31 completed, 3 not yet recruiting, 3 terminated, 2 withdrawn. 11 Phase 2, 10 Not applicable, 10 Phase 1, 10 Phase 3, 2 Phase 4.
Follow Pentamidine: new trials by email Literature Review of Pentamidine trials Research Report on Pentamidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study Comparing Several Drugs to Understand Which Work Against Cutaneous Leishmaniasis (CL) Sodium Stibogluconate (SSG), Miltefosine, Miltefosine + Paromomycin - Cutaneous Leihmaniasis | Phase 3 | Not yet recruiting | Institute of Tropical Medicine, Belgium | 900 | 2027-01-01 | 2026-03-10 |
| Modified FOLFIRINOX and Pentamidine in Advanced and Metastatic Pancreatic Cancer modified FOLFIRINOX, Pentamidine 300 MG Injection - Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 1 | Not yet recruiting | University of Oklahoma | 30 | 2026-12-01 | 2026-09-18 |
| Positioning Second-line Therapies for Pneumocystis Jirovecii Pneumonia (PCP Alternatives) Clindamycin + primaquine, Pentamidine, Atovaquone - Pneumocystis, Pneumocystis Infection | Phase 4 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 416 | 2026-03-01 | 2026-01-21 |
| Pentamidine + Salvage Chemo for Relapsed/Refractory Classical Hodgkin Lymphoma Pentamidine - Hodgkin Lymphoma, Refractory Hodgkin Lymphoma | Phase 1 | Completed | Reinhold Munker | 1 | 2018-12-19 | 2021-07-07 |
| Hypertrophic Scar Prevention by Novel Topical Gel Application Pentamidine Isethionate, Placebo - Hypertrophic Scar | Phase 1 / Phase 2 | Terminated | Mayo Clinic | 6 | 2018-03-05 | 2023-11-22 |
| A Pilot, Dose Escalating Study on VLX103 in Moderate Alcoholic Steatohepatitis VLX103 - Hepatic Steatosis | Phase 1 | Withdrawn | Gyongyi Szabo | 2017-06-25 | 2018-05-30 | |
| Topical Paromomycin for Cutaneous Leishmaniasis in Bolivia Paromomycin Sulfate, Pentamidine Isethionate, Placebo - Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex | Phase 2 / Phase 3 | Completed | Fundacion Nacional de Dermatologia | 80 | 2017-04-15 | 2021-02-02 |
| Intravenous Pentamidine for Pneumocystis Jirovecii Pneumonia Pentamidine - Hematologic Malignancy | Completed | University of Illinois at Chicago | 50 | 2015-03-01 | 2016-06-30 | |
| A Phase I Clinical Study on a New Oral Pentamidine Formulation in Hepatocellular Carcinoma Oral Pentamidine, Placebo - Hepatocellular Carcinoma | Phase 1 | Completed | Oncozyme Pharma Inc. | 29 | 2014-08-01 | 2016-03-14 |
| Efficacy and Safety of Pentamidine (7mg/kg) for Patients With Cutaneous Leishmaniasis Caused by L. Guyanensis Single dose of Pentamidine, Two doses of Pentamidine, Three doses of Pentamidine - Cutaneous Leishmaniases | Phase 2 | Completed | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado | 159 | 2014-01-01 | 2019-02-15 |
| Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study Pentamidine - Visceral Leishmaniosis, HIV-infection/Aids | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 74 | 2011-11-01 | 2019-02-15 |
| A Safety Study Using Pentamidine in Patients With Pancreatic Cancer Undergoing Standard Therapy Pentamidine - Pancreatic Cancer | Phase 1 / Phase 2 | Completed | Oncozyme Pharma Inc. | 10 | 2009-01-01 | 2011-06-28 |
| 0794GCC: Pentamidine in Treating Patients With Relapsed or Refractory Melanoma pentamidine - Melanoma (Skin) | Phase 2 | Terminated | University of Maryland, Baltimore | 6 | 2008-07-01 | 2019-08-16 |
| A Safety Study of Pentamidine in Patients With Metastatic Colon Cancer Undergoing Standard Chemotherapy as Second-line and/or Third-line Treatment pentamidine - Colorectal Cancer | Phase 1 / Phase 2 | Completed | Oncozyme Pharma Inc. | 15 | 2008-03-01 | 2011-06-28 |
| Corticosteroids Therapy and Pneumocystis Jirovecii Pneumonia (PCP) Antibiotics only, Antibiotics + Corticosteroids, Corticosteroids + antibiotics - Pneumocystis Carinii Pneumonia | Phase 4 | Withdrawn | George Washington University | 2008-02-01 | 2017-06-27 | |
| Combination Immunosuppressive Therapy to Prevent Kidney Transplant Rejection in Adults Alemtuzumab, Sirolimus, Tacrolimus - Kidney Transplantation, Kidney Disease | Phase 1 / Phase 2 | Completed | University of Wisconsin, Madison | 10 | 2003-11-01 | 2018-06-29 |
| Trial of DB289 for the Treatment of Stage I African Trypanosomiasis DB289, Pentamidine - African Trypanosomiasis | Phase 2 | Completed | Immtech Pharmaceuticals, Inc | 111 | 2003-02-01 | 2008-12-08 |
| Islet Transplantation for Type 1 Diabetes Islet Transplantation, Sirolimus, Tacrolimus - Diabetes Mellitus, Insulin-Dependent | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 36 | 2001-04-01 | 2017-03-15 |
| Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma Bleomycin Sulfate, Filgrastim, Cisplatin - Lymphoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 46 | 1993-06-01 | 2012-07-30 |
| A Double-Blind Placebo-Controlled Group Comparative Study To Evaluate the Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With AIDS Post First Episode PCP Pentamidine isethionate - Pneumonia, Pneumocystis Carinii, HIV Infections | Not applicable | Completed | Fisons | 2005-06-24 |
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Acquired Immunodeficiency Syndrome (22) · Pneumonia, Pneumocystis (22) · HIV Infections (20) · AIDS-Related Opportunistic Infections (16) · Respiratory Aspiration (6) · AIDS-Related Complex (4) · Leishmaniasis, Cutaneous (3) · Pneumonia (2) · Carcinoma, Hepatocellular (1) · Cicatrix, Hypertrophic (1) · Colorectal Neoplasms (1) · Diabetes Mellitus, Type 1 (1) · Fatty Liver (1) · HIV Seropositivity (1) · Hematologic Neoplasms (1)
National Institute of Allergy and Infectious Diseases (NIAID) (12) · Fisons (5) · Oncozyme Pharma Inc. (3) · Glaxo Wellcome (2) · Institute of Tropical Medicine, Belgium (2) · LyphoMed (2) · Fundacion Nacional de Dermatologia (1) · Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (1) · George Washington University (1) · Gyongyi Szabo (1) · Immtech Pharmaceuticals, Inc (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Reinhold Munker (1)
United States (30) · Canada (4) · Ethiopia (2) · Bolivia (1) · Germany (1) · Italy (1) · Puerto Rico (1) · Republic of the Congo (1) · Switzerland (1) · Tanzania (1)
B Montgomery (2) · Petr Kavan, MD, Ph.D. (2) · A. D'jamali, MD, MS (1) · Afsoon Roberts, M.D. (1) · Alexander Meves, MD (1) · Anette Talhari, Doctor (1) · ER Stiehm (1) · Edward A. Sausville, MD, PhD (1) · El-Sadr W (1) · Emily G McDonald, MD MSc (1) · Ermias Diro, MD (1) · GC Smaldone (1) · Gyongyi Szabo, MD, PhD (1) · Hardy WD (1) · Hayder Saeed, MD (1)
PMID 15257060, PMID 17005949, PMID 23438305, PMID 26881924, PMID 29020217, PMID 29269796, PMID 29654388, PMID 30260376, PMID 30379814, PMID 32479781, PMID 34988242, PMID 38235979
P30CA016672 (1), R21CA135624 (1), U01AA021893 (1)