72 completed, 16 unknown, 6 terminated, 4 recruiting. 25 Phase 3, 23 Phase 2, 14 Not applicable, 13 Phase 1, 10 Phase 4.
Follow Trypanosomiasis: new trials by email Literature Review of Trypanosomiasis trials Research Report on Trypanosomiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's Health Nifurtimox (BAYA2502) - Chagas Disease | Not yet recruiting | Bayer | 50 | 2026-12-31 | 2026-07-06 | |
| Assessment of the Risk of Zoonotic Infections in Prisons in French Guiana Q Fever, Leptospirosis | Not yet recruiting | Centre Hospitalier de Cayenne | 450 | 2026-10-01 | 2026-10-19 | |
| First-in-Human Trial of Oral AN2-502998 AN2-502998, Placebo - Healthy Volunteers | Phase 1 | Completed | AN2 Therapeutics, Inc | 72 | 2025-08-04 | 2026-04-30 |
| A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease. LXE408, Placebo, Benznidazole - Chagas Disease | Phase 2 | Recruiting | Novartis Pharmaceuticals | 130 | 2025-04-28 | 2026-11-10 |
| Short Benznidazole Regimen for Chronic Phase Chagas Disease Patients benznidazole 300 mg daily 8 weeks - Chronic Chagas Disease | Phase 3 | Withdrawn | Evandro Chagas Institute of Clinical Research | 2025-01-30 | 2025-03-13 | |
| University-Based Chagas Testing in Salta Province, Argentina Rapid diagnostic test (RDT) for Trypanosoma cruzi infection. - Chagas Disease, Trypanosoma Cruzi Infection | Completed | Mundo Sano Foundation | 2568 | 2024-09-11 | 2026-06-23 | |
| Stop Transmission of Gambiense Human African Trypanosomiasis Acoziborole - Trypanosomiasis; African, Due to Trypanosoma Brucei Gambiense, Gambiense | Phase 3 | Recruiting | Institute of Tropical Medicine, Belgium | 2500 | 2024-03-15 | 2026-08-27 |
| Delivering a Multi-disease Screening Tool to Migrant Populations Clinical decision support system for screening of migrants using the ISMiHealth software tool. - Hiv, Hepatitis B | Not applicable | Completed | Barcelona Institute for Global Health | 980 | 2024-01-01 | 2025-05-13 |
| Screen and Treat Implementation for HAT Control Screen&treat - Sleeping Sickness, Trypanosomiasis, African | Withdrawn | Institute of Tropical Medicine, Belgium | 2024-01-01 | 2024-02-02 | ||
| DDI Study of Single Oral Dose of Acoziborole With Sequential Co-administration of Midazolam and Dextromethorphan Acoziborole, Midazolam, Dextromethorphan - Trypanosomiasis, African | Phase 1 | Completed | Drugs for Neglected Diseases | 20 | 2023-02-09 | 2023-07-17 |
| Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients Acoziborole - Trypanosomiasis, African, Trypanosoma Brucei Gambiense; Infection | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 35 | 2022-07-09 | 2026-04-06 |
| Prospective Evaluation of the Specificity of Serological Tests for Human African Trypanosomiasis Serological field test for HAT, malaria rapid test, Immunologic laboratory tests - Human African Trypanosomiasis, Sleeping Sickness | Not applicable | Completed | Institut de Recherche pour le Developpement | 1095 | 2022-06-20 | 2024-04-05 |
| Cardiac Contractility Modulation in Chagas Heart Disease Cardiac Contractility Modulation (CCM), CRT - Chagas Cardiomyopathy, Heart Failure | Not applicable | Recruiting | InCor Heart Institute | 60 | 2022-05-25 | 2026-07-08 |
| Safety and Tolerability Study of Acoziborole in g-HAT Seropositive Subjects Acoziborole, Placebo - Trypanosomiasis, African, Trypanosoma Brucei Gambiense; Infection | Phase 2 / Phase 3 | Completed | Drugs for Neglected Diseases | 1208 | 2021-12-30 | 2025-03-20 |
| Atorvastatin on Inflammation and Cardiac Function in Chronic Chagas Disease 40 mg Atorvastatin/day for 120 days P.O., Atorvastatin 80, Placebo - Chronic Chagas Disease | Phase 2 | Terminated | Juan D. Maya | 300 | 2021-10-12 | 2024-09-19 |
| Shorter Benznidazole Regimens Compared to the Standard Regimen for Chagas Disease Short regimen of benznidazole, Short treatment with benznidazole, Standard treatment with benznidazole - Chagas Disease | Phase 3 | Recruiting | Laboratorio Elea Phoenix S.A. | 300 | 2021-07-28 | 2023-11-30 |
| SBRT in Chagas Disease Ventricular Tachycardia Stereotactic Body Radiation Therapy - Ventricular Tachycardia, Chagas Disease | Phase 1 / Phase 2 | Unknown | University of Sao Paulo General Hospital | 10 | 2021-07-14 | 2024-07-16 |
| Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF. Sacubitril / Valsartan Oral Tablet [Entresto], Enalapril - Chagas Cardiomyopathy | Phase 3 | Unknown | University of Sao Paulo General Hospital | 200 | 2021-05-06 | 2024-04-04 |
| Cardiac Mechanics by Speckle Tracking as a Prognostic Predictor in Patients With Chagas Cardiomyopathy Chagas Cardiomyopathy, Speckle Tracking Echocardiography | Completed | University of Sao Paulo | 153 | 2021-01-16 | 2025-02-04 | |
| ADME Study of Acoziborole in Healthy Subjects [14C]-acoziborole capsule, 240 mg containing NMT 9.25 kBq (250 nCi) 14C - Trypanosomiases, African | Phase 1 | Completed | Drugs for Neglected Diseases | 6 | 2020-02-05 | 2021-04-27 |
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Chagas Disease (73) · Trypanosomiasis, African (22) · Chagas Cardiomyopathy (17) · Heart Failure (10) · Infections (7) · Disease (5) · Heart Diseases (5) · Cardiomyopathies (4) · Tachycardia, Ventricular (4) · Arrhythmias, Cardiac (3) · Bronchiolitis Obliterans Syndrome (3) · Hypersensitivity (3) · Motor Activity (3) · Neglected Diseases (3)
Euglenozoa Infections (103) · Protozoan Infections (102) · Vector Borne Diseases (102) · Parasitic Diseases (101) · Infections (96) · Cardiovascular Diseases (28) · Heart Diseases (23) · Pathologic Processes (19) · Pathological Conditions, Signs and Symptoms (19) · Cardiomyopathies (15) · Chagas Disease (7) · Immune System Diseases (7) · Behavior (5) · Cardiac Conduction System Disease (5)
benzonidazole (19) · Nifurtimox (13) · fexinidazole (7) · Eflornithine (5) · Exercise (4) · Rapid Diagnostic Tests (3) · Amiodarone (2) · Catheter Ablation (2) · Control Groups (2) · Enalapril (2) · Granulocyte Colony-Stimulating Factor (2) · LXE408 (2) · Prodrugs (2) · SCYX 7158 (2) · posaconazole (2)
Drugs for Neglected Diseases (20) · Bayer (7) · Hospital Sao Rafael (6) · Hospital de Niños R. Gutierrez de Buenos Aires (6) · Institut de Recherche pour le Developpement (5) · University of Sao Paulo General Hospital (5) · Federal University of Minas Gerais (3) · InCor Heart Institute (3) · Novartis Pharmaceuticals (3) · Barcelona Centre for International Health Research (2) · Epicentre (2) · Evandro Chagas Institute of Clinical Research (2) · Evandro Chagas National Institute of Infectious Disease (2) · Hospital Universitari Vall d'Hebron Research Institute (2) · Immtech Pharmaceuticals, Inc (2)
Brazil (34) · Argentina (26) · Colombia (11) · Bolivia (10) · Democratic Republic of the Congo (10) · United States (8) · Spain (7) · Guinea (6) · Republic of the Congo (5) · Côte d’Ivoire (3) · France (3) · Mexico (3) · Uganda (3) · Chile (2) · El Salvador (2)
Milena Botelho Pereira Soares, PhD (3) · Antoine Tarral, MD (2) · Antonio L Ribeiro, MD, PhD (2) · Bruno SF Souza, MD, Msc (2) · Facundo Garcia Bournissen, MD PhD (2) · Faustino Torrico, PhD (2) · Gerardo Priotto, MD, MPH (2) · Isabela Ribeiro, MD (2) · Jaime Altcheh, MD (2)
PMID 16928995, PMID 26881924, PMID 29351667, PMID 30509941, PMID 34265407, PMID 7994859, PMID 8937280, PMID 9790423, PMID 10677747, PMID 10707756, PMID 11139981, PMID 11175486, PMID 11500748, PMID 12241721, PMID 12456332, PMID 12886425, PMID 12892979, PMID 13849070, PMID 15034825, PMID 15558179, PMID 15837098, PMID 15845889, PMID 16023747, PMID 16202650, PMID 16235350, PMID 16651029, PMID 16702588, PMID 17151373, PMID 17273653, PMID 17339568, PMID 17339569, PMID 17383291, PMID 17678433, PMID 17689706, PMID 17689724, PMID 17891282, PMID 18053595, PMID 18199497, PMID 18266670, PMID 18545843, PMID 19131007, PMID 19131444, PMID 19142374, PMID 19168514, PMID 19287904, PMID 19410718, PMID 19452608, PMID 19477538, PMID 19559476, PMID 19654138
2016 (2), P50AI098461 (1), R01HL066480 (1), R01NS064905 (1), U01AI129783 (1), Z01HL005264 (1)