17 recruiting. 17 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Recruiting 17 |
| Phase 2 | 5 | Recruiting 5 |
Follow Brain Injuries: new trials by email Literature Review of Brain Injuries trials Research Report on Brain Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI) Virtual Reality, Standard Psychotherapy - Traumatic Brain Injuries, TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Johns Hopkins University | 30 | 2026-10-01 | 2026-10-26 |
| ENGAGE-TBI Feasibility Study Social intervention study for TBI survivors - TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Washington University School of Medicine | 30 | 2026-08-17 | 2026-08-18 |
| Feasibility of SUPPORT-TBI SUPPORT-TBI - TBI Traumatic Brain Injury | Phase 1 | Recruiting | Washington University School of Medicine | 60 | 2026-08-17 | 2026-08-19 |
| Neonatal White Matter Injury Trial (WRAP) Clemastine fumarate - White Matter Injury, Brain Injury, Fetus and Neonate | Phase 1 | Recruiting | Bridget LaMonica Ostrem, M.D., Ph.D. | 24 | 2026-07-26 | 2026-07-28 |
| Monitoring Patients With Repetitive Head Impact With Gamma-glutamylcysteine Supplementation Gamma-glutamylcysteine (GGC) - Repetitive Head Impacts | Phase 1 | Recruiting | Pravat Mandal | 30 | 2026-05-01 | 2026-06-03 |
| Low-Tech Treatments for Obstructive Sleep Apnea High-Resistance Breathing and Drinking Exercises, Low-Resistance Breathing and Drinking Exercises - Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI) | Phase 1 / Phase 2 | Recruiting | Uniformed Services University of the Health Sciences | 60 | 2026-01-29 | 2026-09-10 |
| Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy Psilocybin - Persisting Symptoms After Concussion | Phase 1 | Recruiting | University of Calgary | 40 | 2025-05-27 | 2026-09-09 |
| Regulation of Emotion, Sleep Extension, and mTBI Sleep Extension - Mild Traumatic Brain Injury | Phase 1 | Recruiting | Merrimack College | 60 | 2025-02-01 | 2025-04-09 |
| Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury control, propranolol, Carvedilol - TBI Traumatic Brain Injury | Phase 1 / Phase 2 | Recruiting | Mansoura University | 100 | 2025-01-20 | 2025-04-02 |
| DBS for Cognitive Deficits After Traumatic Brain Injury Deep Brain Stimulation - TBI Traumatic Brain Injury | Phase 1 | Recruiting | Sunnybrook Health Sciences Centre | 10 | 2024-11-01 | 2025-02-11 |
| Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury Angiotensin (1-7), Sterile saline - Traumatic Brain Injury | Phase 1 / Phase 2 | Recruiting | University of Arizona | 90 | 2024-05-28 | 2026-08-11 |
| Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury intermittent theta burst stimulation, placebo intermittent theta burst stimulation - Mild Traumatic Brain Injury, Suicidal Ideation | Phase 1 | Recruiting | VA Office of Research and Development | 55 | 2024-05-20 | 2026-04-14 |
| Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury Hyperpolarized 13C-Pyruvate - Traumatic Brain Injury, Subarachnoid Hemorrhage | Phase 1 | Recruiting | University of Maryland, Baltimore | 15 | 2023-10-26 | 2025-05-11 |
| Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches Repetitive Transcranial Magnetic Stimulation, Sham Repetitive Transcranial Magnetic Stimulation - Brain Concussion, Mild Traumatic Brain Injury | Phase 1 | Recruiting | State University of New York - Upstate Medical University | 60 | 2023-10-23 | 2025-10-10 |
| Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury KF-mSMT Plus Aerobic Exercise Training, KF-mSMT Plus Stretching Exercise Training - Traumatic Brain Injury | Phase 1 | Recruiting | Kessler Foundation | 60 | 2023-04-21 | 2025-09-04 |
| Modulating Exercise Dosage to Improve Concussion Recovery High Dose Exercise - Concussion, Brain, Treatment | Phase 1 / Phase 2 | Recruiting | University of Colorado, Denver | 178 | 2022-08-05 | 2026-08-31 |
| A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity. Corabotase, Placebo, Dysport - Spasticity | Phase 1 / Phase 2 | Recruiting | Ipsen | 240 | 2021-04-29 | 2026-07-28 |
Brain Injuries, Traumatic (12) · Brain Concussion (6) · Anxiety Disorders (1) · Brain Diseases (1) · Chronic Pain (1) · Combat Disorders (1) · Craniocerebral Trauma (1) · Depression (1) · Emotional Regulation (1) · Headache (1) · Impulsive Behavior (1) · Inflammation (1) · Leukomalacia, Periventricular (1) · Mental Disorders (1)
Central Nervous System Diseases (17) · Nervous System Diseases (17) · Trauma, Nervous System (17) · Wounds and Injuries (17) · Brain Diseases (16) · Craniocerebral Trauma (16) · Head Injuries, Closed (6) · Wounds, Nonpenetrating (6) · Pathological Conditions, Signs and Symptoms (4) · Behavior (3) · Brain Injuries, Traumatic (3) · Behavioral Symptoms (2) · Cardiovascular Diseases (2) · Cerebrovascular Disorders (2)
Acetates (1) · Carvedilol (1) · Clemastine (1) · Deep Brain Stimulation (1) · Exercise (1) · Propranolol (1) · Psilocybin (1) · Transcranial Magnetic Stimulation (1) · abobotulinumtoxinA (1) · angiotensin I (1-7) (1) · gamma-glutamylcysteine (1)
Washington University School of Medicine (2) · Bridget LaMonica Ostrem, M.D., Ph.D. (1) · Ipsen (1) · Johns Hopkins University (1) · Kessler Foundation (1) · Mansoura University (1) · Merrimack College (1) · Pravat Mandal (1) · State University of New York - Upstate Medical University (1) · Sunnybrook Health Sciences Centre (1) · Uniformed Services University of the Health Sciences (1) · University of Arizona (1) · University of Calgary (1) · University of Colorado, Denver (1) · University of Maryland, Baltimore (1)
United States (14) · Canada (2) · Austria (1) · Bulgaria (1) · Czechia (1) · Egypt (1) · France (1) · Germany (1) · Hungary (1) · Italy (1) · Japan (1) · Poland (1) · Portugal (1) · Russia (1) · South Korea (1)
Alexandra L Aaronson, MD (1) · Bridget Ostrem, MD, PhD (1) · Chantel T Debert, MD MSc FRCPC (1) · David R Howell, PhD (1) · Dirk Mayer, Dr. rer. nat. (1) · Durga Roy, MD (1) · Jessica Kersey, PhD, OTR/L (1) · Magnotti Louis, MD (1) · Nancy D Chiaravalloti, PhD (1) · Nir Lipsman, MD PhD (1) · Pravat K Mandal, PhD (1) · Saumik Das (1) · Yi-Ling Kuo, PT, PhD (1)
PMID 39671573, PMID 39760650, PMID 40297050, PMID 40887012, PMID 40990413, PMID 41019467, PMID 41593831, PMID 41622533, PMID 41956449, PMID 42245142, PMID 42284615
1DP2NS148743-01 (1), KL2TR002346 (1), R01HD108133 (1), R15MH136612 (1)