Malaria, Cerebral | Not applicable | Completed | Makerere University | 123 | 2008-02-01 | 2012-12-06 |
| Hyperphenylalaninemia in Cerebral Malaria Plasmodium Falciparum Malaria | Completed | University of Utah | 285 | 2007-10-01 | 2012-10-22 | |
| Randomized Trial of Erythropoietin During Cerebral Malaria Placebo, Erythropoietin - Cerebral Malaria | Phase 2 / Phase 3 | Unknown | Claude Bernard University | 120 | 2007-10-01 | 2008-06-13 |
| Study of the Safety of Intravenous Artesunate Intravenous Artesunate, Placebo - Malaria, Malaria, Cerebral | Phase 1 | Completed | U.S. Army Medical Research and Development Command | 26 | 2006-06-12 | 2018-10-25 |
| Mannitol as Adjunct Therapy for Childhood Cerebral Malaria Mannitol - Cerebral Malaria | Phase 3 | Unknown | Makerere University | 156 | 2004-10-01 | 2005-06-24 |
| Efficacy of Intrarectal Versus Intravenous Quinine for the Treatment of Childhood Cerebral Malaria Intrarectal quinine - Cerebral Malaria | Phase 3 | Unknown | Makerere University | 108 | 2003-09-01 | 2005-08-04 |
| Study of the Safety of Intravenous Artesunate Intravenous artesunate - Malaria, Malaria, Cerebral | Phase 1 | Completed | U.S. Army Medical Research and Development Command | 40 | 2016-10-26 |
Malaria (7) · Epilepsy (2) · Malaria, Falciparum (2) · Seizures (2) · Coma (1) · Meningitis, Bacterial (1) · Meningitis, Cryptococcal (1) · Neglected Diseases (1) · Nervous System Diseases (1) · Neurosyphilis (1) · Tuberculosis, Central Nervous System (1)
Central Nervous System Diseases (14) · Central Nervous System Infections (14) · Central Nervous System Parasitic Infections (14) · Central Nervous System Protozoal Infections (14) · Infections (14) · Mosquito-Borne Diseases (14) · Parasitic Diseases (14) · Protozoan Infections (14) · Vector Borne Diseases (14) · Nervous System Diseases (13) · Malaria (7) · Pathological Conditions, Signs and Symptoms (4) · Neurologic Manifestations (3) · Signs and Symptoms (3) · Brain Diseases (2)
Levetiracetam (2) · Mannitol (2) · Air (1) · Cognitive Training (1) · Diazooxonorleucine (1) · Endothelium-Dependent Relaxing Factors (1) · Erythropoietin (1) · Nitric Oxide (1) · Nitrogen (1) · Respiration, Artificial (1) · Saline Solution, Hypertonic (1) · Sodium Chloride (1) · epoetin beta (1)
Makerere University (3) · U.S. Army Medical Research and Development Command (2) · University of Rochester (2) · Claude Bernard University (1) · Douglas Postels, MD, MS (1) · Epicentre (1) · Institute of Tropical Medicine, Belgium (1) · Michigan State University (1) · University of Utah (1) · VisionQuest Biomedical LLC (1)
Malawi (5) · Uganda (4) · United States (2) · Democratic Republic of the Congo (1) · Mali (1) · Tanzania (1)
Gretchen L Birbeck, M.D. (2) · Peter J Weina, MD, PhD (2) · Charles Ibingira, MMED (1) · Donald L Granger, M.D. (1) · Douglas Postels, MD (1) · Emmanuel Bottieau, MD (1) · Esther D. Mwaikambo, M.D. (1) · Jane Achan, MBChB (1) · Juliet Mwanga-Amumpaire, Dr (1) · Marleen Boelaert, MD, PhD (1) · Terrie E Taylor, DO (1)
PMID 31672143, PMID 17958887, PMID 19630971, PMID 19852829, PMID 34020114, PMID 38279124, PMID 41748157
R01NS074409 (2), SB1AI162452 (1), U01AI126610 (1)