14 completed, 4 unknown, 3 terminated, 2 recruiting. 25 Phase 3, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 25 | Completed 14, Unknown 4, Terminated 3, Recruiting 2, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 8 | Completed 6, Terminated 1, Unknown 1 |
Follow Trypanosomiasis: new trials by email Literature Review of Trypanosomiasis trials Research Report on Trypanosomiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Short Benznidazole Regimen for Chronic Phase Chagas Disease Patients benznidazole 300 mg daily 8 weeks - Chronic Chagas Disease | Phase 3 | Withdrawn | Evandro Chagas Institute of Clinical Research | 2025-01-30 | 2025-03-13 | |
| Stop Transmission of Gambiense Human African Trypanosomiasis Acoziborole - Trypanosomiasis; African, Due to Trypanosoma Brucei Gambiense, Gambiense | Phase 3 | Recruiting | Institute of Tropical Medicine, Belgium | 2500 | 2024-03-15 | 2026-08-27 |
| Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients Acoziborole - Trypanosomiasis, African, Trypanosoma Brucei Gambiense; Infection | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 35 | 2022-07-09 | 2026-04-06 |
| Safety and Tolerability Study of Acoziborole in g-HAT Seropositive Subjects Acoziborole, Placebo - Trypanosomiasis, African, Trypanosoma Brucei Gambiense; Infection | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 1208 | 2021-12-30 | 2025-03-20 |
| Shorter Benznidazole Regimens Compared to the Standard Regimen for Chagas Disease Short regimen of benznidazole, Short treatment with benznidazole, Standard treatment with benznidazole - Chagas Disease | Phase 3 | Recruiting | Laboratorio Elea Phoenix S.A. | 300 | 2021-07-28 | 2023-11-30 |
| Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF. Sacubitril / Valsartan Oral Tablet [Entresto], Enalapril - Chagas Cardiomyopathy | Phase 3 | Unknown | University of Sao Paulo General Hospital | 200 | 2021-05-06 | 2024-04-04 |
| Fexinidazole in Human African Trypanosomiasis Due to T. b. Rhodesiense Fexinidazole - Trypanosomiasis, African, Sleeping Sickness | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 45 | 2019-09-29 | 2025-01-30 |
| Prospective Study of Benznidazole for Chagas' Disease Children With Chronic Indeterminate Chagas Disease Benznidazole - Chagas Disease | Phase 3 | Active not recruiting | Insud Pharma | 178 | 2019-09-19 | 2026-04-21 |
| Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age Benznidazole, Placebo Oral Tablet - Chagas Disease | Phase 3 | Completed | Tulane University School of Public Health and Tropical Medicine | 87 | 2019-06-01 | 2026-04-09 |
| A Trial Testing Amiodarone in Chagas Cardiomiopathy Amiodarone Hydrochloride, Placebo Oral Tablet - Chagas Cardiomyopathy | Phase 3 | Unknown | Fundación Cardioinfantil Instituto de Cardiología | 200 | 2017-06-12 | 2017-06-21 |
| Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage Fexinidazole - Trypanosomiasis, African, Sleeping Sickness | Phase 3 | Completed | Drugs for Neglected Diseases | 174 | 2016-11-10 | 2025-01-08 |
| Efficacy and Safety of Acoziborole (SCYX-7158) in Patients With Human African Trypanosomiasis Due to T.b. Gambiense Acoziborole - Trypanosomiasis, African, Gambiense Trypanosomiasis | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 208 | 2016-10-11 | 2025-09-17 |
| A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Disease, an Inflammatory, Infectious Disease Caused by the Parasite Trypanosoma Cruzi Nifurtimox (Lampit, BAYA2502), Placebo - Chagas Disease | Phase 3 | Completed | Bayer | 330 | 2016-01-27 | 2024-08-19 |
| CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) Nifurtimox, Benznidazole, Placebo - Chagas Disease | Phase 2 / Phase 3 | Unknown | Universidad Autónoma de Bucaramanga | 500 | 2015-08-01 | 2017-07-21 |
| Physical Exercise Program in Chronic Chagas Heart Disease Exercise, nutritional and pharmaceutical counceling, Nutritional and pharmaceutical counceling - Chagas Disease, Chagas Cardiomyopathy | Phase 3 | Completed | Evandro Chagas National Institute of Infectious Disease | 30 | 2015-03-01 | 2017-07-27 |
| Cardiac Rehabilitation in Chagas Heart Failure Exercise, nutritional and pharmaceutical counseling - Chagas Disease, Chagas Cardiomyopathy | Phase 2 / Phase 3 | Completed | Evandro Chagas National Institute of Infectious Disease | 12 | 2013-05-01 | 2015-08-05 |
| Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2 Fexinidazole, Nifurtimox, Eflornithine - Human African Trypanosomiasis (HAT), Sleeping Sickness | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 394 | 2012-10-01 | 2018-02-20 |
| Selenium Treatment and Chagasic Cardiopathy (STCC) Selenium, Placebo (for Selenium) - Chagas Disease | Phase 3 | Unknown | Oswaldo Cruz Foundation | 130 | 2008-10-01 | 2015-11-10 |
| Cell Therapy in Chagas Cardiomyopathy Stem cell, Filgrastime (G-CSF), Standart therapy - Chagas Cardiomyopathy | Phase 3 | Terminated | Ministry of Health, Brazil | 182 | 2006-01-01 | 2017-03-13 |
| BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Benznidazole, Placebo - Chagas Disease, Trypanosomiasis | Phase 3 | Completed | Population Health Research Institute | 2854 | 2004-11-01 | 2020-03-03 |
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Chagas Disease (13) · Trypanosomiasis, African (9) · Chagas Cardiomyopathy (6) · Infections (3) · Heart Failure (2) · Cardiomyopathies (1) · Cardiomyopathy, Dilated (1) · Heart Diseases (1) · Motor Activity (1) · Neglected Diseases (1)
Euglenozoa Infections (25) · Parasitic Diseases (25) · Protozoan Infections (25) · Vector Borne Diseases (24) · Infections (22) · Cardiovascular Diseases (7) · Heart Diseases (6) · Cardiomyopathies (5) · Chagas Disease (2) · Behavior (1) · Cardiomegaly (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Disease Attributes (1) · Genetic Diseases, Inborn (1)
benzonidazole (7) · Nifurtimox (5) · Eflornithine (4) · fexinidazole (3) · Exercise (2) · Amiodarone (1) · Angiotensin-Converting Enzyme Inhibitors (1) · Bisoprolol (1) · Control Groups (1) · Enalapril (1) · Granulocyte Colony-Stimulating Factor (1) · Melarsoprol (1) · SCYX 7158 (1) · Selenium (1) · Valsartan (1)
Drugs for Neglected Diseases (7) · Epicentre (2) · Evandro Chagas National Institute of Infectious Disease (2) · Bayer (1) · Evandro Chagas Institute of Clinical Research (1) · Fundación Cardioinfantil Instituto de Cardiología (1) · Fundación Cardiovascular de Colombia (1) · Institute of Tropical Medicine, Belgium (1) · Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (1) · Insud Pharma (1) · Laboratorio Elea Phoenix S.A. (1) · Ministry of Health, Brazil (1) · Oswaldo Cruz Foundation (1) · Population Health Research Institute (1) · Tulane University School of Public Health and Tropical Medicine (1)
Brazil (7) · Democratic Republic of the Congo (7) · Argentina (6) · Colombia (6) · Guinea (4) · Bolivia (3) · Uganda (3) · Republic of the Congo (2) · Central African Republic (1) · El Salvador (1) · Malawi (1) · United States (1)
Gerardo Priotto, MD, MPH (2) · Adellina R Riarte, MD (1) · Andrea S Sousa, PhD (1) · Carlos A Morillo, MD, FRCPC (1) · Carlos Morillo, MD (1) · Diego A Rodriguez, MD (1) · Digas Ngolo Tete, MPH (1) · Elena Nicco (1) · Els Torreele, PhD (1) · Enock Matovu, Prof (1) · Fernanda Mendes, M.D. (1) · Fernando Rosas, M.D. (1) · Gerardo Priotto, MD MPH (1)
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