11 completed, 5 unknown, 1 recruiting, 1 terminated. 7 Not applicable, 3 Phase 3, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 5, Unknown 2 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Phase 2 | 1 | Terminated 1 |
| Phase 4 | 1 | Completed 1 |
Follow Alkalosis: new trials by email Literature Review of Alkalosis trials Research Report on Alkalosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Re-Adjustment of Sweep Gas Flow to the During the Rewarming Period of the Cardiopulmonary Bypass Gas Flow Adjustment - Optimal Sweep Gas Flow, Determination of Optimal Sweep Gas Flow for Different Phases of Cardiopulmonary Bypass | Recruiting | Acıbadem Atunizade Hospital | 90 | 2023-08-07 | 2023-08-28 | |
| Effects of Sodium Bicarbonate Supplementation on Intermittent and Intense Task Sodium bicarbonate, Calcium carbonate - Sodium Bicarbonate, Alkalosis, Metabolic | Not applicable | Unknown | University of Nove de Julho | 12 | 2019-10-20 | 2019-10-17 |
| Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in isolated plasma., In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in whole blood, Biomolecular analysis of plasma proteins. - Sepsis, Septic Shock | Unknown | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 90 | 2019-06-03 | 2019-06-04 | |
| Evaluation of Respiratory Function in Fibromyalgia Fibromyalgia, Respiratory Alkalosis and Metabolic Acidosis | Completed | Uppsala University | 90 | 2018-06-28 | 2022-03-21 | |
| The Effect of Bicarbonate Profiling in Dialysis Fluid on Phosphate Removal During Hemodialysis and Blood pH Group 1: B) Dbic 35 -30 mmol/L C) Dbic 30- 35 mmol/L, Group 2: C) Dbic 30 -35 mmol/L B) Dbic 35- 30 mmol/L - Phosphorus Metabolism Disorders, Acid-Base Balance Disorder | Not applicable | Completed | Medical University of Warsaw | 20 | 2018-05-21 | 2023-05-23 |
| Cerebrospinal Acid-base in Pregnant and Non-pregnant Fertile Women Acid - Base characterization - Acid-Base Imbalance, Respiratory Alkalosis | Unknown | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 40 | 2018-04-13 | 2018-04-17 | |
| Non Carbonic Buffer Power of Critical Ill Patients With Sepsis In vitro determination of non-carbonic buffer power, Classic description of acid-base status - Acid-Base Imbalance, Respiratory Acidosis | Completed | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 36 | 2018-03-07 | 2019-04-25 | |
| Comparison of Transcutaneous Vs End-tidal CO2 Pressure Measurements in Hyperventilation Syndrome Diagnosis Simultaneous Transcutaneous and End-tidal CO2 measurements - Hyperventilation Syndrome, Hypocapnia | Not applicable | Completed | University Hospital, Rouen | 14 | 2017-12-21 | 2020-06-29 |
| Is Venous to Arterial Conversion (v-TAC) of Blood Gas Reliable in Critical Ill Patients in the ICU? venous to arterial conversion (v-TAC) - Respiratory Insufficiency, Metabolic Disease | Unknown | Aalborg University | 50 | 2017-10-09 | 2017-10-13 | |
| Effect of the Diet on Urinary Excretion of Alpha-ketoglutarate Meat and vegetable diet - Acid Base Disorder | Not applicable | Completed | Michel Burnier | 32 | 2013-06-01 | 2019-07-31 |
| Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m Sodium Citrate Dihydrate - Alkalosis | Phase 3 | Completed | Brock University | 10 | 2012-09-01 | 2014-07-24 |
| Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures Carbogen, Placebo - Febrile Seizure | Phase 2 / Phase 3 | Terminated | Charite University, Berlin, Germany | 96 | 2012-08-01 | 2018-01-26 |
| Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation. Acetazolamide, Placebo - Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome | Phase 3 | Completed | Hospital Son Llatzer | 140 | 2011-11-01 | 2015-03-17 |
| Respiratory Physiology in Children With Febrile Seizures. Febrile Illness Acute, Seizures, Febrile | Completed | Charite University, Berlin, Germany | 100 | 2011-07-01 | 2026-01-02 | |
| Normalizing CO2 in Chronic Hyperventilation by a Novel Breathing Mask: A Pilot Study Partial Rebreathing Mask - Hyperventilation, Chronic Idiopathic Hyperventilation | Not applicable | Completed | University of Aarhus | 6 | 2011-02-01 | 2016-05-19 |
| Acetazolamide Facilitates Ventilator Weaning acetazolamide, Saline - Ventilator Weaning, Alkalosis, Metabolic | Not applicable | Unknown | Asan Medical Center | 150 | 2010-05-01 | 2010-05-27 |
| Clinical Evidence of pH Dependent ß2 Adrenergic Transport Mechanisms in the Airway quiet breathing, Hypocapnic Hyperventilation, Hypercapnic Hyperventilation - Healthy Volunteers | Not applicable | Completed | University of Miami | 10 | 2010-01-01 | 2016-05-27 |
| Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis Acetazolamide, Placebo - Respiratory Insufficiency, Alkalosis | Phase 4 | Completed | University of Oslo School of Pharmacy | 70 | 2002-01-01 | 2014-01-20 |
Alkalosis, Respiratory (8) · Acidosis (5) · Acid-Base Imbalance (3) · Acidosis, Respiratory (3) · Hyperventilation (2) · Respiratory Aspiration (2) · Respiratory Insufficiency (2) · Seizures, Febrile (2) · Sepsis (2) · Abdomen, Acute (1) · Critical Illness (1) · Fatigue (1) · Fibromyalgia (1) · Hypocapnia (1)
Nutritional and Metabolic Diseases (18) · Metabolic Diseases (17) · Acid-Base Imbalance (15) · Respiration Disorders (11) · Respiratory Tract Diseases (11) · Pathological Conditions, Signs and Symptoms (9) · Hyperventilation (6) · Signs and Symptoms (6) · Nervous System Diseases (4) · Pathologic Processes (4) · Respiratory Insufficiency (4) · Acidosis (3) · Neurologic Manifestations (3) · Disease Attributes (2)
Acetazolamide (3) · Calcium Carbonate (1) · Meat (1) · Oxygen (1) · Sodium Bicarbonate (1) · Sodium Chloride (1) · Sodium Citrate (1) · carbogen (1)
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (3) · Charite University, Berlin, Germany (2) · Aalborg University (1) · Acıbadem Atunizade Hospital (1) · Asan Medical Center (1) · Brock University (1) · Hospital Son Llatzer (1) · Medical University of Warsaw (1) · Michel Burnier (1) · University Hospital, Rouen (1) · University of Aarhus (1) · University of Miami (1) · University of Nove de Julho (1) · University of Oslo School of Pharmacy (1) · Uppsala University (1)
Italy (3) · Denmark (2) · Germany (2) · Brazil (1) · Canada (1) · Czechia (1) · France (1) · Norway (1) · Poland (1) · South Korea (1) · Spain (1) · Sweden (1) · Switzerland (1) · Turkey (Türkiye) (1) · United States (1)
Thomas Langer, MD (3) · Antonio Pesenti, MD (2) · Giacomo Grasselli, MD (2) · Antonio M Pesenti, MD (1) · Chae-Man Lim, professor (1) · Edoardo Calderini, MD (1) · Frantisek Duska, MD (1) · Giorgio Giudici, MD (1) · Magnus Peterson, MD PhD (1) · Mariateresa Ambrosini, MD (1) · Markus Schuelke, MD (1) · Matthias Salathe (1) · Michel Burnier, professor (1)
PMID 23578004, PMID 24944546, PMID 25889594, PMID 28286047, PMID 36096944, PMID 40706939, PMID 41433250
R01HL060644 (1)