3 completed, 2 unknown, 1 recruiting. 3 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Phase 2 | 3 | Unknown 2, Recruiting 1 |
Follow Prodrugs: new trials by email Literature Review of Prodrugs trials Research Report on Prodrugs
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Biomarker Study in Men With Localized Prostate Cancer Treated With Aglatimagene Besadenovec aglatimagene besadenovec + valacyclovir, External Beam Radiation Therapy (EBRT) - Prostate Cancer Patients Treated by Radiotherapy, Prostate Cancer (Adenocarcinoma) | Phase 2 | Recruiting | Candel Therapeutics, Inc. | 45 | 2025-10-30 | 2026-09-15 |
| BENDITA BEnznidazole New Doses Improved Treatment and Associations Benznidazole, E1224, E1224 Placebo - Chagas Disease | Phase 2 | Unknown | Drugs for Neglected Diseases | 210 | 2016-11-30 | 2017-12-20 |
| A Study of the Pharmacokinetics and Safety of BMS-663068 Administered in Subjects With Normal Renal Function and With Mild, Moderate, Severe and End Stage Renal Dysfunction (ESRD) Oral BMS-663068 (pro-drug) - HIV Infections | Phase 1 | Completed | ViiV Healthcare | 30 | 2016-02-26 | 2018-05-15 |
| Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease E1224, Benznidazole, Placebo - Chronic Chagas Disease, Indeterminate | Phase 2 | Unknown | Drugs for Neglected Diseases | 230 | 2011-06-01 | 2011-12-21 |
| A Phase I Study of AdV-tk + Prodrug Therapy in Combination With Radiation Therapy for Pediatric Brain Tumors AdV-tk, valacyclovir, Radiation - Malignant Glioma, Recurrent Ependymoma | Phase 1 | Completed | Candel Therapeutics, Inc. | 8 | 2010-10-01 | 2023-08-25 |
| Microdialysis and Pharmacokinetic Study of TR-701 TR-700 (active moiety), TR-701 (pro-drug) - Healthy | Phase 1 | Completed | Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 15 | 2008-04-04 | 2019-11-15 |
Chagas Disease (2) · Adenocarcinoma (1) · Astrocytoma (1) · Bronchiolitis Obliterans Syndrome (1) · Ependymoma (1) · Glioblastoma (1) · Glioma (1) · HIV Infections (1) · Prostatic Neoplasms (1)
Candel Therapeutics, Inc. (2) · Drugs for Neglected Diseases (2) · Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (1) · ViiV Healthcare (1)
United States (4) · Bolivia (2)
Faustino Torrico, PhD (2) · Harmut Derendorf, PhD (1) · Isabela Ribeiro, MD (1)
PMID 22584101, PMID 29352704, PMID 30509941, PMID 30883662, PMID 33836161, PMID 36409773, PMID 39627222, PMID 40982532