14 completed, 6 unknown, 2 terminated, 1 recruiting. 23 Phase 2, 8 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 23 | Completed 14, Unknown 6, Terminated 2, Recruiting 1 |
| Phase 3 | 8 | Completed 6, Terminated 1, Unknown 1 |
| Phase 1 | 1 | Unknown 1 |
Follow Trypanosomiasis: new trials by email Literature Review of Trypanosomiasis trials Research Report on Trypanosomiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease. LXE408, Placebo, Benznidazole - Chagas Disease | Phase 2 | Recruiting | Novartis Pharmaceuticals | 130 | 2025-04-28 | 2026-11-10 |
| Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients Acoziborole - Trypanosomiasis, African, Trypanosoma Brucei Gambiense; Infection | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 35 | 2022-07-09 | 2026-04-06 |
| Safety and Tolerability Study of Acoziborole in g-HAT Seropositive Subjects Acoziborole, Placebo - Trypanosomiasis, African, Trypanosoma Brucei Gambiense; Infection | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 1208 | 2021-12-30 | 2025-03-20 |
| Atorvastatin on Inflammation and Cardiac Function in Chronic Chagas Disease 40 mg Atorvastatin/day for 120 days P.O., Atorvastatin 80, Placebo - Chronic Chagas Disease | Phase 2 | Terminated | Juan D. Maya | 300 | 2021-10-12 | 2024-09-19 |
| SBRT in Chagas Disease Ventricular Tachycardia Stereotactic Body Radiation Therapy - Ventricular Tachycardia, Chagas Disease | Phase 1 / Phase 2 | Unknown | University of Sao Paulo General Hospital | 10 | 2021-07-14 | 2024-07-16 |
| New Therapies and Biomarkers for Chagas Infection Benznidazole, Nifurtimox - Trypanosoma Cruzi Infection, Chagas Disease | Phase 2 | Completed | University of Texas, El Paso | 450 | 2019-12-18 | 2024-07-17 |
| Fexinidazole in Human African Trypanosomiasis Due to T. b. Rhodesiense Fexinidazole - Trypanosomiasis, African, Sleeping Sickness | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 45 | 2019-09-29 | 2025-01-30 |
| Colchicine for Patients With Chagas´ Disease( B1 Stage) Colchicine 0.5 MG twice day for one year, Placebo Oral Tablet - Chagas Disease, Colchicine Resistance | Phase 2 | Unknown | University of Sao Paulo General Hospital | 60 | 2018-10-01 | 2019-03-11 |
| Oral Fexinidazole Dosing Regimens for the Treatment of Adults With Chronic Indeterminate Chagas Disease Fexinidazole, Placebo Oral Tablet - Chagas' Disease (Chronic) Nos | Phase 2 | Completed | Drugs for Neglected Diseases | 45 | 2017-11-13 | 2020-09-23 |
| Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease. Benznidazole - Chagas Disease, Trypanosoma Cruzi Infection | Phase 2 | Completed | Hospital Universitari Vall d'Hebron Research Institute | 238 | 2017-04-21 | 2023-12-19 |
| BENDITA BEnznidazole New Doses Improved Treatment and Associations Benznidazole, E1224, E1224 Placebo - Chagas Disease | Phase 2 | Unknown | Drugs for Neglected Diseases | 210 | 2016-11-30 | 2017-12-20 |
| Efficacy and Safety of Acoziborole (SCYX-7158) in Patients With Human African Trypanosomiasis Due to T.b. Gambiense Acoziborole - Trypanosomiasis, African, Gambiense Trypanosomiasis | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 208 | 2016-10-11 | 2025-09-17 |
| Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas Cardiomyopathy Treatment with G-CSF (Granulocyte colony stimulating factor), Placebo saline - Chronic Chagasic Myocarditis | Phase 2 | Completed | Hospital Sao Rafael | 70 | 2015-09-01 | 2020-08-24 |
| CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) Nifurtimox, Benznidazole, Placebo - Chagas Disease | Phase 2 / Phase 3 | Unknown | Universidad Autónoma de Bucaramanga | 500 | 2015-08-01 | 2017-07-21 |
| Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas Disease Fexinidazole, Placebo - Chagas Disease, Trypanosomiasis, South American | Phase 2 | Unknown | Drugs for Neglected Diseases | 140 | 2014-07-01 | 2015-07-15 |
| Cardiac Rehabilitation in Chagas Heart Failure Exercise, nutritional and pharmaceutical counseling - Chagas Disease, Chagas Cardiomyopathy | Phase 2 / Phase 3 | Completed | Evandro Chagas National Institute of Infectious Disease | 12 | 2013-05-01 | 2015-08-05 |
| Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2 Fexinidazole, Nifurtimox, Eflornithine - Human African Trypanosomiasis (HAT), Sleeping Sickness | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 394 | 2012-10-01 | 2018-02-20 |
| A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) Posaconazole, Placebo for posaconazole, Benznidazole - Chagas Disease | Phase 2 | Completed | Merck Sharp & Dohme LLC | 120 | 2011-07-06 | 2018-08-27 |
| Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease E1224, Benznidazole, Placebo - Chronic Chagas Disease, Indeterminate | Phase 2 | Unknown | Drugs for Neglected Diseases | 230 | 2011-06-01 | 2011-12-21 |
| Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole Benznidazole, Posaconazole - Chagas Disease | Phase 2 | Completed | Hospital Universitari Vall d'Hebron Research Institute | 78 | 2010-09-01 | 2013-09-10 |
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Chagas Disease (15) · Trypanosomiasis, African (8) · Infections (3) · Bronchiolitis Obliterans Syndrome (2) · Inflammation (2) · Arrhythmias, Cardiac (1) · Chagas Cardiomyopathy (1) · Fibrosis (1) · Neglected Diseases (1) · Parasitic Diseases (1) · Pyloric Stenosis, Hypertrophic (1) · Tachycardia, Ventricular (1)
Euglenozoa Infections (23) · Protozoan Infections (23) · Vector Borne Diseases (23) · Parasitic Diseases (22) · Infections (20) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Bronchial Diseases (2) · Bronchiolitis (2) · Bronchiolitis Obliterans (2) · Bronchitis (2) · Cardiovascular Diseases (2) · Graft vs Host Disease (2) · Heart Diseases (2)
benzonidazole (8) · fexinidazole (4) · Nifurtimox (3) · Eflornithine (2) · Prodrugs (2) · posaconazole (2) · Colchicine (1) · Control Groups (1) · Exercise (1) · Granulocyte Colony-Stimulating Factor (1) · LXE408 (1) · Pentamidine (1) · Radiosurgery (1) · SCYX 7158 (1) · Sodium Chloride (1)
Drugs for Neglected Diseases (9) · Hospital Universitari Vall d'Hebron Research Institute (2) · Immtech Pharmaceuticals, Inc (2) · University of Sao Paulo General Hospital (2) · Epicentre (1) · Evandro Chagas National Institute of Infectious Disease (1) · Hospital Sao Rafael (1) · Juan D. Maya (1) · Merck Sharp & Dohme LLC (1) · Novartis Pharmaceuticals (1) · Universidad Autónoma de Bucaramanga (1) · University of Texas, El Paso (1)
Brazil (6) · Bolivia (4) · Democratic Republic of the Congo (4) · Colombia (3) · Guinea (3) · Republic of the Congo (3) · Spain (3) · Argentina (2) · Uganda (2) · Angola (1) · Central African Republic (1) · Chile (1) · Malawi (1) · United States (1)
Faustino Torrico, PhD (2) · Andrea S Sousa, PhD (1) · Bruno SF Souza, MD, Msc (1) · Carolina T Macedo, MD, Msc (1) · Christian Burri, MSc, PhD (1) · Clarissa LM Souza, MD (1) · Enock Matovu, Prof (1) · Fabio Fernandes, Md, PHD (1) · Faustino Torrico, M.D., Ph.D (1) · Faustino Torrico, MD (1) · Gerardo Priotto, MD MPH (1) · Gomez Jordi, MD (1) · Igor C Almeida, D.Sc. (1)
PMID 26881924, PMID 24827034, PMID 28231946, PMID 29113731, PMID 29352704, PMID 30509941, PMID 31307503, PMID 32293523, PMID 33836161, PMID 34972765, PMID 35757326, PMID 35925555, PMID 36409773, PMID 36460027, PMID 36638112, PMID 38218194, PMID 38218195, PMID 39627222, PMID 40288400, PMID 40982532, PMID 42772313
2016 (2), U01AI129783 (1)