580 completed, 166 unknown, 89 terminated, 64 recruiting. 984 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 984 | Completed 580, Unknown 166, Terminated 89, Recruiting 64, Not yet recruiting 38, Withdrawn 31, Active not recruiting 14, Enrolling by invitation 2 |
Follow Arthritis: new trials by email Literature Review of Arthritis trials Research Report on Arthritis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Zynrelef Versus Adductor Canal Block ZYNRELEF 400Mg-12Mg Extended-Release Solution, Ultrasound-Guided Adductor Canal Block, Ropivacaine 0.5% Injectable Solution - Knee Osteoarthritis, Arthritis Knee | Phase 4 | Not yet recruiting | University of Miami | 120 | 2027-01-01 | 2026-06-12 |
| Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride? 25 gauge needle, 22 gauge needle, +/- Ethyl Chloride Topical Aerosol Anesthetic - Osteoarthritis (OA) of the Knee, Fear of Needles | Phase 4 | Not yet recruiting | University of California, Davis | 88 | 2026-12-01 | 2026-09-16 |
| Perioperative Colchicine for TKA Colchicine 1.8 mg (loading dose) + Dextrose Oral Placebo, Colchicine 1.8 mg + 0.6 mg, Dextrose Oral Placebo - Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty | Phase 4 | Not yet recruiting | Geisinger Clinic | 75 | 2026-12-01 | 2026-09-03 |
| Assessing the Time-Course of Dexmedetomidine-Induced Analgesia Via EEG Preemptive Analgesia Of Dexmedetomidine - Total Hip Arthroplasty (THA), Intrathecal Anesthesia | Phase 4 | Not yet recruiting | China International Neuroscience Institution | 20 | 2026-11-25 | 2026-09-10 |
| Withdrawal Versus Continued TNF Inhibitor Monotherapy Treatment in Children With Inactive Juvenile Idiopathic Arthritis Adalimumab, Etanercept, Golimumab - Juvenile Idiopathic Arthritis (JIA) | Phase 4 | Not yet recruiting | Oslo University Hospital | 90 | 2026-11-11 | 2026-11-12 |
| A Pragmatic Trial of Interleukin-17 Inhibition Versus Janus Kinase Inhibition After Tumor Necrosis Factor-alpha Inhibitor Failure in Axial Spondyloarthritis Secukinumab (IL-17i ), Upadacitinib (JAKi) - Axial Spondyloarthritis (AxSpA) | Phase 4 | Not yet recruiting | The University of Texas Health Science Center, Houston | 40 | 2026-11-01 | 2026-10-14 |
| Ivarmacitinib With or Without Celecoxib for Ankylosing Spondylitis Ivarmacitinib with celecoxib, Ivarmacitinib Monotherapy - Ankylosing Spondylitis (AS) | Phase 4 | Not yet recruiting | Peking University Third Hospital | 138 | 2026-10-25 | 2026-10-27 |
| E-Type - Early Wear of Polyethylene Liners Used in DMC Total Hip Arthroplasty - Osteoarthritis, Osteonecrosis | Phase 4 | Recruiting | Uppsala University | 40 | 2026-10-08 | 2026-10-09 |
| Intraosseous Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty Tranexamic Acid, Normal Saline - Knee Osteoarthritis | Phase 4 | Not yet recruiting | The Second Affiliated Hospital of Kunming Medical University | 70 | 2026-10-01 | 2026-10-09 |
| GLP-1s in Hip and Knee Arthroplasty GLP-1 Receptor Agonists + Behavioral modification, Behavioral + placebo - Arthritis, Obesity & Overweight | Phase 4 | Not yet recruiting | Nova Scotia Health Authority | 100 | 2026-10-01 | 2026-08-10 |
| Mazdutide for Weight Management and Gout in Adults With Obesity Mazdutide - Gout, Obesity (BMI>30) | Phase 4 | Not yet recruiting | Hongwei Jiang | 30 | 2026-09-15 | 2026-09-17 |
| Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance Duloxetine, Placebo - Knee Osteoarthritis (Knee OA), Chronic Pain | Phase 4 | Recruiting | Benedict Alter | 85 | 2026-09-15 | 2026-10-21 |
| Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA bupivacaine-meloxicam (extended release), Bupivacaine, Ketorolac - Periarticular Block, Osteoarthritis (OA) | Phase 4 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 150 | 2026-09-03 | 2026-10-28 |
| A Clinical Trial of Antiplatelets in Psoriasis Aspirin, Clopidogrel, Placebo - Psoriasis (PsO), Psoriatic Arthritis (PsA) | Phase 4 | Not yet recruiting | NYU Langone Health | 60 | 2026-09-01 | 2026-08-05 |
| Extended Post-operative Oral TXA in Primary THA Extended oral tranexamic acid regimen, Placebo - Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee | Phase 4 | Not yet recruiting | Oregon Health and Science University | 170 | 2026-09-01 | 2026-07-08 |
| A Remotely Conducted Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are Receiving TREMFYA Therapeutically Breast Milk Sample Collection, Guselkumab - Psoriasis, Colitis, Ulcerative | Phase 4 | Recruiting | Janssen Research & Development, LLC | 10 | 2026-08-07 | 2026-11-03 |
| Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study) triamcinolone acetonide (Kenalog), Celestone Soluspan 6Mg/Ml Suspension for Injection, Depo-Medrol 40Mg/Ml Suspension for Injection - Back Pain Lower Back, Neck Pain | Phase 4 | Recruiting | Igor Wilderman. MD | 500 | 2026-07-30 | 2026-08-13 |
| The Impact of Initiating Dotinurad Urate-Lowering Therapy at Different Time Windows on Gout Flare Resolution Time Dotinurad, colchicine, etoricoxib - Gout | Phase 4 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 142 | 2026-07-30 | 2026-06-22 |
| Discontinuation of Disease-modifying Anti-rheumatic Drugs (DMARDs) in Rheumatoid Arthritis Patients Also Using TNF Inhibitors Strategy to attempt discontinuation of MTX or LEF (and restart when necessary), Continuation of MTX or LEF - Rheumatoid Arthritis (RA) | Phase 4 | Recruiting | Sint Maartenskliniek | 202 | 2026-07-14 | 2026-09-03 |
| Comparison of Effectiveness and Safety of Tofacitinib Versus Upadacitinib as Add-on to Methotrexate in Rheumatoid Arthritis JAK inhibitor(tofacitinib/upadacitinib) as advised by the rheumatologist as add on to 25 mg methotrexate - Rheumatoid Arthritis (RA) | Phase 4 | Not yet recruiting | Sheikh Zayed Federal Postgraduate Medical Institute | 100 | 2026-07-05 | 2026-06-09 |
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Arthritis, Rheumatoid (325) · Osteoarthritis (238) · Osteoarthritis, Knee (227) · Spondylitis, Ankylosing (59) · Osteoarthritis, Hip (50) · Arthritis, Psoriatic (48) · Pain (42) · Gout (31) · Arthritis, Juvenile (25) · Pain, Postoperative (25) · Osteonecrosis (23) · Spondylarthritis (22) · Axial Spondyloarthritis (18) · Hip Dislocation, Congenital (17)
Musculoskeletal Diseases (983) · Joint Diseases (972) · Rheumatic Diseases (835) · Skin and Connective Tissue Diseases (413) · Connective Tissue Diseases (364) · Immune System Diseases (364) · Autoimmune Diseases (359) · Osteoarthritis (235) · Bone Diseases (172) · Pathological Conditions, Signs and Symptoms (163) · Spinal Diseases (134) · Spondylitis (131) · Spondylarthritis (111) · Spondylarthropathies (111)
Methotrexate (97) · Etanercept (86) · Adalimumab (78) · Sodium Chloride (46) · tocilizumab (39) · Infliximab (37) · Ropivacaine (36) · Celecoxib (33) · Dexamethasone (27) · Saline Solution (25) · Abatacept (22) · Hyaluronic Acid (21) · Rituximab (20) · Sulfasalazine (20) · tofacitinib (19)
Hoffmann-La Roche (29) · DePuy International (28) · Amgen (24) · Poznan University of Medical Sciences (21) · Pfizer (17) · Wyeth is now a wholly owned subsidiary of Pfizer (17) · Ewha Womans University (14) · Seoul National University Hospital (13) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (11) · University of Sao Paulo General Hospital (11) · Hospital for Special Surgery, New York (10) · Merck Sharp & Dohme LLC (10) · Federal University of São Paulo (9) · Sun Yat-sen University (9) · Brigham and Women's Hospital (8)
United States (243) · China (71) · United Kingdom (64) · France (63) · South Korea (61) · Canada (60) · Germany (59) · Italy (49) · Denmark (48) · Spain (44) · Poland (43) · Netherlands (40) · Brazil (34) · Taiwan (30) · Australia (29)
Young-Hoo Kim, MD (7) · Malgorzata Reysner, M.D. Ph.D. (6) · Ru-Lan Hsieh, MD (4) · Elizaveta Kon, MD (3)
PMID 27338778, PMID 31277720, PMID 36269595, PMID 18050189, PMID 22150039, PMID 22227789, PMID 23325966, PMID 24907147, PMID 25359382, PMID 25889222, PMID 26729950, PMID 27432356, PMID 28255449, PMID 28376912, PMID 28814431, PMID 31985507, PMID 32025629, PMID 36600185, PMID 36601090, PMID 36931693, PMID 38488976, PMID 39192350, PMID 42261247, PMID 10422923, PMID 10776835, PMID 1101375, PMID 11020772, PMID 11354213, PMID 11429362, PMID 11589257, PMID 11808971, PMID 11890313, PMID 12098173, PMID 12538372, PMID 15029544, PMID 15480678, PMID 15534532, PMID 15596866, PMID 15701214, PMID 15712981, PMID 15958159, PMID 15992136, PMID 16083527, PMID 16152868, PMID 16168037, PMID 16271901, PMID 16288617, PMID 16568327, PMID 16572283, PMID 16651569
2014 (8), 2016 (7), 2005 (6), 2009 (6), 2015 (6), 2023 (6), 2017 (5), 2018 (4), 2025 (4), 2008 (3), 2004 (1), 2019 (1), K23AR057578 (1), K23HL152013 (1), K23NS123429 (1)