10 completed, 3 unknown, 2 not yet recruiting, 2 recruiting. 9 Not applicable, 4 Phase 3, 3 Phase 4, 2 Phase 2, 1 Early Phase 1.
Follow Bicarbonates: new trials by email Literature Review of Bicarbonates trials Research Report on Bicarbonates
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients Sodium bicarbonate, Tris-hydroxymethyl Aminomethane - Metabolic Acidosis | Phase 4 | Recruiting | Mayo Clinic | 250 | 2026-09-14 | 2026-09-21 |
| Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems 0.45% SnF HW with NaF (1450 F), 67% Bicarbonate with NaF (1400 F), Colgate Cavity Protection Toothpaste - Plaque, Dental Plaque | Phase 3 | Recruiting | Colgate Palmolive | 120 | 2026-07-20 | 2026-09-25 |
| Bicarbonate Addition to Lidocaine-Epinephrine in Surgery Under WALANT Ambulatory surgery under Lidocaine with epinephrine alone, Ambulatory surgery under lidocaine with epinephrine plus bicarbonate - Anesthesia, Local, Hand Surgery | Phase 4 | Not yet recruiting | Centre Hospitalier Universitaire de Nīmes | 150 | 2026-02-01 | 2026-01-15 |
| Clinical Investigation of Bleeding Reduction Efficacy on Toothpaste Containing 1.05% Chitosan Toothpaste containing 1.05% Chitosan, Silica-based NaF Toothpaste, Toothpaste with 67% bicarbonate - Bleeding Gum, Gingivitis | Not applicable | Completed | Colgate Palmolive | 134 | 2025-04-29 | 2025-08-15 |
| Dial-Bicarb Trial: Effects of a Lower vs. Higher Concentration of Dialysate Bicarbonate Bicarbonate - Renal Failure, Hemodialysis | Not applicable | Not yet recruiting | McMaster University | 14000 | 2025-04-01 | 2025-03-20 |
| The Effects of Ankaferd Blood Stopper Ankaferd Blood Stopper, Bicarbonate - Colon Cancer, Oral Mucositis | Not applicable | Unknown | Uludag University | 66 | 2021-06-01 | 2023-06-01 |
| Paraffin Oil or Coconut Oil in Acute Aluminum Phosphide Poisoning gastric lavage with paraffin oil and bicarbonate, gastric lavage with coconut oil and bicarbonate, standard treatment - Aluminum Phosphide Poisoning | Early Phase 1 | Completed | Tanta University | 89 | 2021-01-01 | 2022-06-08 |
| Effect of Xylitol-Containing Chewing Gum With/Without Bicarbonate Versus Paraffin Pellet on Salivary pH Xylitol, xylitol with bicarbonate, paraffin - Dental Caries | Not applicable | Unknown | Cairo University | 36 | 2017-03-03 | 2017-02-24 |
| Alkalinization by Urologists & Nephrologists Alkali - Metabolic Acidosis, Nephrolithiasis | Phase 4 | Completed | Jean-Philippe Bertocchio | 156 | 2017-02-01 | 2020-07-14 |
| Magnesium-Based Trigger Point Injections for Relief of Chronic Myofascial Pelvic Pain Magnesium-Based Injection Formulation, Lidocaine-Only Injection Formulation, lidocaine - Pelvic Pain | Phase 3 | Terminated | Queen's University | 38 | 2016-04-01 | 2023-03-31 |
| Pathways to Improving Functional Capacity in Older Patients With Chronic Kidney Disease and Cardiovascular Disease Fish Oil and Bicarbonate, Fish Oil and Bicarbonate Placebo, Fish Oil Placebo and Bicarbonate - Chronic Kidney Disease, Cardiovascular Disease | Not applicable | Withdrawn | Wake Forest University Health Sciences | 2016-01-01 | 2017-11-07 | |
| Correction of Metabolic Acidosis in End Stage Renal Disease (ESRD) Bicarbonate - Metabolic Acidosis | Phase 3 | Unknown | Azienda Sanitaria ASL Avellino 2 | 728 | 2014-07-01 | 2014-09-19 |
| Will Adjusting the pH of Lidocaine Reduce the Pain During Injection of Local Anaesthetic? Lidocaine injection with bicarbonate, lidocaine injection - Needlestick Injuries | Not applicable | Completed | Norwegian University of Science and Technology | 32 | 2014-02-01 | 2015-05-27 |
| Bicarbonates Versus Saline for Contrast Induced Acute Kidney Injury Prevention in Intensive Care Unit bicarbonates, saline - Contrast Induced Acute Kidney Injury | Phase 3 | Completed | University Hospital, Caen | 300 | 2012-02-01 | 2026-02-17 |
| Prevention of Acute Kidney Injury in Cardiac Surgery Patients 0.9% Sodium Chloride (Placebo), Sodium Bicarbonate - Kidney Injury | Phase 2 | Completed | Community Medical Center, Scranton, PA | 92 | 2009-01-01 | 2014-04-15 |
| Prevention of Contrast Induced Nephropathy (NIC) by Intravenous Versus Oral Rehydration Intravenous hydration with bicarbonate, Oral hydration with Sodium solution - KIDNEY FAILURE, ACUTE | Not applicable | Completed | Clinica Universidad de Navarra, Universidad de Navarra | 167 | 2008-09-01 | 2012-06-08 |
| Use of Bicarbonate to Reduce the Incidence of Acute Renal Failure After Cardiac Surgery Sodium bicarbonate, Normal saline, Bicarbonate - Kidney Failure, Acute, Renal Replacement Therapy | Phase 2 | Completed | Wake Forest University Health Sciences | 123 | 2006-05-01 | 2018-10-16 |
| Does Bicarbonate in Addition to Theophylline Reduce CIN? Hydration with bicarbonate in addition to theophylline, Hydration with sodium chloride in addition to theophylline - Radiographic Contrast Agent Nephropathy | Not applicable | Completed | Technical University of Munich | 152 | 2005-12-01 | 2016-01-01 |
| Randomized Study of Pancrelipase With Bicarbonate (PANCRECARB) Capsules in Reducing Steatorrhea in Patients With Cystic Fibrosis pancrelipase with bicarbonate - Cystic Fibrosis | Not applicable | Completed | National Center for Research Resources (NCRR) | 24 | 1999-07-01 | 2005-06-24 |
Acidosis (3) · Acute Kidney Injury (3) · Gingivitis (2) · Renal Insufficiency (2) · Body Weight (1) · Cardiovascular Diseases (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Cystic Fibrosis (1) · Dental Caries (1) · Dental Plaque (1) · Genetic Diseases, Inborn (1) · Gingival Hemorrhage (1) · Needlestick Injuries (1) · Nephrolithiasis (1)
Colgate Palmolive (2) · Wake Forest University Health Sciences (2) · Azienda Sanitaria ASL Avellino 2 (1) · Cairo University (1) · Centre Hospitalier Universitaire de Nīmes (1) · Clinica Universidad de Navarra, Universidad de Navarra (1) · Community Medical Center, Scranton, PA (1) · Jean-Philippe Bertocchio (1) · Mayo Clinic (1) · McMaster University (1) · National Center for Research Resources (NCRR) (1) · Norwegian University of Science and Technology (1) · Queen's University (1) · Tanta University (1) · Technical University of Munich (1)
United States (4) · France (3) · Egypt (2) · Italy (2) · Canada (1) · China (1) · Norway (1) · Spain (1) · Turkey (Türkiye) (1)
Amit Garg, MD (1) · Biagio Di Iorio, MD, PhD (1) · Judith L Kristeller, PharmD (1) · Julie Beaume, MD (1) · Killian Robinson, MD (1) · Luigi Montensani, DDS (1) · Mary Sue Brady (1) · Michael V. Rocco, MD (1) · Misty A. Radosevich, MD (1) · Romy Nitsch, MD, MHSc (1) · Vilhjalmur Finsen, Prof md (1) · Wolfgang Huber, M.D. (1)
PMID 16041502, PMID 18304416, PMID 23553549, PMID 24854326, PMID 25596649, PMID 25991379, PMID 27770799, PMID 31286226, PMID 31598912, PMID 31631858, PMID 32065601, PMID 34564842, PMID 35339694, PMID 37289263, PMID 9659518