23 completed, 2 not yet recruiting, 2 recruiting, 2 withdrawn. 16 Not applicable, 5 Early Phase 1, 5 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Completed 14, Not yet recruiting 2 |
| Early Phase 1 | 5 | Completed 4, Withdrawn 1 |
| Phase 1 | 5 | Completed 5 |
| Phase 2 | 1 | Withdrawn 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow Vasoconstriction: new trials by email Literature Review of Vasoconstriction trials Research Report on Vasoconstriction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline Placement Immersive Virtual Reality, Peripherally Inserted Central Catheter (PICC), Mepivacaine 2% Injection - Vasoconstriction, Biomarkers | Not applicable | Not yet recruiting | diana garcia | 202 | 2027-01-15 | 2026-07-10 |
| Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Prone position - Right Ventricular Function, Prone Position | Not applicable | Not yet recruiting | Sahlgrenska University Hospital | 70 | 2026-10-01 | 2026-10-23 |
| Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate - Vasoconstriction, Vasodilation | Phase 4 | Recruiting | University of Alberta | 30 | 2023-10-31 | 2026-01-08 |
| Sex Differences in Sympathetic Vascular Reactivity at High Altitude Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 17 | 2022-07-28 | 2024-09-19 |
| Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU Hemodynamic measurements during reduction in Norepinephrine and fluid boli. - Septic Shock, Hemodynamic Instability | Recruiting | Copenhagen University Hospital, Hvidovre | 45 | 2022-03-08 | 2025-03-07 | |
| The Impact of Carbon Monoxide and Altitude on Vascular Function Carbon monoxide rebreathe, Sodium Nitroprusside, Phenylephrine Hydrochloride - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 19 | 2021-06-10 | 2022-05-25 |
| Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity Cold Pressor Test - Obesity, Healthy | Early Phase 1 | Completed | University of Missouri-Columbia | 73 | 2020-12-09 | 2026-07-28 |
| Curcumin and Exercise in Chronic Kidney Disease Curcumin, Placebo - Chronic Kidney Diseases, Blood Pressure | Phase 2 | Withdrawn | University of Iowa | 2020-11-15 | 2023-02-21 | |
| Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction Insulin - Vasoconstriction, Healthy | Early Phase 1 | Completed | University of Missouri-Columbia | 28 | 2020-08-06 | 2023-02-17 |
| Prevention of Maternal Hypotension During Cesarean Section With Norepinephrine Infusion. norepinephrine infusion and colloid preloading (NOR-COL), norepinephrine infusion and crystalloid co-loading (NOR-CRYST) - Hypotension, Obstetric Anesthesia Problems | Not applicable | Completed | Aretaieion University Hospital | 100 | 2020-05-26 | 2021-06-15 |
| Colloid Co-hydration and Vasoconstrictor Infusion for Prevention of Hypotension During Cesarean Section phenylephrine infusion, norepinephrine infusion, placebo infusion - Hypotension Symptomatic, Vasoconstriction | Not applicable | Completed | Aretaieion University Hospital | 120 | 2020-05-23 | 2021-06-15 |
| A Pilot Study to Assess the Feasibility and Tolerability of the AccuFlow Perfusion Sensor for Intrapartum Hemorrhage AccuFlow sensor, Survey - Hemorrhage, Postpartum, Hemorrhage | Not applicable | Completed | Megan Lord | 25 | 2020-05-20 | 2021-07-13 |
| Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia. Phenylephrine Hydrochloride, Cold Pressor Test, Isocapnic Acute Hypoxia - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 14 | 2019-08-04 | 2022-10-31 |
| Evidence of Spreading Vasoconstriction in Human Gingiva Epinephrine - Vasoconstriction, Oral Soft Tissue Conditions | Not applicable | Completed | Semmelweis University | 29 | 2019-05-01 | 2020-07-02 |
| Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training Handgrip Exercise Training, Acetylcholine, Adenosine Triphosphate - Vasoconstriction, Vasodilation | Early Phase 1 | Withdrawn | Colorado State University | 2019-04-16 | 2021-08-02 | |
| Prevention of Hypotension During Cesarean Section phenylephrine infusion, norepinephrine infusion - Hypotension Symptomatic, Obstetric Anesthesia Problems | Not applicable | Completed | Aretaieion University Hospital | 82 | 2019-02-16 | 2020-05-26 |
| Microcirculatory Vasomotor Changes in Type 2 Diabetes With Peripheral Neuropathy "Rest", "Exercise", "Foot lowering" - Diabetic Neuropathy Peripheral, Small Vessel Disease of Diabetes Mellitus | Not applicable | Completed | University of Avignon | 108 | 2019-02-04 | 2020-11-13 |
| Vascular Function Improvements After Chronic Passive Stretching Passive stretching (PS) training - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Milan | 39 | 2019-01-07 | 2020-02-17 |
| Evaluation of the Vasoconstriction Properties of MC2-01 Cream MC2-01 Cream, Clobetasol Propionate 0.05% Lotion, Betamethasone Dipropionate 0.05% Cream - Vasoconstriction | Phase 1 | Completed | MC2 Therapeutics | 36 | 2018-11-05 | 2020-01-09 |
| Local Antioxidant Therapy Vasoconstriction Effects in Different Races Control (Norepinephrine), Norepinephrine + Ascorbic Acid, Norepinephrine + L-NAME - Cardiovascular Diseases, Cardiovascular Risk Factor | Phase 1 | Completed | The University of Texas at Arlington | 22 | 2018-10-15 | 2024-06-11 |
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Aneurysm (11) · Cardiovascular Diseases (4) · Hypotension (2) · Inflammation (2) · Motor Activity (2) · Anxiety Disorders (1) · Blood Coagulation Disorders (1) · Cardiac Output, High (1) · Cardiac Output, Low (1) · Diabetic Angiopathies (1) · Heart Failure (1) · Hemorrhage (1) · Hyperemia (1) · Insulin Resistance (1) · Obesity (1)
Cardiovascular Diseases (17) · Vascular Diseases (16) · Pathological Conditions, Signs and Symptoms (8) · Pathologic Processes (5) · Respiratory Tract Diseases (3) · Signs and Symptoms (3) · Behavior (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Heart Diseases (2) · Lung Diseases (2) · Nutritional and Metabolic Diseases (2) · Urogenital Diseases (2) · Apnea (1) · Body Weight (1) · Chronic Disease (1)
Phenylephrine (6) · Nitroprusside (5) · Norepinephrine (4) · NG-Nitroarginine Methyl Ester (3) · Allopurinol (2) · Bosentan (2) · Phentolamine (2) · Propranolol (2) · acetovanillone (2) · Acetylcholine (1) · Adenosine Triphosphate (1) · Arginine (1) · Ascorbic Acid (1) · Atropine (1) · BQ 788 (1)
The University of Texas at Arlington (4) · University of Alberta (4) · Aretaieion University Hospital (3) · University of Missouri-Columbia (3) · Fudan University (2) · Colorado State University (1) · Copenhagen University Hospital, Hvidovre (1) · Insel Gruppe AG, University Hospital Bern (1) · MC2 Therapeutics (1) · Megan Lord (1) · Sahlgrenska University Hospital (1) · Semmelweis University (1) · University of Avignon (1) · University of Edinburgh (1) · University of Iowa (1)
United States (10) · Canada (4) · Greece (3) · China (2) · France (2) · Denmark (1) · Hungary (1) · Italy (1) · Spain (1) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Sean van Diepen, MD, MSc (4) · Craig Steinback, PhD (3) · Emmanouil Stamatakis, PhD (2) · Kassiani Theodoraki, PhD, DESA (2) · Catherine Abee, CRT (1) · Christoph C Ganter, M.D. (1) · Craig D Steinback, PhD (1) · Dimitrios Valsamidis, MD (1) · Dimitrios Valsamidis, PhD (1) · Eric Benamo, MD (1) · Frank Dinenno, PhD (1) · Haidong Kan (1) · Jacqueline K Limberg, Ph.D. (1)
PMID 31023432, PMID 33148235, PMID 34111245, PMID 36309727
2025 (1), K99HL130339 (1), R00HL130339 (1)