26 completed, 7 unknown, 6 recruiting, 3 active not recruiting. 19 Not applicable, 10 Phase 2, 5 Phase 1, 5 Phase 3, 5 Phase 4.
Follow Choline: new trials by email Literature Review of Choline trials Research Report on Choline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study of Prenatal Choline Supplementation Placebo, Choline bitartrate - Brain Development, Choline Nutrition | Phase 2 | Recruiting | Wayne State University | 50 | 2026-07-08 | 2026-07-14 |
| Study of Choline Chloride for Injection in Adolescent and Adult Patients With Intestinal Failure Receiving Long Term Parenteral Support Choline Chloride for Injection, Placebo - Choline Deficiency, Liver Injury | Phase 2 / Phase 3 | Recruiting | Protara Therapeutics | 129 | 2025-12-10 | 2026-08-24 |
| Choline and Iron Deficiency choline bitartrate, placebo drug - Pediatric Iron Deficiency, Anemia | Phase 2 / Phase 3 | Recruiting | University of Minnesota | 300 | 2025-08-11 | 2026-08-05 |
| Maternal Choline Supplementation and Cannabis Use During Pregnancy: Impact on Early Brain Development Placebo, Choline - Child Development, Cannabis Use | Phase 1 | Recruiting | University of Colorado, Denver | 140 | 2024-11-25 | 2025-02-03 |
| Choline Dose Ranging in Postmenopausal Women Choline, Placebo - Menopause | Not applicable | Completed | Julie Dumas | 20 | 2024-09-01 | 2026-05-04 |
| Choline Effects - Pre-symptomatic AD Choline - Alzheimer Disease | Phase 1 | Completed | Paul E Schulz | 15 | 2023-06-26 | 2026-04-22 |
| RCT of Prenatal Choline Supplementation During Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure Choline bitartrate, Placebo - Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome | Phase 2 | Recruiting | Wayne State University | 288 | 2023-04-13 | 2026-07-09 |
| Effects of a Nutraceutic Compound on Cognitive Impairment Placebo oral vial, Choline Bitartrate - Mild Cognitive Impairment | Phase 4 | Completed | Federico II University | 58 | 2022-09-01 | 2024-01-11 |
| Reverse Triple Negative Immune Resistant Breast Cancer Choline, anti-PD-1 antibody and chemotherapy, Sodium Cromoglicate - Triple-negative Breast Cancer | Phase 2 | Recruiting | Fudan University | 80 | 2022-06-30 | 2025-12-03 |
| Choline and Brain Functioning in Postmenopausal Women Choline, Placebo - Menopause | Not applicable | Completed | University of Vermont | 38 | 2022-06-15 | 2025-12-04 |
| Dietary Allowance of Methyl Donor Nutrients to Minimize Risks of Non-alcoholic Fatty Liver Progression Folic acid, choline chloride - Non-alcoholic Fatty Liver Disease | Not applicable | Completed | Fu Jen Catholic University Hospital | 51 | 2022-04-25 | 2026-04-14 |
| The Effects of Dihydromiricetin on MASLD Dihydromiricetin, Vitamin C, E and Choline, Placebo - NAFLD | Not applicable | Completed | University of Athens | 55 | 2021-11-01 | 2025-05-21 |
| Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Study Choline Bitartrate - Fetal Alcohol Spectrum Disorders | Phase 2 | Active not recruiting | Jeff Wozniak | 62 | 2021-10-22 | 2026-07-08 |
| Choline and Cardiometabolic Health Choline, Placebo - Cardiovascular Risk Factor | Not applicable | Completed | Virginia Polytechnic Institute and State University | 14 | 2021-08-20 | 2025-05-31 |
| Effects of Increased Maternal Choline Intake on Child Cognitive Development 550 mg/day Choline, 25 mg/day Choline - Pregnancy | Not applicable | Active not recruiting | Cornell University | 40 | 2020-12-13 | 2024-10-02 |
| Nutritional Support and Prophylaxis Doses of Azithromycin for Pregnant Women - Mumta Pregnant Women Trial Balanced-energy protein (BEP), Azithromycin Tablets, Choline Bitartrate - Undernutrition | Not applicable | Unknown | Vital Pakistan Trust | 1884 | 2019-07-22 | 2022-10-13 |
| S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease formulation containing S-Adenosyl methionine and choline, Placebo - Alcoholic Liver Diseases | Not applicable | Unknown | University Clinic Dr Dragisa Misovic-Dedinje | 44 | 2019-05-09 | 2019-05-29 |
| Short Term Choline and Cardiovascular Health Choline, Placebo - Cardiovascular Risk Factor | Not applicable | Completed | Virginia Polytechnic Institute and State University | 20 | 2019-05-08 | 2026-03-27 |
| Plasma TMAO and Choline Levels in Individuals With Metabolic Syndrome - Comparison Between Eggs and Choline Supplement. Eggs - Coronary Artery Disease, Diabetes | Not applicable | Completed | University of Connecticut | 25 | 2018-11-01 | 2020-11-03 |
| Choline Supplementation and Cardiovascular Health Choline, Placebo - Cardiovascular Risk Factor | Not applicable | Completed | Virginia Polytechnic Institute and State University | 29 | 2018-09-24 | 2026-03-27 |
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Fetal Alcohol Spectrum Disorders (5) · Fatty Liver (3) · Non-alcoholic Fatty Liver Disease (3) · Hyperphagia (2) · Metabolic Syndrome (2) · Alcohol-Induced Disorders (1) · Alcohol-Related Disorders (1) · Alzheimer Disease (1) · Anemia (1) · Autistic Disorder (1) · Breast Feeding (1) · Choline Deficiency (1) · Cognitive Dysfunction (1) · Coronary Artery Disease (1) · Diabetes Mellitus (1)
Cornell University (3) · University of Colorado, Denver (3) · University of Minnesota (3) · Virginia Polytechnic Institute and State University (3) · Columbia University (2) · The Cleveland Clinic (2) · Wayne State University (2) · Bambino Gesù Hospital and Research Institute (1) · Federico II University (1) · Fu Jen Catholic University Hospital (1) · Fudan University (1) · Institut Paoli-Calmettes (1) · Jeff Wozniak (1) · Julie Dumas (1) · Northwestern University (1)
United States (26) · Italy (2) · Romania (2) · South Africa (2) · Bangladesh (1) · Belgium (1) · China (1) · Denmark (1) · France (1) · Germany (1) · Greece (1) · Israel (1) · Pakistan (1) · Poland (1) · Serbia (1)
Jeffrey R Wozniak, Ph.D. (3) · Kevin Davy, PhD (3) · Joseph L Jacobson, PhD (2) · R. Colin Carter, MD, MMSc (2) · Sandra W Jacobson, PhD (2) · Alan Lewis Buchman (1) · Ameer Muhammad, MSc (1) · Barbara J Strupp, PhD (1) · Camille Hoffman, MD (1) · Dorit Ben-Shalom, Ph.D (1) · Ernesta M Meinjtes, PhD (1) · Ernesta M Meintjes, PhD (1) · Fyezah Jehan, MSc (1) · Georgios Papatheodoridis, MD PhD (1)
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R01AA024123 (2), R21AA019580 (1), R21AG067380 (1), R21AT004708 (1)