21 terminated. 21 Phase 2, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 21 | Terminated 21 |
| Phase 3 | 3 | Terminated 3 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BHV-7000 Open-Label Extension Bipolar Mania Study BHV-7000 - Bipolar Disorder | Phase 2 | Terminated | Biohaven Therapeutics Ltd. | 94 | 2024-06-24 | 2025-12-16 |
| Phase 2 Clinical Trial of GH001 in Bipolar II Disorder GH001 - Bipolar II Disorder | Phase 2 | Terminated | GH Research Ireland Limited | 6 | 2023-04-06 | 2025-02-18 |
| Cannabidiol as an Adjunctive Treatment for Bipolar Depression Cannabidiol, Placebo - Bipolar Disorder, Bipolar Depression | Phase 2 / Phase 3 | Terminated | Hospital de Clinicas de Porto Alegre | 36 | 2017-11-01 | 2021-07-02 |
| The UTHealth Ketamine Project Ketamine - Treatment Resistant Depression, Major Depressive Disorder | Phase 2 | Terminated | The University of Texas Health Science Center, Houston | 10 | 2016-11-07 | 2020-11-24 |
| NeoSync TMS Treatment for Bipolar I Depression NEST (NeoSync EEG Synchronized TMS) - Major Depressive Episode, Bipolar Depression | Phase 2 | Terminated | Butler Hospital | 6 | 2016-05-01 | 2020-04-09 |
| Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder Nitrous Oxide, Midazolam - Bipolar Disorder | Phase 2 | Terminated | Sunnybrook Health Sciences Centre | 25 | 2015-08-01 | 2023-04-06 |
| Lithium for Suicidal Behavior in Mood Disorders Lithium, Placebo - Depressive Disorder, Bipolar Disorder | Phase 2 / Phase 3 | Terminated | VA Office of Research and Development | 519 | 2015-07-08 | 2024-04-29 |
| Asenapine for Bipolar Depression Asenapine, Placebo - Bipolar Depression | Phase 2 | Terminated | University of Cincinnati | 51 | 2013-09-01 | 2017-07-24 |
| Adjunctive Curcumin for Symptomatic Adolescents With Bipolar Disorder: Brain and Body Considerations Curcumin - Bipolar Disorder | Phase 2 | Terminated | Sunnybrook Health Sciences Centre | 7 | 2013-09-01 | 2018-07-24 |
| The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression Bifidobacterium infantis, Placebo - Bipolar Depression | Phase 2 | Terminated | Women's College Hospital | 16 | 2013-05-01 | 2018-11-08 |
| Adjunctive Isradipine for the Treatment of Bipolar Depression Isradipine, Placebo - Bipolar Disorder | Phase 2 | Terminated | Massachusetts General Hospital | 2 | 2013-02-01 | 2017-04-20 |
| Simvastatin Augmentation of Lithium Treatment in Bipolar Depression Simvastatin, Placebo - Bipolar Disorder | Phase 2 | Terminated | Massachusetts General Hospital | 4 | 2012-08-01 | 2017-05-09 |
| Intranasal Ketamine In the Treatment of Pediatric Bipolar Disorder Ketamine hydrochloride injection, Flat tonic water (e.g., Canada Dry Tonic Water) - Bipolar Disorder | Phase 2 / Phase 3 | Terminated | Juvenile Bipolar Research Foundation | 5 | 2012-07-01 | 2017-03-16 |
| Zonisamide for Heavy Drinkers With Bipolar Disorder Zonisamide, Placebo - Alcohol Use Disorders, Bipolar Disorder | Phase 2 | Terminated | Yale University | 3 | 2012-05-01 | 2017-01-13 |
| Efficacy and Safety of Lu AA39959 in Patients With Bipolar Depression Lu AA39959, Placebo, Quetiapine - Bipolar Disorder | Phase 2 | Terminated | H. Lundbeck A/S | 105 | 2008-12-01 | 2014-05-28 |
| Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Riluzole - Bipolar Disorder, Anxiety Disorders | Phase 2 | Terminated | National Institute of Mental Health (NIMH) | 6 | 2008-11-01 | 2017-09-15 |
| Efficacy and Safety of Lu AA34893 in Patients With Bipolar Depression Lu AA34893, Quetiapine fumarate, Placebo - Depression in Patients With Bipolar Disorder | Phase 2 | Terminated | H. Lundbeck A/S | 166 | 2008-01-01 | 2010-09-27 |
| The Antidepressant Efficacy of the Anticholinergic Scopolamine Scopolamine - Unipolar Depression, Bipolar Depression | Phase 2 | Terminated | National Institute of Mental Health (NIMH) | 17 | 2006-08-01 | 2016-11-10 |
| Clinical Trial of a Nutritional Supplement in Adults With Bipolar Disorder MCN36 (nutritional supplement), Placebo - Bipolar Disorder | Phase 2 | Terminated | University of Calgary | 40 | 2005-04-01 | 2012-09-18 |
| Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies Scopolamine Nasal Spray - Mood Disorders, Healthy | Phase 2 | Terminated | National Institute of Mental Health (NIMH) | 197 | 2003-02-27 | 2021-03-22 |
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Depression (10) · Mania (4) · Mood Disorders (4) · Depressive Disorder (3) · Depressive Disorder, Major (3) · Alcoholism (1) · Anxiety Disorders (1) · Depressive Disorder, Treatment-Resistant (1) · Suicide (1) · Suicide, Attempted (1)
Bipolar and Related Disorders (21) · Mental Disorders (21) · Mood Disorders (17) · Behavior (11) · Behavioral Symptoms (11) · Nervous System Diseases (4) · Neurobehavioral Manifestations (4) · Neurologic Manifestations (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Alcohol-Related Disorders (1) · Chemically-Induced Disorders (1) · Depressive Disorder (1) · Self-Injurious Behavior (1) · Substance-Related Disorders (1)
Ketamine (2) · Quetiapine Fumarate (2) · Riluzole (2) · Cannabidiol (1) · Curcumin (1) · Dietary Supplements (1) · Isradipine (1) · Lithium (1) · Methoxydimethyltryptamines (1) · Midazolam (1) · Nitrous Oxide (1) · Scopolamine (1) · Simvastatin (1) · Sugars (1) · Zonisamide (1)
National Institute of Mental Health (NIMH) (4) · H. Lundbeck A/S (2) · Massachusetts General Hospital (2) · Sunnybrook Health Sciences Centre (2) · Biohaven Therapeutics Ltd. (1) · Butler Hospital (1) · GH Research Ireland Limited (1) · Hospital de Clinicas de Porto Alegre (1) · Juvenile Bipolar Research Foundation (1) · The University of Texas Health Science Center, Houston (1) · University of Calgary (1) · University of Cincinnati (1) · VA Office of Research and Development (1) · Women's College Hospital (1) · Yale University (1)
United States (15) · Canada (5) · Germany (2) · United Kingdom (2) · Australia (1) · Austria (1) · Belgium (1) · Brazil (1) · Bulgaria (1) · France (1) · Lithuania (1) · Malaysia (1) · Netherlands (1) · Philippines (1) · Poland (1)
Benjamin I Goldstein, MD (2) · Carlos A Zarate, M.D. (2) · Roy H Perlis, MD, MSc (2) · Albert J Arias, MD (1) · Bonnie J Kaplan, PhD (1) · Caleb M Adler, MD (1) · Demitri Papolos, MD (1) · Ellen Leibenluft, MD (1) · Ira R Katz, MD PhD (1) · Linda Carpenter, MD (1) · Maura L Furey, Ph.D. (1) · Salih Selek, MD (1) · Valerie Taylor, PhD (1)
PMID 20074703, PMID 23364679, PMID 27366831, PMID 28338546, PMID 30184133, PMID 32637725, PMID 34787653, PMID 35092868, PMID 36579458, PMID 37920963
K23AA017689 (1)