12 withdrawn. 12 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Withdrawn 12 |
| Phase 1 | 1 | Withdrawn 1 |
| Phase 3 | 1 | Withdrawn 1 |
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study on Trametinib for Surgical Unruptured AVMs Trametinib tablet - Arteriovenous Malformations | Phase 2 | Withdrawn | University Health Network, Toronto | 2024-01-30 | 2026-05-22 | |
| Addition of Acetaminophen in Standard PDA Management Intravenous Ibuprofen, Intravenous Ibuprofen + Oral Acetaminophen - Patent Ductus Arteriosus | Phase 2 | Withdrawn | University of Florida | 2021-04-01 | 2021-06-24 | |
| Nitric Oxide During Cardiopulmonary Bypass in Neonates to Reduce Risk of Acute Kidney Injury gases Nitric Oxide (gNO) - Acute Kidney Injury, Congenital Heart Disease | Phase 2 / Phase 3 | Withdrawn | Children's Hospital Medical Center, Cincinnati | 2019-10-20 | 2020-02-06 | |
| Aesculus Hippocastanum L. on Fontan Circulation Aesculus Hippocastanum / Horse Chestnut, Placebo - Univentricular Heart | Phase 2 | Withdrawn | Casa Espirita Terra de Ismael | 2017-10-31 | 2021-01-28 | |
| Retreatment and Its Efficiency of Thalidomide for Vascular Malformation Patients With Failure of First Course Treatment Thalidomide, Placebo - Gastrointestinal Bleeding of Unknown Origin, Gastrointestinal Vascular Malformation | Phase 2 | Withdrawn | Zhizheng Ge | 2015-12-01 | 2016-04-21 | |
| Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli Apixaban, Placebo - Patent Foramen Ovale, Cardiac Implantable Electronic Device | Phase 2 | Withdrawn | Mayo Clinic | 2015-05-01 | 2018-11-16 | |
| Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MEK162 in Noonan Syndrome Hypertrophic Cardiomyopathy MEK162 - Cardiomegaly | Phase 2 | Withdrawn | Array Biopharma, now a wholly owned subsidiary of Pfizer | 2012-02-01 | 2020-10-06 | |
| Timolol Option for Ulcerated Hemangiomas (TOUCH Trial) Timolol 0.5% Gel Forming Solution (GFS), Mupirocin 2% Ointment - Infantile Hemangiomas | Phase 2 | Withdrawn | Children's Hospital of Philadelphia | 2011-02-01 | 2014-01-17 | |
| Second Course of Therapy for Resistant Patent Ductus Arteriosus (PDA) Indomethacin, Ibuprofen - Patent Ductus Arteriosus | Phase 2 | Withdrawn | Shaare Zedek Medical Center | 2010-06-01 | 2012-06-07 | |
| Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding Thalidomide, Placebo - Gastrointestinal Hemorrhage, Vascular Malformation | Phase 2 | Withdrawn | Shanghai Jiao Tong University School of Medicine | 2010-03-01 | 2016-04-28 | |
| Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients Iloprost, Placebo - Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure | Phase 1 / Phase 2 | Withdrawn | Seattle Children's Hospital | 2009-09-01 | 2015-01-19 | |
| Parenteral Phenoxybenzamine During Congenital Heart Disease Surgery Phenoxybenzamine, Standard surgical approach - Congenital Heart Disease | Phase 2 | Withdrawn | Vanderbilt University | 2008-10-01 | 2017-05-01 |
Heart Defects, Congenital (3) · Vascular Malformations (3) · Ductus Arteriosus, Patent (2) · Gastrointestinal Hemorrhage (2) · Acute Kidney Injury (1) · Angiodysplasia (1) · Arteriovenous Malformations (1) · Cardiomegaly (1) · Cardiomyopathy, Hypertrophic (1) · Cognitive Dysfunction (1) · Embolism, Paradoxical (1) · Foramen Ovale, Patent (1) · Hemangioma (1) · Hemangioma, Capillary (1) · Hypertension, Pulmonary (1)
Cardiovascular Diseases (12) · Congenital Abnormalities (12) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (12) · Heart Diseases (8) · Heart Defects, Congenital (5) · Vascular Diseases (4) · Pathological Conditions, Signs and Symptoms (3) · Digestive System Diseases (2) · Gastrointestinal Diseases (2) · Hemorrhage (2) · Pathologic Processes (2) · Aortic Stenosis, Subvalvular (1) · Aortic Valve Disease (1) · Aortic Valve Stenosis (1)
Thalidomide (2) · Acetaminophen (1) · Ibuprofen (1) · Iloprost (1) · Indomethacin (1) · Mupirocin (1) · Ointments (1) · Phenoxybenzamine (1) · Timolol (1) · apixaban (1) · binimetinib (1) · horse chestnut seed (1) · trametinib (1)
Array Biopharma, now a wholly owned subsidiary of Pfizer (1) · Casa Espirita Terra de Ismael (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Philadelphia (1) · Mayo Clinic (1) · Seattle Children's Hospital (1) · Shaare Zedek Medical Center (1) · Shanghai Jiao Tong University School of Medicine (1) · University Health Network, Toronto (1) · University of Florida (1) · Vanderbilt University (1) · Zhizheng Ge (1)
United States (4) · China (2) · Brazil (1) · Canada (1) · Israel (1) · United Kingdom (1)
Albert C. Yan, MD (1) · Cathy Hammerman, MD (1) · Christopher DeSimone, MD (1) · David P Bichell, MD (1) · Delphine Yung, MD (1) · Ivan Radovanovic, MD PhD (1) · Patrick McMahon, MD (1) · Paul Friedman, MD (1) · Samuel Asirvatham, MD (1) · Sanket D Shah, MD (1) · Vikash S. Oza, MD (1) · Zhizheng Ge, MD. Ph.D (1) · Zhizheng Ge, Ph.D, MD. (1)