19 completed, 9 recruiting, 9 unknown, 3 not yet recruiting. 19 Not applicable, 5 Phase 2, 5 Phase 4, 3 Phase 1, 3 Phase 3.
Follow Acute Postoperative Pain: new trials by email Literature Review of Acute Postoperative Pain trials Research Report on Acute Postoperative Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Persistent Pain and Its Impact on Daily Life After Lung Surgery Longitudinal Assessment of Pain and Pain-Related Functional Interference - Chronic Postsurgical Pain, Acute Postoperative Pain | Not yet recruiting | Aerospace Center Hospital | 350 | 2026-10-10 | 2026-10-01 | |
| Empowered Relief for Severe Pain After Cesarean Delivery During the Inpatient Period Empowered Relief - Severe Pain, Cesarean Section Complications | Not applicable | Not yet recruiting | Stanford University | 60 | 2026-10-05 | 2026-10-02 |
| A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction CYT-1010, Placebo - Acute Postoperative Pain, Dental Pain | Phase 1 / Phase 2 | Recruiting | Cytogel Pharma, LLC | 32 | 2026-09-25 | 2026-10-29 |
| CROPS Study: Chronification of Post-Surgical Pain and Risk Assessment Standard Multimodal Opioid-Based Analgesia, Regional Anesthesia-Based Analgesia - Chronic Post-surgical Pain, Acute Postoperative Pain | Not applicable | Not yet recruiting | Kočan Ladislav | 180 | 2026-09-01 | 2026-06-05 |
| Intertransverse Process Block for Postoperative Analgesia After Thoracotomy and Lobectomy Intertransverse Process Block, Placebo - Acute Postoperative Pain, Thoracotomy Surgery | Not applicable | Completed | Konya City Hospital | 66 | 2026-04-08 | 2026-09-09 |
| DIPB vs. SIFIB for Postoperative Analgesia After Hip Surgery Suprainguinal Fascia Iliaca Block, Deep Iliacus Plane Block - Hip Arthroplasty, Postoperative Pain | Not applicable | Recruiting | Sivas Numune Hospital | 70 | 2026-03-27 | 2026-04-02 |
| Comparison of the Efficacy and Safety of Intravenous Buprenorphine Administered Via PCA System Versus Oxycodone in the Management of Postoperative Pain After Video-Assisted Thoracoscopic Surgery Group B (Buprenorphine), Group O (Oxycodone) - Acute Postoperative Pain, Chronic Postoperative Pain | Phase 4 | Recruiting | Medical University of Silesia | 200 | 2026-03-18 | 2026-09-25 |
| Intertransverse Process Block to Improve Quality of Recovery After Cardiac Surgery With Sternotomy Intertransverse process block, Sham Block, Levobupivacaine 0.25% - Acute Postoperative Pain | Not applicable | Withdrawn | Chinese University of Hong Kong | 2025-11-01 | 2026-10-23 | |
| Transcutaneous Electrical Nerve Stimulation for Acute Postoperative Pain After Video-Assisted Thoracoscopic Surgery Active TENS, Sham TENS - Acute Postoperative Pain, Thoracic Surgical Procedures | Not applicable | Recruiting | Fooyin University | 90 | 2025-08-28 | 2026-07-29 |
| Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty continuous peripheral nerve block with OnQ pump, single injection nerve block - Acute Postoperative Pain, Surgery | Phase 4 | Recruiting | University of California, San Diego | 40 | 2025-06-01 | 2025-06-17 |
| Sequential Method Determination of Oxycodone for Thoracoscope Surgery Median Effective Dose of Acute Pain Treatment Oxycodone will be administered intravenously in the group 1 - Oxycodone, Thoracoscopic Lobectomy | Not applicable | Unknown | Jianbo Wu | 60 | 2024-09-01 | 2024-08-02 |
| Clinical Prediction of Post-surgical Pain Acute Postoperative Pain, Chronic Post Operative Pain | Recruiting | Aarhus University Hospital | 748 | 2024-08-26 | 2024-10-28 | |
| Effects of tDCS and VNS on Postoperative Analgesia Active transcranial direct current stimulation, Active vagus nerve stimulation, Sham transcranial direct current stimulation - Acute Postoperative Pain | Not applicable | Unknown | Columbia University | 200 | 2024-08-01 | 2024-08-14 |
| Tapentadol vs Pregabalin for Postoperative Pain in Lower Limb Surgery Tapentadol, Pregabalin - Acute Postoperative Pain, Lower Limb Surgery | Not applicable | Completed | ISSSTE Hospital Regional "Gral. Ignacio Zaragoza" | 46 | 2024-06-19 | 2026-05-15 |
| Bupivacaine 0.125% Versus Bupivacaine 0.25% in Superficial Cervical Plexus Block for Tympanomastoid Surgeries in Adults bupivacaine 0.25%, bupivacaine 0.125% - Surgical Field, Acute Postoperative Pain | Phase 4 | Unknown | Cairo University | 60 | 2024-05-01 | 2024-05-07 |
| Modified Thoracoabdominal Nerve Plane Block In Living Liver Donors M-TAPA plane block, Postoperative pain management - Liver Failure, Acute Postoperative Pain | Not applicable | Completed | Istanbul Medipol University Hospital | 50 | 2024-04-01 | 2025-01-20 |
| Non-steroidal Anti-inflammatory in Cardiac Surgery pain management, ketoprofen, PLacebo - Acute Postoperative Pain, Non-steroidal Anti-inflammatory Drugs | Phase 3 | Recruiting | Centre Hospitalier Universitaire, Amiens | 238 | 2024-03-27 | 2025-07-23 |
| Cryoneurolysis for Acute Postoperative Pain Following Total Knee Arthroplasty Cryoneurolysis, Sham - Acute Postoperative Pain | Not applicable | Unknown | Copenhagen University Hospital, Hvidovre | 44 | 2024-03-19 | 2024-07-16 |
| A Study of the Association Between Frailty and Acute Postoperative Pain in Elderly Thoracoscopic Surgery Patients Frailty, Acute Postoperative Pain | Unknown | Huazhong University of Science and Technology | 78 | 2024-03-12 | 2024-06-21 | |
| Prospective Feasibility, Analgesic Effectiveness, and Safety Study of a Visual Analog Scale-Guided Multimodal Pain Algorithm After Posterior Rib Remodeling With Osteosynthesis VAS-Guided Multimodal Analgesia Algorithm, Ultrasound-Guided Thoracic Wall Regional Block - Acute Postoperative Pain, Chest Wall Surgery | Recruiting | Research Inc | 160 | 2024-01-01 | 2026-09-08 |
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Pain, Postoperative (42) · Pain (4) · Chronic Pain (3) · Acute Pain (1) · Agnosia (1) · Breast Neoplasms (1) · Drug-Related Side Effects and Adverse Reactions (1) · Frailty (1) · Liver Failure (1) · Motor Activity (1) · Patient Satisfaction (1) · Postoperative Cognitive Complications (1) · Postoperative Nausea and Vomiting (1) · Sleep Initiation and Maintenance Disorders (1) · Spinal Cord Neoplasms (1)
Neurologic Manifestations (42) · Pathologic Processes (42) · Pathological Conditions, Signs and Symptoms (42) · Postoperative Complications (42) · Signs and Symptoms (42) · Pain (38) · Nervous System Diseases (3) · Behavior (2) · Mental Disorders (2) · Neoplasms (2) · Neoplasms by Site (2) · Breast Diseases (1) · Central Nervous System Diseases (1) · Central Nervous System Neoplasms (1) · Chemically-Induced Disorders (1)
Saline Solution (3) · Bupivacaine (2) · Hydromorphone (2) · Morphine (2) · Pregabalin (2) · Acupuncture Therapy (1) · Anesthesia, Epidural (1) · Anesthesia, General (1) · Anesthesia, Local (1) · Antiemetics (1) · Buprenorphine (1) · Dexmedetomidine (1) · Epinephrine (1) · Esketamine (1) · Ketoprofen (1)
Cairo University (3) · Assiut University (2) · Aydin Adnan Menderes University (2) · Research Inc (2) · ACADIA Pharmaceuticals Inc. (1) · Aarhus University Hospital (1) · Aerospace Center Hospital (1) · Allay Therapeutics, Inc. (1) · Ankara City Hospital Bilkent (1) · Beijing Tiantan Hospital (1) · Benno Rehberg-Klug (1) · Centre Hospitalier Universitaire, Amiens (1) · Chinese University of Hong Kong (1) · Columbia University (1) · Copenhagen University Hospital, Hvidovre (1)
China (6) · Egypt (6) · Turkey (Türkiye) (6) · United States (5) · Australia (2) · Colombia (2) · Denmark (2) · Canada (1) · France (1) · Germany (1) · Mexico (1) · Poland (1) · Slovenia (1) · Switzerland (1) · Taiwan (1)
Alparslan Turan, Associate Prof (1) · Alparslan Turan, Associate Professor (1) · Anders H Springborg, MD (1) · Aykut Soyder, Assistant Professor (1) · Ayse Ilksen Egilmez, Specialist Doctor (1) · Benno Rehberg-Klug, MD (1) · Betul Kozanhan, Specialist Doctor (1) · Christian Jeleazcov, MD, MS (1) · Dalia S Abdelkader, assprofessor (1) · Daniel I. Sessler, Professor and Ch (1) · Edison Osorio, MD, plastic surgery (1) · Eman A Ismail, A Lectuer (1) · Fabrizio Galimberti, Medical Student (1) · FabrizioGalimberti Galimberti, Medical Student (1)
PMID 10936130, PMID 11323122, PMID 15043239, PMID 15733628, PMID 16023915, PMID 16677435, PMID 17006079, PMID 17448662, PMID 21233114, PMID 22023377, PMID 23142441, PMID 23411725, PMID 26518201, PMID 27159009, PMID 27616189, PMID 28762464, PMID 30085935, PMID 30665850, PMID 31054241, PMID 31169589, PMID 33547559, PMID 33982819, PMID 34099376, PMID 34552005, PMID 35021139, PMID 35867848, PMID 36109206, PMID 36351741, PMID 36522043, PMID 36581838, PMID 36841794, PMID 37296029, PMID 38039630, PMID 38148266, PMID 38326195, PMID 38345071, PMID 38468350, PMID 38501980, PMID 39285437, PMID 39635026, PMID 40597587, PMID 40892532, PMID 8295837
K24DA053564 (1), R90HD118650 (1)