11 completed, 1 terminated, 1 unknown. 13 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 13 | Completed 11, Terminated 1, Unknown 1 |
| Phase 2 | 1 | Unknown 1 |
Follow Trypanosomiasis: new trials by email Literature Review of Trypanosomiasis trials Research Report on Trypanosomiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| First-in-Human Trial of Oral AN2-502998 AN2-502998, Placebo - Healthy Volunteers | Phase 1 | Completed | AN2 Therapeutics, Inc | 72 | 2025-08-04 | 2026-04-30 |
| DDI Study of Single Oral Dose of Acoziborole With Sequential Co-administration of Midazolam and Dextromethorphan Acoziborole, Midazolam, Dextromethorphan - Trypanosomiasis, African | Phase 1 | Completed | Drugs for Neglected Diseases | 20 | 2023-02-09 | 2023-07-17 |
| SBRT in Chagas Disease Ventricular Tachycardia Stereotactic Body Radiation Therapy - Ventricular Tachycardia, Chagas Disease | Phase 1 / Phase 2 | Unknown | University of Sao Paulo General Hospital | 10 | 2021-07-14 | 2024-07-16 |
| ADME Study of Acoziborole in Healthy Subjects [14C]-acoziborole capsule, 240 mg containing NMT 9.25 kBq (250 nCi) 14C - Trypanosomiases, African | Phase 1 | Completed | Drugs for Neglected Diseases | 6 | 2020-02-05 | 2021-04-27 |
| Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits Study Nifurtimox (Lampit, BAYA2502) - Chagas' Disease | Phase 1 | Completed | Bayer | 36 | 2019-06-10 | 2020-12-30 |
| A First-in-human, Safety, Tolerability, and Pharmacokinetics Study of LXE408 in Healthy Subjects LXE408, Placebo, Iohexol - Visceral Leishmaniasis, Chagas Disease | Phase 1 | Completed | Novartis Pharmaceuticals | 88 | 2018-12-21 | 2026-09-09 |
| Study Will Evaluate the Relative Bioavailability, Safety, and Tolerability of Single Doses of Nifurtimox 30 mg Tablets Exhibiting Different in Vitro Dissolution Characteristics, and to Evaluate the Relative Bioavailability of Nifurtimox 30 mg and 120 mg Nifurtimox (Lampit, BAYA2502) - Chagas Disease | Phase 1 | Completed | Bayer | 48 | 2018-06-14 | 2019-12-12 |
| Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients Nifurtimox (BAYa2502) - Chagas Disease | Phase 1 | Completed | Bayer | 36 | 2015-12-01 | 2016-11-15 |
| Bioequivalence Study - Reference Clinical Fexinidazole Tablet Versus Proposed Market Formulation Fexinidazole - Trypanosomiasis, African | Phase 1 | Completed | Drugs for Neglected Diseases | 30 | 2015-03-01 | 2015-10-08 |
| Pharmacokinetic Drug-Drug Interaction Study Benznidazole, E1224 - Chagas Disease | Phase 1 | Completed | Drugs for Neglected Diseases | 28 | 2014-10-01 | 2019-03-27 |
| Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients Nifurtimox (BAYa2502) (4 x 30 mg tablet), Nifurtimox (BAYa2502) (slurry of 4 x 30 mg tablets in tap water), Nifurtimox (BAYa2502) (120 mg tablet) - Chagas Disease | Phase 1 | Completed | Bayer | 37 | 2013-11-01 | 2015-10-16 |
| Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158 SCYX-7158, Placebo - Trypanosomiasis, Trypanosomiasis, African | Phase 1 | Completed | Drugs for Neglected Diseases | 136 | 2012-02-01 | 2015-09-18 |
| Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With Food Tablets Fexinidazole, Placebo - Trypanosomiasis, African | Phase 1 | Terminated | Drugs for Neglected Diseases | 30 | 2011-09-01 | 2017-03-31 |
Chagas Disease (8) · Trypanosomiasis, African (5) · Arrhythmias, Cardiac (1) · Leishmaniasis, Visceral (1) · Neglected Diseases (1) · Parasitic Diseases (1) · Protozoan Infections (1) · Tachycardia, Ventricular (1)
Euglenozoa Infections (13) · Infections (13) · Vector Borne Diseases (13) · Parasitic Diseases (12) · Protozoan Infections (12) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Cardiac Conduction System Disease (1) · Cardiovascular Diseases (1) · Disease Attributes (1) · Heart Diseases (1) · Leishmaniasis (1) · Tachycardia (1)
Nifurtimox (4) · fexinidazole (2) · Dextromethorphan (1) · Iohexol (1) · LXE408 (1) · Midazolam (1) · Radiosurgery (1) · SCYX 7158 (1) · Tablets (1) · benzonidazole (1)
Drugs for Neglected Diseases (6) · Bayer (4) · AN2 Therapeutics, Inc (1) · Novartis Pharmaceuticals (1) · University of Sao Paulo General Hospital (1)
Argentina (5) · France (3) · Australia (1) · Brazil (1) · Malaysia (1) · United Kingdom (1) · United States (1)
Antoine Tarral, MD (2) · Ethel Feleder, MD (1) · Isabela Ribeiro, MD (1) · Lionel Hovsepian, MD (1) · Mauricio I Scanavacca, MD, PhD (1) · Sharan Sidhu, MBChB (1) · Sharon Ng Shi Min (1)