23 completed, 6 unknown, 5 recruiting, 3 not yet recruiting. 11 Not applicable, 10 Phase 1, 6 Phase 2, 5 Phase 3, 2 Phase 4.
Follow Neglected Diseases: new trials by email Literature Review of Neglected Diseases trials Research Report on Neglected Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations Modified Mass Administration of Medicines Strategy, Albendazole 400 mg, Praziquantel 40 mg/kg - Onchocerciasis (River Blindness), Schistosomiasis | Not applicable | Recruiting | Uwemedimo Friday Ekpo | 5760 | 2026-07-01 | 2026-07-16 |
| Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers A mobile app with AI functionality for diagnosing skin-related NTDs - Skin and Connective Tissue Diseases, Neglected Tropical Diseases | Not applicable | Not yet recruiting | Kenya Medical Research Institute | 2420 | 2026-05-01 | 2026-04-02 |
| ARN-75039 Lassa Fever Treatment in West Africa ARN-75039 high, Intravenous ribavirin, ARN-75039 low - Lassa Fever | Phase 2 | Suspended | Arisan Therapeutics, Inc. | 135 | 2026-02-14 | 2026-07-06 |
| Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective Dengue, Chikungunya | Recruiting | Institut Pasteur du Cambodge | 10000 | 2025-12-18 | 2026-01-22 | |
| Prospective Evaluation of Rapid Diagnostic Tests for Trypanosoma Cruzi Infection Chronic Chagas | Recruiting | Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben | 3234 | 2025-08-29 | 2026-01-21 | |
| Ivermectin Therapy for Scabies Infection in Children Younger Than 5 Years of Age (ITCHY Study) Ivermectin Tablets - Scabies; Itch, Scabies | Phase 2 | Active not recruiting | Murdoch Childrens Research Institute | 120 | 2025-06-24 | 2026-10-16 |
| Implementation of the COmmunity HEalth System InnovatiON Project in Low- and Middle- Income Countries Co-creation (2016 to 2019) + Co-design (2023 to 2024), Co-design only (2023 to 2024) - Hypertension, Diabetes Mellitus | Not applicable | Not yet recruiting | Universidad Peruana Cayetano Heredia | 2094 | 2025-05-17 | 2025-05-25 |
| Safety, Tolerability and PK of Single and Multiple Doses of Oxantel Pamoate Tablets Oxantel Pamoate, Placebo - Healthy | Phase 1 | Completed | Swiss Tropical & Public Health Institute | 45 | 2025-01-27 | 2025-08-28 |
| Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis albendazole and praziquantel, Albendazole - Neurocysticercosis | Phase 4 | Not yet recruiting | R-Evolution Worldwide S.r.l. Impresa Sociale | 300 | 2024-06-01 | 2024-04-23 |
| Development of a New Rapid Diagnostic Test to Support Onchocerciasis Elimination Biological samples collection (blood drawing + feces) - Onchocerciasis, Loiasis | Not applicable | Completed | Bioaster | 1128 | 2024-04-15 | 2026-09-30 |
| Digital Toolkit for Skin Diseases in LMICs: Part 2 mHealth app - Skin Diseases | Not applicable | Completed | Tulane University | 1000 | 2024-03-18 | 2026-10-13 |
| Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy Metformin, Placebo - Leprosy, Leprosy, Multibacillary | Phase 2 | Recruiting | Oxford University Clinical Research Unit Indonesia | 166 | 2022-10-01 | 2025-08-07 |
| Assessment of Recombinant HAT-RDT Specificity Human African Trypanosomiasis | Completed | Institute of Tropical Medicine, Belgium | 1504 | 2022-09-20 | 2023-09-28 | |
| Evaluation of the Diagnosis Performances of DEC LTS-2 Skin Patch for Onchocerciasis in Central Africa LTS-2 DEC patch, Skin snips - Onchocerciasis, Loiasis | Not applicable | Withdrawn | Center for Research on Filariasis and Other Tropical Diseases, Cameroon | 2022-09-01 | 2025-03-25 | |
| PK, Safety and Tolerability of Single and Multiple Doses of Oxfendazole Tablets Oxfendazole, Placebo - Filariasis | Phase 1 | Completed | Swiss Tropical & Public Health Institute | 30 | 2022-04-21 | 2022-12-20 |
| Spatial Analysis of Host-parasite Interactions in Cutaneous Leishmaniasis in Ethiopia skin biopsy, venous blood sample (plasma, PBMC, WB), venous blood sample (HLA) - Cutaneous Leishmaniases | Completed | Institute of Tropical Medicine, Belgium | 92 | 2022-03-21 | 2025-01-09 | |
| Digital Toolkit for Skin Diseases in LMICs mHealth app - Skin Diseases | Not applicable | Unknown | Tulane University | 1364 | 2022-02-14 | 2022-09-27 |
| Adoption of L-PZQ for Schistosomiasis by Endemic Counties - Social Science Research Study Community pilot L-PZQ distribution - intervention is NOT part of this observational study - Schistosomiasis in Children, Social Acceptance | Unknown | Technical University of Munich | 225 | 2021-12-01 | 2023-12-01 | |
| Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy Standard [RC8]: rifampicin plus clarithromycin (RC) therapy for 8 weeks., Investigational [RCA4]: standard (RC) plus amoxicillin/clavulanate (A) for 4 weeks. - Buruli Ulcer | Phase 2 | Unknown | Fundacion Agencia Aragonesa para la Investigacion y Desarrollo (ARAID) | 140 | 2021-12-01 | 2024-05-16 |
| Emodepside Phase II Trial for Treatment of Onchocerciasis emodepside, matching placebo of emodepside, ivermectin - Onchocerciasis | Phase 2 | Unknown | Drugs for Neglected Diseases | 578 | 2021-08-30 | 2024-03-05 |
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Onchocerciasis (7) · Ancylostomiasis (6) · Elephantiasis, Filarial (6) · Parasitic Diseases (5) · Anemia, Iron-Deficiency (4) · Hookworm Infections (4) · Scabies (4) · Skin Diseases (4) · Filariasis (3) · Infections (3) · Leishmaniasis, Cutaneous (3) · Schistosomiasis (3) · Skin Diseases, Parasitic (3) · Yaws (3)
Disease Attributes (41) · Pathologic Processes (41) · Pathological Conditions, Signs and Symptoms (41) · Infections (29) · Parasitic Diseases (21) · Helminthiasis (17) · Skin and Connective Tissue Diseases (16) · Nematode Infections (15) · Secernentea Infections (15) · Skin Diseases (14) · Vector Borne Diseases (14) · Hemic and Lymphatic Diseases (12) · Skin Diseases, Infectious (12) · Bacterial Infections (10) · Bacterial Infections and Mycoses (10)
Albendazole (6) · Ivermectin (6) · Azithromycin (3) · Bay 44-4400 (2) · Praziquantel (2) · emodepside (2) · fexinidazole (2) · Blood Specimen Collection (1) · CPG-oligonucleotide (1) · Clarithromycin (1) · Clavulanic Acid (1) · Defecation (1) · Diethylcarbamazine (1) · GLA-AF adjuvant (1) · Hepatitis B Vaccines (1)
Drugs for Neglected Diseases (5) · Baylor College of Medicine (4) · Emory University (3) · Institute of Tropical Medicine, Belgium (3) · Lihir Medical Centre (2) · Swiss Tropical & Public Health Institute (2) · Tulane University (2) · Arisan Therapeutics, Inc. (1) · Bioaster (1) · Center for Research on Filariasis and Other Tropical Diseases, Cameroon (1) · Fundacion Agencia Aragonesa para la Investigacion y Desarrollo (ARAID) (1) · Hospital de Niños R. Gutierrez de Buenos Aires (1) · Institut Pasteur du Cambodge (1) · Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben (1) · Kenya Medical Research Institute (1)
Democratic Republic of the Congo (4) · United States (4) · Côte d’Ivoire (3) · Ethiopia (3) · Nigeria (3) · Argentina (2) · Cameroon (2) · France (2) · Gabon (2) · Kenya (2) · Mozambique (2) · Papua New Guinea (2) · Tanzania (2) · Uganda (2) · Australia (1)
Ayola Adegnika, MD (2) · Alain Toh, Prof. (1) · Alejandro J Krolewiecki, MD/PhD (1) · Amanda Gwee, PhD (1) · Anna R Last, MBChB PhD (1) · Antoine Tarral, MD (1) · Christian Salmon, DrSc (1) · Claude Flamand, Ph.D. (1) · Daniel Paris (1) · Daniel Paris, MD, PhD (1) · David Diemert, MD (1) · David J Diemert, MD (1) · Emmanuel Bottieau, MD (1) · Enock Matovu, Prof (1)
PMID 22240407, PMID 24853169, PMID 29346367, PMID 29988004, PMID 31226957, PMID 32439737, PMID 32926834, PMID 34597297, PMID 35804454, PMID 35922062, PMID 36763327, PMID 36962125, PMID 37024634, PMID 37419638, PMID 37632977, PMID 38573915, PMID 38808319, PMID 39109221, PMID 39551062, PMID 40288400, PMID 41121745, PMID 41351066, PMID 41475833, PMID 41662151, PMID 41705834, PMID 42104494
2015 (1)