40 completed, 11 recruiting, 7 terminated, 7 unknown. 21 Not applicable, 8 Phase 2, 7 Phase 4, 4 Phase 1, 3 Phase 3.
Follow Cardiac Failure: new trials by email Literature Review of Cardiac Failure trials Research Report on Cardiac Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels Cardiac Failure, Graft Rejection | Recruiting | Northwestern University | 250 | 2025-10-28 | 2026-08-11 | |
| Social Prescribing to Improve Adherence and Outcomes in Women With Heart Failure Social prescribing - Heart Failure, Cardiac Failure | Not applicable | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 200 | 2025-10-23 | 2026-02-20 |
| Cardiac Remodelling Following Endovascular Repair of the Aorta cardiac magnetic ressonance - Cardiac Failure, Aortic Disease | Recruiting | Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa | 40 | 2025-09-01 | 2026-02-17 | |
| Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage Xenon, air/oxygen - Subarachnoid Hemorrhage, Aneurysmal, Cerebral Injury | Phase 2 | Recruiting | Turku University Hospital | 160 | 2025-04-22 | 2025-05-01 |
| Study of Platelet Population Changes Under Circulatory Support With ECMO Cardiac Failure, Respiratory Failure | Recruiting | University Hospital, Strasbourg, France | 75 | 2025-03-11 | 2026-01-12 | |
| Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs Cardiac Failure, Graft Rejection | Recruiting | Northwestern University | 150 | 2025-02-06 | 2026-08-25 | |
| Landiolol in Mitral Valve Surgery Landiolol, Placebo - Cardiac Failure, Low Cardiac Output Syndrome | Phase 4 | Recruiting | Università Vita-Salute San Raffaele | 1500 | 2025-01-28 | 2025-12-29 |
| Non-invasive Monitoring of Mixed Venous Oxygen Saturation Using the Capnodynamic Method in Adults Ventilatory Failure, Cardiac Failure | Not yet recruiting | Fundación de Investigación Biomédica - Hospital Universitario de La Princesa | 25 | 2024-12-01 | 2024-10-10 | |
| The Effect of phoSPHocreatine on mEdical Emergency Team (Met) tREated Patients Phosphocreatine, Placebo - Hypotension, Consciousness, Level Altered | Phase 3 | Recruiting | Università Vita-Salute San Raffaele | 400 | 2024-10-08 | 2025-08-06 |
| A Post Market Surveillance Study of the Hemovent Extracorporeal Cardiopulmonary Support System:The MOBYBOX Trial MOBYBOX System - Cardiac Failure, Respiratory Failure | Recruiting | Hemovent GmbH | 60 | 2024-04-30 | 2025-05-31 | |
| A Preliminary Study for INFORMED Beta blocker - Heart Failure, Heart Failure, Diastolic | Phase 4 | Recruiting | Weill Medical College of Cornell University | 18 | 2024-02-07 | 2026-08-21 |
| Efficacy of AI EF Screening by Using Smartphone Application Recorded PLAX View Cardiac Ultrasound Video Clips Easy EF - Heart Failure, Heart Failure With Reduced Ejection Fraction | Not applicable | Completed | Rayong Hospital | 923 | 2023-05-01 | 2024-03-26 |
| Physical Exercise and Telephone Follow-up Mediated by Telerehabilitation conventional rehabilitation, Education, telerehabilitation - Cardiac Failure | Not applicable | Active not recruiting | Clínica de Occidente S.A | 156 | 2022-10-15 | 2024-10-28 |
| Blender Biomarkers: A BLENDER Sub-study to Evaluate the Effect of Oxygen Dose on Oxidative Stress and Organ Injury Cardiac Failure, Critical Illness | Unknown | Australian and New Zealand Intensive Care Research Centre | 30 | 2022-04-18 | 2023-10-26 | |
| Impact of Beta-blockers on Physical Function in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2023-09-08 |
| Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2024-04-09 |
| Treatment of Pulmonary Hypertension in High-risk Cardiac Surgery Patients Using Inhalational and Intravenous Agents levosimendan at a dose of 6 mcg/kg, milrinone at a dose of 50 mcg/kg - Hypertension, Pulmonary, Cardiac Failure | Not applicable | Completed | Aretaieion University Hospital | 40 | 2021-01-27 | 2025-07-22 |
| Levosimendan Administration in Pulmonary Hypertension levosimendan at a dose of 3 mcg/kg, levosimendan at a dose of 6 mcg/kg, levosimendan at a dose of 12 mcg/kg - Hypertension, Pulmonary, Cardiac Failure | Not applicable | Completed | Aretaieion University Hospital | 45 | 2020-10-17 | 2023-02-08 |
| Absent Visitors: The Wider Implications of COVID-19 on Non-COVID Cardiothoracic ICU Patients, Relatives and Staff COVID visitation restrictions - Cardiovascular Diseases, Delirium | Unknown | University of Glasgow | 1000 | 2020-09-01 | 2020-09-04 | |
| Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS). Pemziviptadil (PB1046), Low Dose (10 mg) Control - Acute Respiratory Distress Syndrome, Coronavirus | Phase 2 | Terminated | PhaseBio Pharmaceuticals Inc. | 54 | 2020-07-15 | 2020-12-11 |
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Heart Failure (69) · Respiratory Insufficiency (8) · Heart Diseases (6) · Critical Illness (4) · Hypertension, Pulmonary (4) · Respiratory Distress Syndrome (4) · COVID-19 (3) · Cardiovascular Diseases (3) · Heart Failure, Diastolic (3) · Renal Insufficiency (3) · Anxiety Disorders (2) · Atrial Fibrillation (2) · Cardiotoxicity (2) · Depression (2) · Hyperoxia (2)
Cardiovascular Diseases (66) · Heart Diseases (63) · Pathological Conditions, Signs and Symptoms (24) · Pathologic Processes (17) · Respiratory Tract Diseases (15) · Signs and Symptoms (12) · Vascular Diseases (12) · Respiration Disorders (10) · Lung Diseases (8) · Nervous System Diseases (7) · Behavior (5) · Neurologic Manifestations (5) · Signs and Symptoms, Respiratory (5) · Disease Attributes (4) · Hypertension (4)
Adrenergic beta-Antagonists (3) · Acebutolol (2) · Atenolol (2) · Betaxolol (2) · Bisoprolol (2) · Carvedilol (2) · Furosemide (2) · Labetalol (2) · Metoprolol (2) · Nadolol (2) · Nebivolol (2) · Penbutolol (2) · Pindolol (2) · Propranolol (2) · Sotalol (2)
Bristol-Myers Squibb (5) · Aretaieion University Hospital (3) · Weill Medical College of Cornell University (3) · Australian and New Zealand Intensive Care Research Centre (2) · Northwestern University (2) · Università Vita-Salute San Raffaele (2) · Aston University (1) · Barts & The London NHS Trust (1) · Baxter Healthcare Corporation (1) · CENTOGENE GmbH Rostock (1) · Cardiff and Vale University Health Board (1) · Catharina Ziekenhuis Eindhoven (1) · Centre Chirurgical Marie Lannelongue (1) · Centre Hospitalier Universitaire de Besancon (1) · Chinese Academy of Medical Sciences, Fuwai Hospital (1)
United States (21) · United Kingdom (8) · France (6) · Greece (3) · Poland (3) · Switzerland (3) · Australia (2) · Brazil (2) · China (2) · Hungary (2) · Italy (2) · Netherlands (2) · Sweden (2) · Austria (1) · Canada (1)
Kassiani Theodoraki, PhD, DESA (3) · Parag Goyal, MD (2) · Alister Hart, MD,FRCSG (1) · Andrew R Yates, MD (1) · Ashley Thomas, MSc (1) · Ben Shelley (1) · Brian M Everist, MD (1) · Carisi A Polanczyk, MD ScD (1) · Carlo di Mario (1) · Charles Emery, Ph.D. (1) · Christopher A Miller, MBChB, PhD (1) · David Morales, MD (1)
PMID 31168885, PMID 10761937, PMID 11263649, PMID 11913479, PMID 12948221, PMID 13211322, PMID 14349898, PMID 15473335, PMID 15477280, PMID 16131888, PMID 16568436, PMID 17068719, PMID 18757952, PMID 18827237, PMID 18835128, PMID 19257889, PMID 19304018, PMID 19483225, PMID 19670411, PMID 19794161, PMID 19937124, PMID 20544916, PMID 21037026, PMID 21349784, PMID 21656317, PMID 21692725, PMID 21969427, PMID 22252702, PMID 22308623, PMID 22336970, PMID 22348447, PMID 22351785, PMID 22374741, PMID 22419548, PMID 22447496, PMID 22455358, PMID 22520206, PMID 22723536, PMID 22798311, PMID 23090916, PMID 23138590, PMID 23307670, PMID 23313008, PMID 23333530, PMID 23421810, PMID 23762480, PMID 23813157, PMID 23850250, PMID 23948123, PMID 24103764
2016 (2), K76AG064428 (2), 2017 (1), 2018 (1), 2019 (1), 2023 (1), 2025 (1), R01HL113387 (1), R01HL173248 (1), R01NR016191 (1)