University of Iowa: Clinical Trials

306 completed, 61 recruiting, 47 terminated, 26 active not recruiting. 228 Not applicable, 69 Phase 2, 34 Phase 3, 33 Phase 4, 30 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	228	Completed 152, Recruiting 26, Terminated 18, Withdrawn 10, Active not recruiting 8, Not yet recruiting 7, Unknown 5, Enrolling by invitation 2
Phase 2	69	Completed 37, Terminated 15, Recruiting 8, Active not recruiting 4, Withdrawn 4, Unknown 1
Phase 3	34	Completed 19, Recruiting 5, Active not recruiting 4, Terminated 4, Unknown 1, Withdrawn 1
Phase 4	33	Completed 22, Terminated 3, Withdrawn 3, Active not recruiting 2, Enrolling by invitation 1, Recruiting 1, Unknown 1
Phase 1	30	Completed 15, Terminated 7, Withdrawn 4, Active not recruiting 3, Recruiting 1
Early Phase 1	9	Completed 4, Recruiting 4, Active not recruiting 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Dimensional Changes: Randomized Clinical Trial Gum Graft Placed on Denuded Bone, Gum Graft Placed on Split Thickness Periosteal Bed Preparation - Gingival Recession	Not applicable	Not yet recruiting	University of Iowa	50	2028-08-01	2026-09-09
Adapting Changing Talk: Online (CHATO) to CHATO-Inclusive CHATO-I - Dementia	Not applicable	Not yet recruiting	University of Kansas Medical Center	1200	2027-01-01	2026-06-02
Accelerated iTBS for Depression and Suicidality Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT) - Major Depressive Disorder, Suicide	Not applicable	Not yet recruiting	University of Iowa	50	2026-12-01	2025-05-20
Evaluation of an Online, On Demand Multimodal Wellness Program to Reduce Fatigue and Improve Quality of Life in Progressive Multiple Sclerosis. Online wellness course and online exercise platform, Usual Care Group - Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive Multiple Sclerosis (SPMS)	Not applicable	Not yet recruiting	University of Iowa	118	2026-11-15	2026-09-28
Dynamics of Wound Healing in Patients With Obesity Collagen Plug (standard of care), Platelet-Rich Fibrin Clot - Wound Healing	Not applicable	Recruiting	University of Iowa	104	2026-10-13	2026-10-22
SAIL-MEVO: Endovascular Treatment Versus Best Medical Therapy for Distal Vessel Occlusions best medical therapy, Endovascular Treatment - Medium Vessel Occlusion Stroke (MeVO), Stroke Acute	Not applicable	Not yet recruiting	Hospital Universitari Vall d'Hebron Research Institute	420	2026-10-01	2026-09-28
Use of Allied-health Professionals to Improve Treatment of Disease Research Pharmacist - Preeclampsia	Not applicable	Not yet recruiting	University of Iowa	200	2026-10-01	2026-06-04
Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis Terazosine, Placebo - Amyotrophic Lateral Sclerosis, Adenosine Triphosphate Activities	Early Phase 1	Recruiting	University of Iowa	20	2026-08-12	2026-09-09
Perinatal Autism Genetics and Epigenetics Study Change in child's DNA methylation, Perinatal stress, Early social experience - Autism Disorders and Maternal Stress, Development Delay		Recruiting	University of Iowa	7200	2026-05-12	2026-08-03
Cohort Study of PPP Injections for Athletes With Muscle Injury Platelet Poor Plasma (PPP) Injection - Lower Extremity Injury	Not applicable	Not yet recruiting	University of Colorado, Denver	90	2026-05-01	2026-05-06
Aerodynamic Measurements in the Pediatric Population Complete airflow interruption, Incomplete airflow interruption, Airflow redirection - Normal Voice	Not applicable	Recruiting	University of Wisconsin, Madison	365	2025-12-22	2026-05-15
The Effects of Footplate Stiffness on Foot Loading Within Carbon Fiber Custom Dynamic Orthoses Carbon Fiber Custom Dynamic Orthosis, Carbon Fiber Footplate - Trauma Injury	Not applicable	Completed	Jason Wilken	17	2025-12-13	2026-10-19
Genetic Risk Factor for Heat Stroke Heat Challenge - Carrier State, Heat Stroke		Recruiting	University of Iowa	200	2025-11-19	2026-04-27
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity Mitoquinone mesylate (MitoQ), Placebo - Adverse Childhood Experience, Endothelial Function (FMD)	Not applicable	Recruiting	University of Iowa	300	2025-10-13	2025-11-24
Harnessing Communication Preferences PrefFCT, NonPrefFCT - Intellectual Disability, Autism Spectrum Disorder	Not applicable	Recruiting	Joel E. Ringdahl	60	2025-08-15	2025-12-12
Pharmacist Intervention to Improve Smoking Cessation Pharmacist Intervention - Smoking Cessation	Not applicable	Completed	University of Iowa	80	2025-08-11	2026-08-31
Paediatric Post-TB Pulmonary Rehab Study Pulmonary Rehabilitation - Tuberculosis in Children, Chronic Lung Disease	Not applicable	Recruiting	University of Iowa	40	2025-07-29	2025-08-11
Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study Atogepant 60 mg, Propranolol 160 mg, Topiramate 100 mg - Migraine	Phase 4	Recruiting	Mayo Clinic	1335	2025-07-09	2026-10-19
Effect of Custom Dynamic Orthoses on Forefoot Loading Visual Feedback - Lower Extremity Injuries	Not applicable	Recruiting	University of Iowa	60	2025-06-18	2026-10-19
Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial Psilocybin, Ketamine - Alcohol Use Disorder, Alcohol Dependence	Phase 2	Recruiting	University of Iowa	80	2025-06-12	2025-11-28

Showing 20 of 496. Sign in to see all of them.

Conditions studied

Depression (13)  ·  Osteoarthritis, Knee (12)  ·  Neoplasms (10)  ·  Obesity (10)  ·  Sedentary Behavior (10)  ·  Motor Activity (9)  ·  Charcot-Marie-Tooth Disease (8)  ·  Hypertension (8)  ·  Anxiety Disorders (7)  ·  Breast Neoplasms (7)  ·  Heart Failure (7)  ·  Pain (7)  ·  Sarcoma (7)  ·  Stroke (7)  ·  Cardiovascular Diseases (6)

Interventions

Standard of Care (7)  ·  Transcranial Direct Current Stimulation (7)  ·  Exercise (5)  ·  Gemcitabine (5)  ·  Saline Solution (5)  ·  Sodium Chloride (5)  ·  Ascorbic Acid (4)  ·  Blood Specimen Collection (4)  ·  Dexamethasone (4)  ·  Educational Status (4)  ·  Motivational Interviewing (4)  ·  Acceptance and Commitment Therapy (3)  ·  Aspirin (3)  ·  Celecoxib (3)  ·  Cochlear Implants (3)

Countries

United States (452)  ·  Canada (21)  ·  United Kingdom (14)  ·  Australia (8)  ·  Italy (6)  ·  Germany (5)  ·  Brazil (4)  ·  Czechia (3)  ·  New Zealand (3)  ·  Austria (2)  ·  India (2)  ·  Israel (2)  ·  Kenya (2)  ·  Netherlands (2)  ·  Sweden (2)

Top investigators

Jason M Wilken, PT, PhD (9)  ·  John M. Buatti, M.D. (4)  ·  Neil A Segal, MD, MS (4)  ·  Barry L. Carter, PharmD (3)  ·  Corinne Peek-Asa, PhD (3)  ·  Geraldine Jacobson, MD MPH (3)  ·  John Rieth, MD (3)  ·  Kenichi Ueda, MD (3)  ·  Lucas Carr, PhD (3)  ·  Michael E Shy, MD (3)  ·  Mohammed Milhem, MD (3)  ·  Nicholas Johnson, MD (3)  ·  Peggy C Nopoulos, MD (3)  ·  Susan K Lutgendorf, PhD (3)

Results publications

PMID 18477783, PMID 28437190, PMID 35224730, PMID 41944009, PMID 10411196, PMID 10673515, PMID 10930491, PMID 11382253, PMID 12080313, PMID 12235608, PMID 12671856, PMID 14969373, PMID 1532109, PMID 15680560, PMID 15930233, PMID 16563165, PMID 17138373, PMID 17414236, PMID 18312102, PMID 18328050, PMID 18401223, PMID 18482509, PMID 18808544, PMID 18843618, PMID 19084178, PMID 19117316, PMID 19181226, PMID 19207738, PMID 19446324, PMID 19457636, PMID 19458364, PMID 19479509, PMID 19525472, PMID 19703733, PMID 19774309, PMID 19782873, PMID 19933962, PMID 19953081, PMID 20083680, PMID 20369058, PMID 20396457, PMID 20439512, PMID 2044064, PMID 20447554, PMID 20595866, PMID 20634793, PMID 20647575, PMID 20731734, PMID 2077396, PMID 20798172

NIH funding

U01DK097772 (3), U01DK097779 (3), U01DK097780 (3), U01DK099879 (3), U01DK099932 (3), U01DK100011 (3), U01DK100017 (3), U19AT004663 (3), U54NS065712 (3), K12DK083021 (2), K23AG030945 (2), P01HL046925 (2), P30CA086862 (2), R01HL144718 (2), R01MD018609 (2)