14 completed, 5 recruiting, 5 unknown, 1 active not recruiting. 9 Not applicable, 5 Phase 3, 4 Early Phase 1, 3 Phase 1, 3 Phase 2.
Follow Phentolamine: new trials by email Literature Review of Phentolamine trials Research Report on Phentolamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Role of the Adrenergic System in Hypoglycaemia Induced Inflammatory Response in People With Type 1 Diabetes and People Without Type 1 Diabetes-RAID-II hyperinsulinaemic hypoglycaemic clamp, Propranolol Hydrochloride 1 MG/ML, Phentolamine - Diabetes Mellitus, Type 1, Inflammation | Not applicable | Completed | Radboud University Medical Center | 24 | 2025-09-28 | 2026-08-13 |
| Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms Propranolol Hydrochloride, Phentolamine Injection - Menopause | Early Phase 1 | Recruiting | University of Missouri-Columbia | 75 | 2025-07-10 | 2025-09-15 |
| Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children OraVerse - Soft Tissue Injuries | Phase 3 | Recruiting | Cairo University | 100 | 2025-07-05 | 2025-07-10 |
| Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery Phentolamine, Esmolol - Preoperative, Phentolamine | Not applicable | Unknown | Ain Shams University | 60 | 2024-10-10 | 2024-10-01 |
| Intravenous Labetalol vs Phentolamine for the Management of Severe Preeclampsia. Labetalol, Phentolamine - Severe Pre-eclampsia | Not applicable | Unknown | Assiut University | 200 | 2024-05-20 | 2024-04-26 |
| Efficacy of Phentolamine in Prevention of Contrast-Associated Acute Kidney Injury After Complex PCI Phentolamine - CA-AKI - Contrast-Associated Acute Kidney Injury, Coronary Artery Disease | Phase 2 / Phase 3 | Unknown | Helwan University | 60 | 2024-03-07 | 2024-03-18 |
| Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate - Vasoconstriction, Vasodilation | Phase 4 | Recruiting | University of Alberta | 30 | 2023-10-31 | 2026-01-08 |
| Sex Disparities in Hypoxic Vasodilation and Impact of Obesity Propranolol Hydrochloride, Isoproterenol, Phentolamine Mesylate - Obesity, Vasodilation | Early Phase 1 | Recruiting | University of Missouri-Columbia | 72 | 2023-03-14 | 2026-07-28 |
| Sex Differences in Sympathetic Vascular Reactivity at High Altitude Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 17 | 2022-07-28 | 2024-09-19 |
| New Perspective on Exploring the Post-apneic BP Surge in Patients With OSA Phentolamine Injection - Obstructive Sleep Apnea | Early Phase 1 | Unknown | Xu J | 350 | 2022-04-01 | 2023-12-15 |
| Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity Phentolamine, Saline, Sodium Nitroprusside - Insulin Resistance, Healthy | Phase 1 | Active not recruiting | Vanderbilt University Medical Center | 36 | 2017-10-24 | 2026-03-02 |
| A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems Albuterol Sulfate, Nicardipine Hydrochloride, Dobutamine Hydrochloride - Drug-Related Side Effects and Adverse Reactions, Cardiovascular System Disease | Phase 1 | Terminated | Cambridge University Hospitals NHS Foundation Trust | 18 | 2017-04-24 | 2021-03-22 |
| Reversing the Effects of 0.5% Bupivacaine OraVerse, Saline Water (Control) - Anesthesia, Local | Phase 4 | Completed | Dalhousie University | 44 | 2017-02-10 | 2020-01-29 |
| Adrenergic System in Islet Transplantation Phentolamine, Propranolol, Placebo - Type1diabetes, Hypoglycemia | Early Phase 1 | Completed | University of Pennsylvania | 9 | 2017-01-20 | 2026-04-27 |
| Phentolamine Mesylate as a Reversal of Local Anesthesics Phentolamine Mesylate 0.235 MG/ML [OraVerse] - Anesthesia, Local | Not applicable | Completed | León Formación | 90 | 2016-01-01 | 2018-11-14 |
| Reversing the Effects of 2% Lidocaine Phentolamine mesylate, Water - Soft Tissue Anaesthesia | Not applicable | Completed | Dalhousie University | 38 | 2015-10-01 | 2016-10-14 |
| Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) Low-dose rtPA, Standard-dose rtPA, Intensive blood pressure (BP) lowering - Ischemic Stroke, High Blood Pressure | Phase 3 | Completed | The George Institute | 4587 | 2012-03-01 | 2021-10-13 |
| Study of OraVerse® for Safety and Efficacy in Pediatric Dental Patients OraVerse, Sham injection - Dental Anesthesia, Anesthesia, Local | Phase 4 | Completed | Novocol Pharmaceutical of Canada, Inc. | 150 | 2012-02-01 | 2014-08-29 |
| : Vascular Function in Health and Disease Maximum Exercise Tests, BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate, BQ-123 - Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension | Phase 1 | Recruiting | D. Walter Wray | 420 | 2008-09-01 | 2026-09-25 |
| The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial Blood pressure management policies - Intracerebral Hemorrhage, Stroke | Not applicable | Completed | The George Institute | 2839 | 2008-09-01 | 2013-12-13 |
Showing 20 of 26. Sign in to see all of them.
Aneurysm (3) · Hypertension (3) · Hypesthesia (3) · Cerebral Hemorrhage (2) · Heart Failure (2) · Obesity (2) · Stroke (2) · Acute Coronary Syndrome (1) · Cardiovascular Diseases (1) · Coronary Artery Disease (1) · Diabetes Mellitus, Type 1 (1) · Drug-Related Side Effects and Adverse Reactions (1) · Familial Primary Pulmonary Hypertension (1) · Hypoglycemia (1) · Infertility (1)
Novalar Pharmaceuticals, Inc. (3) · The George Institute (3) · Dalhousie University (2) · Radboud University Medical Center (2) · University of Alberta (2) · University of Missouri-Columbia (2) · Ain Shams University (1) · Assiut University (1) · Cairo University (1) · Cambridge University Hospitals NHS Foundation Trust (1) · D. Walter Wray (1) · Helwan University (1) · León Formación (1) · M.D. Anderson Cancer Center (1) · Novocol Pharmaceutical of Canada, Inc. (1)
United States (11) · Canada (4) · Australia (3) · China (3) · Egypt (3) · Netherlands (2) · United Kingdom (2) · Argentina (1) · Austria (1) · Belgium (1) · Brazil (1) · Chile (1) · Finland (1) · France (1) · Germany (1)
Athena Papas, DMD (2) · Craig Anderson, PhD (2) · Sean van Diepen, MD, MSc (2) · Adam Marberger, DDS (1) · Arafa Gomaa, MD (1) · Brent Lin, DMD (1) · Bruce Neal, PhD (1) · Cees J Tack, MD, PhD (1) · Cees Tack, MD, PhD (1) · Christopher G. Wood, MD (1) · Craig D Steinback, PhD (1) · Craig S Anderson, MD (1) · Craig Steinback, PhD (1) · David W Wray, Ph.D. (1) · Elliot Hersh, DMD,MS,PhD (1)
PMID 32640944, PMID 25503550, PMID 25589782, PMID 25657175, PMID 25712944, PMID 25823544, PMID 26746184, PMID 27165954, PMID 27178897, PMID 27919055, PMID 30890109, PMID 31085948, PMID 33598552, PMID 38018833, PMID 40541207, PMID 41855454, PMID 42848972, PMID 18396107, PMID 18547152, PMID 18573982, PMID 18682623, PMID 18682624, PMID 18783876, PMID 20823381, PMID 20831927, PMID 21924181, PMID 22129475, PMID 22678090, PMID 22744655, PMID 23522530, PMID 23713578, PMID 24149007, PMID 24530176, PMID 25497513, PMID 25677598, PMID 25801872, PMID 26044442, PMID 26202097, PMID 26265125, PMID 26409985, PMID 26810526, PMID 26814235, PMID 26846860, PMID 26859491, PMID 27009893, PMID 27073236, PMID 27143274, PMID 27161018, PMID 27831492, PMID 28126226
P30CA016672 (1), P50CA090270 (1), R01DK091331 (1)