8 recruiting, 5 completed, 5 not yet recruiting, 1 unknown. 20 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 20 | Recruiting 8, Completed 5, Not yet recruiting 5, Unknown 1, Withdrawn 1 |
| Phase 2 | 4 | Recruiting 2, Completed 1, Not yet recruiting 1 |
Follow Cannabis Use: new trials by email Literature Review of Cannabis Use trials Research Report on Cannabis Use
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Behavioral Pharmacology of THC and Beta-Myrcene Placebo, THC, Beta-Myrcene - Cannabis Use | Phase 1 | Not yet recruiting | Johns Hopkins University | 32 | 2027-07-01 | 2026-07-31 |
| Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance Cannabis - Cannabis Use, Impaired Driving | Phase 1 | Not yet recruiting | Johns Hopkins University | 40 | 2026-12-01 | 2026-10-16 |
| Cannabis and Opioid Use Disorder, Study 2 Inhaled Cannabis, Intranasal Opioid - Opioid Use Disorders, Cannabis Use | Phase 1 | Not yet recruiting | University of Kentucky | 100 | 2026-11-30 | 2026-10-09 |
| Cannabis Effects on Opioid Self-Administration Cannabis, Placebo Cannabis, Intranasal Opioid Agonist - Opioid Use Disorder, Cannabis Use | Phase 1 | Not yet recruiting | Shanna Babalonis, PhD | 30 | 2026-11-30 | 2026-10-14 |
| Acute Effects of Cannabis on Cognition and Affect THC 20mg, Placebo - Cannabis Use | Phase 1 | Recruiting | Washington State University | 92 | 2026-09-11 | 2026-10-29 |
| Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery Cannabidiol (CBD) only, Placebo only, Delta-9-tetrahydrocannabinol (THC) only - PTSD, Post Traumatic Stress Disorder | Phase 1 / Phase 2 | Not yet recruiting | Leslie Lundahl | 280 | 2026-09-01 | 2026-08-26 |
| Warrior CARE: Cannabis Behavioral Health Tetrahydrocannabinol, Cannabidiol, Placebo - Post Traumatic Stress Disorder, Cannabis Use | Phase 1 / Phase 2 | Recruiting | Wayne State University | 500 | 2025-09-22 | 2026-08-07 |
| Effect of Cannabis on E-Cigarette Use Behavior THC High Dose, THC Low Dose, THC 0mg - Cannabis Use, Tobacco Use | Phase 1 | Recruiting | Johns Hopkins University | 100 | 2025-03-19 | 2026-04-09 |
| Effect of Cannabis on Cigarette Use Behavior THC 30mg, THC 5mg, THC 0mg - Cannabis Use, Tobacco Use | Phase 1 | Recruiting | Johns Hopkins University | 100 | 2025-01-22 | 2026-01-16 |
| HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention) Information Motivation Behavioral and Motivational Interviewing (IMB-MI) technique - Hiv, Alcohol Drinking | Phase 1 | Recruiting | Yale University | 100 | 2025-01-15 | 2026-09-25 |
| Maternal Choline Supplementation and Cannabis Use During Pregnancy: Impact on Early Brain Development Placebo, Choline - Child Development, Cannabis Use | Phase 1 | Recruiting | University of Colorado, Denver | 140 | 2024-11-25 | 2025-02-03 |
| The Impact of Product Formulation on the Pharmacokinetics and Pharmacodynamics of Cannabis Edibles Cannabis, Placebo - Cannabis Use | Phase 1 | Recruiting | Johns Hopkins University | 80 | 2024-07-10 | 2026-04-13 |
| SV2A in Older Adults [11C]UCB-J PET - Cannabis Use | Phase 1 / Phase 2 | Recruiting | Yale University | 24 | 2022-07-06 | 2026-10-20 |
| Marijuana Effects on Simulated Driving Performance Marijuana, Alcohol, placebo alcohol - Cannabis, Cannabis Use | Phase 1 | Completed | Shanna Babalonis, PhD | 10 | 2019-07-01 | 2024-07-31 |
| Pharmacokinetics and Pharmacological Effects of a Standardized Cannabis Preparation Cannabis decoction, Cannabis oil, Vaporized cannabis - Cannabis Use, Healthy Subjects | Phase 1 | Completed | Germans Trias i Pujol Hospital | 43 | 2018-12-10 | 2021-04-12 |
| Neural Correlates of Driving and Cannabis Cannabis - Cannabis Use, Driving Impaired | Phase 1 | Unknown | Unity Health Toronto | 12 | 2018-08-08 | 2020-03-23 |
| Effect of Lorcaserin on Cannabis Withdrawal and Self-administration Lorcaserin, Placebo, Marijuana - Cannabis Use | Phase 1 / Phase 2 | Completed | New York State Psychiatric Institute | 15 | 2017-09-05 | 2022-07-26 |
| Effects of Cannabis Administration Routes on Human Performance and Pharmacokinetics Placebo + Placebo, Oral Cannabis + Placebo, Placebo + Inhaled Cannabis - Cannabis Use | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 28 | 2014-06-14 | 2019-12-16 |
| Oral Fluid, Plasma and Whole Pharmacokinetics and Stability Following Smoked Cannabis Cannabis Cigarette - Cannabis Use, Drug Abuse | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 45 | 2010-01-22 | 2018-07-05 |
| Pilot Study Repetitive Transcranial Magnetic Stimulation (rTMS) in Cannabis Craving Repetitive Transcranial Magnetic Stimulation - Cannabis Use | Phase 1 | Withdrawn | National Institute on Drug Abuse (NIDA) | 2009-08-19 | 2017-07-02 |
Marijuana Abuse (11) · Alcohol Drinking (2) · Opioid-Related Disorders (2) · Stress Disorders, Post-Traumatic (2) · Suicide (2) · Tobacco Use (2) · Acquired Immunodeficiency Syndrome (1) · Cigarette Smoking (1) · Cognitive Dysfunction (1) · Substance-Related Disorders (1) · Vaping (1)
Mental Disorders (13) · Chemically-Induced Disorders (12) · Substance-Related Disorders (11) · Behavior (6) · Behavioral Symptoms (2) · Drinking Behavior (2) · Narcotic-Related Disorders (2) · Self-Injurious Behavior (2) · Smoking (2) · Stress Disorders, Traumatic (2) · Trauma and Stressor Related Disorders (2) · Blood-Borne Infections (1) · Cognition Disorders (1) · Communicable Diseases (1) · Genital Diseases (1)
nabiximols (10) · Dronabinol (6) · Cannabidiol (2) · Analgesics, Opioid (1) · Choline (1) · Ethanol (1) · Exercise (1) · Methods (1) · Motivational Interviewing (1) · Phosphatidylcholines (1) · Rice Bran Oil (1) · Single Person (1) · Transcranial Magnetic Stimulation (1) · beta-myrcene (1) · lorcaserin (1)
Johns Hopkins University (5) · National Institute on Drug Abuse (NIDA) (3) · Shanna Babalonis, PhD (2) · Yale University (2) · Germans Trias i Pujol Hospital (1) · Leslie Lundahl (1) · New York State Psychiatric Institute (1) · Unity Health Toronto (1) · University of Colorado, Denver (1) · University of Kentucky (1) · Washington State University (1) · Wayne State University (1)
United States (18) · Canada (1) · Spain (1)
Dustin Lee, PhD (2) · Marilyn Huestis, Ph.D. (2) · Shanna Babalonis, PhD (2) · Amy C Justice, MD, PhD (1) · Carrie Cuttler, PhD (1) · Deepak C D'Souza, MBBS, MD (1) · Dustin C Lee, PhD (1) · M. Camille Hoffman, MD (1) · Ryan J McLaughlin, PhD (1) · Ryan Vandrey, PhD (1) · Sharon Hunter, PhD (1) · Tom Schweizer, PhD (1) · Tory Spindle, PhD (1)
PMID 27899456, PMID 28138971, PMID 28188235, PMID 33155722, PMID 33298281, PMID 33322849, PMID 33451073
R01DA058624 (2), P01AA029545 (1), R01DA043475 (1), R01DA057201 (1), R21DA045101 (1), R21DA056687 (1)