11 completed, 1 terminated, 1 unknown. 5 Phase 2, 4 Phase 1, 2 Not applicable, 2 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Terminated 1 |
| Phase 1 | 4 | Completed 4 |
| Not applicable | 2 | Completed 1, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
| Early Phase 1 | 1 | Completed 1 |
Follow Isradipine: new trials by email Literature Review of Isradipine trials Research Report on Isradipine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation Isradipine, Cue Exposure - Nicotine Dependence, Smoking, Cigarette | Early Phase 1 | Completed | Jasper A. Smits | 78 | 2020-01-22 | 2026-06-15 |
| ACEI or ARB and COVID-19 Severity and Mortality in US Veterans ACEI/ARB, Non-ACEI/ARB, ACEI - Hypertension, COVID | Completed | University of Utah | 22213 | 2020-01-19 | 2021-04-28 | |
| Efficacy of Isradipine in Early Parkinson Disease Isradipine, Placebo (for Isradipine) - Parkinson Disease | Phase 3 | Completed | University of Rochester | 336 | 2014-11-01 | 2020-01-14 |
| Improving Buprenorphine Detoxification Outcomes With Isradipine Isradipine, Placebo - Opioid Dependence | Phase 1 / Phase 2 | Completed | University of Arkansas | 28 | 2013-10-01 | 2017-06-05 |
| Adjunctive Isradipine for the Treatment of Bipolar Depression Isradipine, Placebo - Bipolar Disorder | Phase 2 | Terminated | Massachusetts General Hospital | 2 | 2013-02-01 | 2017-04-20 |
| Evaluating Isradipine for Cognitive Enhancement in Schizophrenia and Schizoaffective Disorder isradipine - Schizophrenia, Schizoaffective Disorder | Not applicable | Completed | Icahn School of Medicine at Mount Sinai | 11 | 2012-09-01 | 2018-12-05 |
| Reduction of Night-time Blood Pressure in Pediatric Renal Transplant Recipients New Medication: Enalapril, Isradipine, Propranolol - Hypertension Secondary to Kidney Transplant | Phase 2 / Phase 3 | Completed | Northwell Health | 33 | 2009-11-01 | 2021-04-13 |
| Safety, Tolerability and Efficacy Assessment of Dynacirc CR in Parkinson Disease Isradipine CR 5mg, Isradipine CR 10mg, Isradipine CR 20mg - Parkinson Disease | Phase 2 | Completed | Northwestern University | 99 | 2009-07-01 | 2013-04-17 |
| Impact of Persistent Conductances on Motor Unit Firing in SCI sugar pill, Riluzole, Isradipine - Chronic Spinal Cord Injury | Not applicable | Unknown | Shirley Ryan AbilityLab | 50 | 2009-06-01 | 2014-05-13 |
| Drug Discrimination in Methadone-Maintained Humans Study 2 2-4 of the drugs listed below - Opioid Dependence | Phase 1 | Completed | University of Arkansas | 15 | 2008-08-01 | 2012-04-18 |
| Parkinson's Disease Isradipine Safety Study Dynacirc CR (Isradipine) - Parkinson's Disease | Phase 2 | Completed | Northwestern University | 31 | 2008-04-01 | 2021-11-15 |
| An Open-Label, Randomized, Comparative 3-Way Cross-Over Study to Evaluate the Effect of Food on the 24-Hour Intragastric pH at Day 5 After Twice Daily Oral Administration of PN 200 (Omeprazole/Naproxen) in Healthy Volunteers PN 200 - Healthy | Phase 1 | Completed | POZEN | 24 | 2007-01-01 | 2008-04-22 |
| Drug Discrimination in Methadone-Maintained Humans Study 1 Cycloserine, Diltiazem, Gabapentin - Drug Dependence | Phase 1 | Completed | University of Arkansas | 40 | 2006-09-01 | 2011-03-11 |
Opioid-Related Disorders (3) · Parkinson Disease (3) · Bipolar Disorder (1) · Cigarette Smoking (1) · Depression (1) · Hypertension (1) · Psychotic Disorders (1) · Schizophrenia (1) · Smoking (1) · Smoking Cessation (1) · Smoking Reduction (1) · Spinal Cord Injuries (1) · Substance-Related Disorders (1) · Tobacco Use Disorder (1)
University of Arkansas (3) · Northwestern University (2) · Icahn School of Medicine at Mount Sinai (1) · Jasper A. Smits (1) · Massachusetts General Hospital (1) · Northwell Health (1) · POZEN (1) · Shirley Ryan AbilityLab (1) · University of Rochester (1) · University of Utah (1)
United States (12) · Canada (2)
Alison Oliveto, PhD (2) · Adam P Bress, PharmD, MS (1) · Alison Oliveto, Ph.D. (1) · Cara C Young, Ph.D. (1) · Christine B Sethna, MD, EdM (1) · David Taylor (1) · Jasper AJ Smits, Ph.D. (1) · Katherine Burdick, PhD (1) · Robert Holloway, MD MPH (1) · Roy H Perlis, MD, MSc (1) · Tanya Simuni, M.D. (1) · Tanya Simuni, MD (1) · Tanya Simuni, MS (1)
PMID 30741695, PMID 32227247, PMID 33281447, PMID 33460320, PMID 33891615, PMID 36865634, PMID 38789642, PMID 39082471, PMID 40272204
R01DA010017 (2), R21DA035325 (1), R21DA049539 (1), U01NS080818 (1), U01NS080840 (1)