3 completed, 3 unknown, 1 enrolling by invitation, 1 recruiting. 4 Not applicable, 2 Phase 2, 2 Phase 4, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Unknown 3, Recruiting 1 |
| Phase 2 | 2 | Completed 1, Withdrawn 1 |
| Phase 4 | 2 | Completed 2 |
| Early Phase 1 | 1 | Enrolling by invitation 1 |
Follow horse chestnut seed: new trials by email Literature Review of horse chestnut seed trials Research Report on horse chestnut seed
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Efficacy and Safety of Venostan in Promoting Postoperative Swelling Reduction in Patients With Ankle Fractures Venostasin (horse chestnut seed extract tablets), standard treatment - Swelling/ Edema | Not applicable | Recruiting | Beijing Jishuitan Hospital | 290 | 2025-04-16 | 2025-07-16 |
| The Efficacy of Aescin in Combination With Micronized Purified Flavonoid Fraction (MPFF) in the Control of Bleeding and Prevent Recurrence of Acute Internal Hemorrhoids, A Randomized Controlled Trial, A Pilot Study Aescin in Horse Chestnut, MPFF - Hemorrhoid | Early Phase 1 | Enrolling by invitation | Chiang Mai University | 120 | 2024-12-20 | 2024-12-24 |
| Clinical Trial of Aesculus Hippocastanum and Associations Versus Diosmina and Hesperidina in Chronic Venous Insuficiency Aesculus hippocastanum, and associations - Chronic Venous Insufficiency | Phase 4 | Completed | Fundação Educacional Serra dos Órgãos | 120 | 2024-11-06 | 2026-01-07 |
| Randomized Study of Oral Aesculus Hippocastanum and Combinations in Hemorrhoidal Disease After 60 Days of Treatment Aesculus hippocastanum, and interventions - Haemorrhoidal Disease | Phase 4 | Completed | Fundação Educacional Serra dos Órgãos | 120 | 2024-09-01 | 2026-01-07 |
| The Efficacy of Aescin in Combination With MPFF in the Early Control of Bleeding From Acute Internal Hemorrhoids, A Randomized Controlled Trial Aescin in Horse Chestnut, Flavonoid - Anorectal Disorder | Not applicable | Unknown | Chiang Mai University | 60 | 2024-04-01 | 2024-04-12 |
| Chestnut Consumption on Modulation of Gut Microbiota and Metabolic Parameters Chestnut - Diet Habit | Not applicable | Unknown | Universidade Nova de Lisboa | 33 | 2022-11-15 | 2023-01-31 |
| Aesculus Hippocastanum L. on Fontan Circulation Aesculus Hippocastanum / Horse Chestnut, Placebo - Univentricular Heart | Phase 2 | Withdrawn | Casa Espirita Terra de Ismael | 2017-10-31 | 2021-01-28 | |
| Study of the Nutraceutical Properties and Health Benefits of Traditional Components of the Mediterranean Diet Hazelnuts, Chocolate, Red wine - Obesity | Not applicable | Unknown | University of Rome Tor Vergata | 50 | 2013-05-01 | 2015-12-10 |
| Horse Chestnut Seed Extract for Lymphedema Horse Chestnut Seed Extract - Lymphedema of Arm | Phase 2 | Completed | University of Wisconsin, Madison | 56 | 2002-05-01 | 2015-06-02 |
Hemorrhoids (2) · Ankle Fractures (1) · Edema (1) · Feeding Behavior (1) · Hemorrhage (1) · Inflammation (1) · Obesity (1) · Rectal Diseases (1) · Univentricular Heart (1)
Chiang Mai University (2) · Fundação Educacional Serra dos Órgãos (2) · Beijing Jishuitan Hospital (1) · Casa Espirita Terra de Ismael (1) · Universidade Nova de Lisboa (1) · University of Rome Tor Vergata (1) · University of Wisconsin, Madison (1)
Brazil (3) · Thailand (2) · China (1) · Italy (1) · Portugal (1) · United States (1)
Carlos Nunes, Professor (2) · Ana Faria, PhD (1) · Paul R Hutson, PharmD (1)
PMID 15364642, PMID 22895941, PMID 24876915, PMID 25022355, PMID 25432492, PMID 26347355, PMID 27709360, PMID 28429343, PMID 28537652, PMID 28601084, PMID 28855976, PMID 29147070, PMID 30419927, PMID 30451751, PMID 31593559, PMID 36203988, PMID 36672947, PMID 39339676, PMID 41470854, PMID 42392851