16 completed. 16 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 16 | Completed 16 |
Follow Acid-Base Imbalance: new trials by email Literature Review of Acid-Base Imbalance trials Research Report on Acid-Base Imbalance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ephedrine Versus Norepinephrine and Fetal Acid-Base Status During Cesarean Delivery Under Spinal Anesthesia Norepinephrine, Ephedrine - Cesarean Delivery Affecting Newborn, Acidosis | Phase 4 | Completed | mehmet özkılıç | 155 | 2025-09-01 | 2026-10-08 |
| 0.9% Saline Versus Balanced Solutions in Severe Diabetic Ketoacidosis Sodium chloride 0.9% (SC), Ringer lactate (RL) - Metabolic Ketoacidosis, Ketoacidemia | Phase 4 | Completed | Tunis University | 92 | 2022-11-01 | 2024-04-12 |
| Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency SGLT2 inhibitor, Biosense Breath Ketone Analyzer - Diabetes Mellitus, Type 1 | Phase 4 | Completed | Washington University School of Medicine | 21 | 2022-10-14 | 2025-02-21 |
| Optimal Dosage of Acetazolamide for OSA Treatment Acetazolamide, Placebo - Obstructive Sleep Apnea | Phase 4 | Completed | University Hospital, Antwerp | 91 | 2021-04-20 | 2025-09-24 |
| Metabolic Responses of Dapagliflozin vs Sitagliptin in T2DM Patients Inadequately Controlled With Insulin Therapy Dapagliflozin 10 mg, Sitagliptin 100mg - Type 2 Diabetes, Ketonemia | Phase 4 | Completed | The University of Hong Kong | 60 | 2017-08-16 | 2021-04-29 |
| Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes Glargine, Continuous Glucose Monitor (Abbott FreeStyle Libre Pro) - Diabetic Ketoacidosis, Type 1 Diabetes Mellitus | Phase 4 | Completed | University of Colorado, Denver | 61 | 2017-07-21 | 2022-05-10 |
| Preserve-Transplant Study Nephrotrans, Placebo - Acidosis, Renal Insufficiency | Phase 4 | Completed | University of Zurich | 240 | 2017-06-12 | 2022-04-22 |
| Dosage Reduction and Acute Glycemic Complications in People With Type 2 Diabetes Who Fast During Ramadan Metformin and Glimepiride (Low Dosage), Metformin and Vildagliptin (Low Dosage), Metformin and Insulin Glargine U100 (Low Dosage) - Diabetes Mellitus, Type 2 | Phase 4 | Completed | University of Jordan | 687 | 2017-02-14 | 2020-02-11 |
| Alkalinization by Urologists & Nephrologists Alkali - Metabolic Acidosis, Nephrolithiasis | Phase 4 | Completed | Jean-Philippe Bertocchio | 156 | 2017-02-01 | 2020-07-14 |
| Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Vitamin B1-ratiopharm, Placebo - Heart Failure, Acidosis, Lactic | Phase 4 | Completed | Medical University of Vienna | 30 | 2012-02-01 | 2021-02-26 |
| Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Fenoldopam mesilate, Placebo - Cardiac Complications, Cardiopulmonary Bypass | Phase 4 | Completed | IRCCS Policlinico S. Donato | 80 | 2008-09-01 | 2009-04-13 |
| Does Omeprazole Decrease Intestinal Calcium Absorption? Omeprazole - Osteoporosis, Achlorhydria | Phase 4 | Completed | University of Wisconsin, Madison | 23 | 2008-01-01 | 2013-02-15 |
| Basal Insulin in the Management of Patients With Diabetic Ketoacidosis (DKA) insulin glargine+ glulisine, NPH + Regular insulin - Diabetic Ketoacidosis | Phase 4 | Completed | Emory University | 74 | 2007-12-01 | 2018-09-26 |
| Arterial pH and Total Body Nitrogen Balances in APD ammonium chloride or sodium citrate/citric acid, Sodium citrate/citratic acid - End-stage Renal Disease | Phase 4 | Completed | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 8 | 2003-09-01 | 2017-09-05 |
| Lactate Metabolism Study in HIV Infected Persons cofactor supplementation (thiamine, riboflavin, L-carnitine) - HIV Infections, AIDS | Phase 4 | Completed | Queen's University | 30 | 2002-07-01 | 2016-01-13 |
| Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis Acetazolamide, Placebo - Respiratory Insufficiency, Alkalosis | Phase 4 | Completed | University of Oslo School of Pharmacy | 70 | 2002-01-01 | 2014-01-20 |
Acidosis (5) · Diabetic Ketoacidosis (4) · Acidosis, Lactic (3) · Ketosis (3) · Diabetes Mellitus, Type 1 (2) · Diabetes Mellitus, Type 2 (2) · Achlorhydria (1) · Acquired Immunodeficiency Syndrome (1) · Acute Kidney Injury (1) · Alkalosis (1) · Body Weight (1) · Fasting (1) · Gastroesophageal Reflux (1) · HIV Infections (1) · Heart Failure (1)
Metabolic Diseases (16) · Nutritional and Metabolic Diseases (16) · Acidosis (9) · Diabetes Mellitus (6) · Endocrine System Diseases (6) · Urogenital Diseases (5) · Diabetes Complications (4) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Glucose Metabolism Disorders (4) · Kidney Diseases (4) · Male Urogenital Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Urologic Diseases (4)
Acetazolamide (2) · Citric Acid (2) · Insulin (2) · Insulin Glargine (2) · Sodium Chloride (2) · dapagliflozin (2) · Alkalies (1) · Ammonium Chloride (1) · Bicarbonates (1) · Carnitine (1) · Ephedrine (1) · Fenoldopam (1) · Metformin (1) · Norepinephrine (1) · Omeprazole (1)
Emory University (1) · IRCCS Policlinico S. Donato (1) · Jean-Philippe Bertocchio (1) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (1) · Medical University of Vienna (1) · Queen's University (1) · The University of Hong Kong (1) · Tunis University (1) · University Hospital, Antwerp (1) · University of Colorado, Denver (1) · University of Jordan (1) · University of Oslo School of Pharmacy (1) · University of Wisconsin, Madison (1) · University of Zurich (1) · Washington University School of Medicine (1)
United States (5) · Austria (1) · Belgium (1) · Canada (1) · France (1) · Hong Kong (1) · Italy (1) · Jordan (1) · Norway (1) · Switzerland (1) · Tunisia (1) · Turkey (Türkiye) (1)
Ahlem Trifi (1) · Ayman A. Zayed, MD (1) · Guillermo Umpierrez, MD (1) · Janet B McGill, MD (1) · Julie Beaume, MD (1) · Karen E Hansen, MD (1) · Kathryn Tan, MD (1) · Marco Ranucci, M.D. (1) · Michael Hiesmayr, Prof.,MD (1) · Nilufar Mohebbi, PD Dr. med. (1) · Olivier Vanderveken, MD, PhD (1) · Rajnish Mehrotra, MD (1) · Rebecca Ohman-Hanson (1)
PMID 19366972, PMID 19846545, PMID 20332738, PMID 20578215, PMID 21347742, PMID 23578004, PMID 26066773, PMID 30001705, PMID 34305809, PMID 34564842, PMID 36708734, PMID 39607014, PMID 39974120, PMID 40234173, PMID 40260699, PMID 41953463