13 completed, 3 unknown, 2 recruiting, 1 active not recruiting. 8 Phase 2, 7 Phase 3, 2 Phase 1, 2 Phase 4, 1 Not applicable.
Follow benzonidazole: new trials by email Literature Review of benzonidazole trials Research Report on benzonidazole
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease. LXE408, Placebo, Benznidazole - Chagas Disease | Phase 2 | Recruiting | Novartis Pharmaceuticals | 130 | 2025-04-28 | 2026-10-15 |
| Short Benznidazole Regimen for Chronic Phase Chagas Disease Patients benznidazole 300 mg daily 8 weeks - Chronic Chagas Disease | Phase 3 | Withdrawn | Evandro Chagas Institute of Clinical Research | 2025-01-30 | 2025-03-13 | |
| A Phase 1 Study of the Safety and Tolerability of ICM20 in Adults ICM20, Benznidazole - Safety Issues | Phase 1 | Completed | IC-MedTech Corporation | 13 | 2023-08-20 | 2026-04-16 |
| Shorter Benznidazole Regimens Compared to the Standard Regimen for Chagas Disease Short regimen of benznidazole, Short treatment with benznidazole, Standard treatment with benznidazole - Chagas Disease | Phase 3 | Recruiting | Laboratorio Elea Phoenix S.A. | 300 | 2021-07-28 | 2023-11-30 |
| New Therapies and Biomarkers for Chagas Infection Benznidazole, Nifurtimox - Trypanosoma Cruzi Infection, Chagas Disease | Phase 2 | Completed | University of Texas, El Paso | 450 | 2019-12-18 | 2024-07-17 |
| Prospective Study of Benznidazole for Chagas' Disease Children With Chronic Indeterminate Chagas Disease Benznidazole - Chagas Disease | Phase 3 | Active not recruiting | Insud Pharma | 178 | 2019-09-19 | 2026-04-21 |
| Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age Benznidazole, Placebo Oral Tablet - Chagas Disease | Phase 3 | Completed | Tulane University School of Public Health and Tropical Medicine | 87 | 2019-06-01 | 2026-04-09 |
| Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease. Benznidazole - Chagas Disease, Trypanosoma Cruzi Infection | Phase 2 | Completed | Hospital Universitari Vall d'Hebron Research Institute | 238 | 2017-04-21 | 2023-12-19 |
| BENDITA BEnznidazole New Doses Improved Treatment and Associations Benznidazole, E1224, E1224 Placebo - Chagas Disease | Phase 2 | Unknown | Drugs for Neglected Diseases | 210 | 2016-11-30 | 2017-12-20 |
| CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) Nifurtimox, Benznidazole, Placebo - Chagas Disease | Phase 2 / Phase 3 | Unknown | Universidad Autónoma de Bucaramanga | 500 | 2015-08-01 | 2017-07-21 |
| Pharmacokinetic Drug-Drug Interaction Study Benznidazole, E1224 - Chagas Disease | Phase 1 | Completed | Drugs for Neglected Diseases | 28 | 2014-10-01 | 2019-03-27 |
| New Tools for the Diagnosis, Prognosis and Treatment Follow-up in Chagas Disease Benznidazole - Chagas Disease | Completed | Barcelona Centre for International Health Research | 63 | 2012-12-01 | 2016-08-22 | |
| Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease Benznidazole - Chagas Disease | Phase 4 | Completed | Barcelona Centre for International Health Research | 52 | 2012-12-01 | 2015-05-27 |
| A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) Posaconazole, Placebo for posaconazole, Benznidazole - Chagas Disease | Phase 2 | Completed | Merck Sharp & Dohme LLC | 120 | 2011-07-06 | 2018-08-27 |
| Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease E1224, Benznidazole, Placebo - Chronic Chagas Disease, Indeterminate | Phase 2 | Unknown | Drugs for Neglected Diseases | 230 | 2011-06-01 | 2011-12-21 |
| Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease Benznidazole - Chagas Disease | Phase 4 | Completed | Drugs for Neglected Diseases | 220 | 2011-04-01 | 2018-06-25 |
| Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole Benznidazole, Posaconazole - Chagas Disease | Phase 2 | Completed | Hospital Universitari Vall d'Hebron Research Institute | 78 | 2010-09-01 | 2013-09-10 |
| Population Pharmacokinetics of Benznidazole in Children With Chagas Disease Benznidazole - Chagas Disease | Not applicable | Completed | Hospital de Niños R. Gutierrez de Buenos Aires | 37 | 2007-04-01 | 2011-08-01 |
| BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Benznidazole, Placebo - Chagas Disease, Trypanosomiasis | Phase 3 | Completed | Population Health Research Institute | 2854 | 2004-11-01 | 2020-03-03 |
| Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial Benznidazole, Placebo - Chagas Disease | Phase 3 | Completed | Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben | 910 | 1999-03-01 | 2015-03-11 |
Chagas Disease (19) · Bronchiolitis Obliterans Syndrome (1) · Disease (1) · Heart Diseases (1) · Neglected Diseases (1) · Parasitic Diseases (1) · Trypanosomiasis (1)
Drugs for Neglected Diseases (4) · Barcelona Centre for International Health Research (2) · Hospital Universitari Vall d'Hebron Research Institute (2) · Evandro Chagas Institute of Clinical Research (1) · Hospital de Niños R. Gutierrez de Buenos Aires (1) · IC-MedTech Corporation (1) · Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (1) · Insud Pharma (1) · Laboratorio Elea Phoenix S.A. (1) · Merck Sharp & Dohme LLC (1) · Novartis Pharmaceuticals (1) · Population Health Research Institute (1) · Tulane University School of Public Health and Tropical Medicine (1) · Universidad Autónoma de Bucaramanga (1) · University of Texas, El Paso (1)
Argentina (9) · Bolivia (6) · Colombia (5) · Brazil (4) · Spain (4) · United States (3) · El Salvador (1)
Faustino Torrico, PhD (2) · Isabela Ribeiro, MD (2) · Adellina R Riarte, MD (1) · Carlos Morillo, MD (1) · Ethel Feleder, MD (1) · Facundo Garcia Bournissen, MD (1) · Faustino Torrico, M.D., Ph.D (1) · Fernando Rosas, M.D. (1) · Gideon Koren, MD (1) · Gomez Jordi, MD (1) · Guido Mastrantonio (1) · Igor C Almeida, D.Sc. (1) · Israel Molina, PhD (1) · Jaime Altcheh, MD (1)
PMID 29351667, PMID 30509941, PMID 16235350, PMID 16702588, PMID 19753491, PMID 21264349, PMID 24827034, PMID 24853169, PMID 24867876, PMID 25824212, PMID 26323937, PMID 28231946, PMID 29352704, PMID 31307503, PMID 32293523, PMID 32831069, PMID 33836161, PMID 34972765, PMID 36409773, PMID 38218195, PMID 3835868, PMID 39627222, PMID 40982532, PMID 41027700, PMID 42772313, PMID 8273735, PMID 8937280, PMID 8948328, PMID 9790423
2016 (1), U01AI129783 (1)