16 completed, 5 recruiting, 3 terminated, 2 unknown. 28 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 28 | Completed 16, Recruiting 5, Terminated 3, Unknown 2, Not yet recruiting 1, Withdrawn 1 |
Follow Acid-Base Imbalance: new trials by email Literature Review of Acid-Base Imbalance trials Research Report on Acid-Base Imbalance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients Sodium bicarbonate, Tris-hydroxymethyl Aminomethane - Metabolic Acidosis | Phase 4 | Recruiting | Mayo Clinic | 250 | 2026-09-14 | 2026-09-21 |
| Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury Sodium Bicarbonate 8.4% Solution for Injection, Balanced crystalloid solution - Acute Kidney Injury, Metabolic Acidosis | Phase 4 | Recruiting | Universität Münster | 660 | 2026-05-07 | 2026-09-04 |
| Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure Ketone Monoester (KE) - Acute Heart Failure (AHF), Cardiogenic Shock | Phase 4 | Recruiting | Institute for Clinical and Experimental Medicine | 12 | 2026-04-04 | 2026-04-14 |
| Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration? Dapagliflozin (DAPA), Pioglitazone 45 mg, Placebo - Type 1 Diabetes | Phase 4 | Not yet recruiting | Dasman Diabetes Institute | 60 | 2025-09-15 | 2025-08-29 |
| Ephedrine Versus Norepinephrine and Fetal Acid-Base Status During Cesarean Delivery Under Spinal Anesthesia Norepinephrine, Ephedrine - Cesarean Delivery Affecting Newborn, Acidosis | Phase 4 | Completed | mehmet özkılıç | 155 | 2025-09-01 | 2026-10-08 |
| Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity Continuous Glucose Monitoring, Insulin - Ketosis Prone Diabetes | Phase 4 | Recruiting | Emory University | 12 | 2025-01-23 | 2026-06-15 |
| 0.9% Saline Versus Balanced Solutions in Severe Diabetic Ketoacidosis Sodium chloride 0.9% (SC), Ringer lactate (RL) - Metabolic Ketoacidosis, Ketoacidemia | Phase 4 | Completed | Tunis University | 92 | 2022-11-01 | 2024-04-12 |
| Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency SGLT2 inhibitor, Biosense Breath Ketone Analyzer - Diabetes Mellitus, Type 1 | Phase 4 | Completed | Washington University School of Medicine | 21 | 2022-10-14 | 2025-02-21 |
| Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients Sodium bicarbonate, Placebo - Metabolic Acidosis, Kidney Transplant; Complications | Phase 4 | Recruiting | University of Colorado, Denver | 120 | 2021-12-01 | 2025-05-29 |
| Optimal Dosage of Acetazolamide for OSA Treatment Acetazolamide, Placebo - Obstructive Sleep Apnea | Phase 4 | Completed | University Hospital, Antwerp | 91 | 2021-04-20 | 2025-09-24 |
| Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management Early Glargine, Late Glargine, IV insulin infusion - Diabetic Ketoacidosis, Type 1 Diabetes | Phase 4 | Terminated | The Cleveland Clinic | 39 | 2020-10-01 | 2022-09-21 |
| Metformin in Diabetic Patients Undergoing Coronary Angiography Metformin - Diabetes Mellitus, Coronary Artery Disease | Phase 4 | Unknown | Humanitas Hospital, Italy | 150 | 2020-01-15 | 2022-04-12 |
| High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy Low bicarbonate solution (22 mmol/L), High Bicarbonate solution (32 mmol/L) - Metabolic Acidosis, Acute Kidney Injury | Phase 4 | Withdrawn | Mayo Clinic | 2019-05-01 | 2021-04-28 | |
| Double Blinded Randomized Control Trial of Types of IVF in Children With DKA Normal saline, Lactated Ringers - Diabetic Ketoacidosis | Phase 4 | Terminated | State University of New York at Buffalo | 53 | 2018-09-01 | 2024-08-06 |
| Metabolic Responses of Dapagliflozin vs Sitagliptin in T2DM Patients Inadequately Controlled With Insulin Therapy Dapagliflozin 10 mg, Sitagliptin 100mg - Type 2 Diabetes, Ketonemia | Phase 4 | Completed | The University of Hong Kong | 60 | 2017-08-16 | 2021-04-29 |
| Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes Glargine, Continuous Glucose Monitor (Abbott FreeStyle Libre Pro) - Diabetic Ketoacidosis, Type 1 Diabetes Mellitus | Phase 4 | Completed | University of Colorado, Denver | 61 | 2017-07-21 | 2022-05-10 |
| Preserve-Transplant Study Nephrotrans, Placebo - Acidosis, Renal Insufficiency | Phase 4 | Completed | University of Zurich | 240 | 2017-06-12 | 2022-04-22 |
| Dosage Reduction and Acute Glycemic Complications in People With Type 2 Diabetes Who Fast During Ramadan Metformin and Glimepiride (Low Dosage), Metformin and Vildagliptin (Low Dosage), Metformin and Insulin Glargine U100 (Low Dosage) - Diabetes Mellitus, Type 2 | Phase 4 | Completed | University of Jordan | 687 | 2017-02-14 | 2020-02-11 |
| Alkalinization by Urologists & Nephrologists Alkali - Metabolic Acidosis, Nephrolithiasis | Phase 4 | Completed | Jean-Philippe Bertocchio | 156 | 2017-02-01 | 2020-07-14 |
| Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Vitamin B1-ratiopharm, Placebo - Heart Failure, Acidosis, Lactic | Phase 4 | Completed | Medical University of Vienna | 30 | 2012-02-01 | 2021-02-26 |
Showing 20 of 28. Sign in to see all of them.
Acidosis (10) · Diabetic Ketoacidosis (7) · Acidosis, Lactic (5) · Diabetes Mellitus, Type 1 (5) · Ketosis (5) · Diabetes Mellitus, Type 2 (4) · Acute Kidney Injury (3) · Critical Illness (2) · Heart Failure (2) · Hypoglycemia (2) · Achlorhydria (1) · Acquired Immunodeficiency Syndrome (1) · Alkalosis (1) · Body Weight (1) · Coronary Artery Disease (1)
Metabolic Diseases (28) · Nutritional and Metabolic Diseases (28) · Acidosis (16) · Endocrine System Diseases (11) · Diabetes Mellitus (10) · Glucose Metabolism Disorders (8) · Diabetes Complications (7) · Pathological Conditions, Signs and Symptoms (7) · Urogenital Diseases (7) · Female Urogenital Diseases (6) · Female Urogenital Diseases and Pregnancy Complications (6) · Immune System Diseases (6) · Ketosis (6) · Kidney Diseases (6)
Insulin (3) · Insulin Glargine (3) · Ringer's Lactate (3) · Sodium Bicarbonate (3) · Sodium Chloride (3) · dapagliflozin (3) · Acetazolamide (2) · Bicarbonates (2) · Citric Acid (2) · Metformin (2) · Alkalies (1) · Ammonium Chloride (1) · Carnitine (1) · Continuous Glucose Monitoring (1) · Ephedrine (1)
Emory University (2) · Mayo Clinic (2) · University of Colorado, Denver (2) · Asan Medical Center (1) · Austin Health (1) · Dasman Diabetes Institute (1) · Humanitas Hospital, Italy (1) · IRCCS Policlinico S. Donato (1) · Institute for Clinical and Experimental Medicine (1) · Jean-Philippe Bertocchio (1) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (1) · Medical University of Vienna (1) · Queen's University (1) · State University of New York at Buffalo (1) · The Cleveland Clinic (1)
United States (11) · Italy (2) · Australia (1) · Austria (1) · Belgium (1) · Canada (1) · Czechia (1) · France (1) · Germany (1) · Hong Kong (1) · Jordan (1) · Kuwait (1) · Norway (1) · Qatar (1) · Saudi Arabia (1)
Ahlem Trifi (1) · Alexander Zarbock, MD (1) · Amanda B Hassinger, MD, MS (1) · Ayman A. Zayed, MD (1) · Fahd Al-Mulla, MD, PhD (1) · Guillermo Umpierrez, MD (1) · Han Chu Lee, M.D (1) · Janet B McGill, MD (1) · Jessica Kendrick, MD MPH (1) · Julie Beaume, MD (1) · Karen E Hansen, MD (1) · Kathryn Tan, MD (1) · Kianoush B Kashani (1) · Marco Ranucci, M.D. (1)
PMID 19366972, PMID 19846545, PMID 20332738, PMID 20578215, PMID 21347742, PMID 21705897, PMID 23073953, PMID 23578004, PMID 26066773, PMID 30001705, PMID 34305809, PMID 34564842, PMID 36708734, PMID 36747244, PMID 39607014, PMID 39974120, PMID 40234173, PMID 40260699, PMID 41953463
2008 (1), 2025 (1), R01DK130255 (1)