54 completed, 16 unknown, 3 recruiting, 3 terminated. 15 Phase 2, 15 Phase 3, 10 Not applicable, 9 Phase 4, 8 Phase 1.
Follow Chagas Disease: new trials by email Literature Review of Chagas Disease trials Research Report on Chagas Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's Health Nifurtimox (BAYA2502) - Chagas Disease | Not yet recruiting | Bayer | 50 | 2026-12-31 | 2026-07-06 | |
| Assessment of the Risk of Zoonotic Infections in Prisons in French Guiana Q Fever, Leptospirosis | Not yet recruiting | Centre Hospitalier de Cayenne | 450 | 2026-10-01 | 2026-10-19 | |
| First-in-Human Trial of Oral AN2-502998 AN2-502998, Placebo - Healthy Volunteers | Phase 1 | Completed | AN2 Therapeutics, Inc | 72 | 2025-08-04 | 2026-04-30 |
| A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease. LXE408, Placebo, Benznidazole - Chagas Disease | Phase 2 | Recruiting | Novartis Pharmaceuticals | 130 | 2025-04-28 | 2026-10-15 |
| Short Benznidazole Regimen for Chronic Phase Chagas Disease Patients benznidazole 300 mg daily 8 weeks - Chronic Chagas Disease | Phase 3 | Withdrawn | Evandro Chagas Institute of Clinical Research | 2025-01-30 | 2025-03-13 | |
| University-Based Chagas Testing in Salta Province, Argentina Rapid diagnostic test (RDT) for Trypanosoma cruzi infection. - Chagas Disease, Trypanosoma Cruzi Infection | Completed | Mundo Sano Foundation | 2568 | 2024-09-11 | 2026-06-23 | |
| Delivering a Multi-disease Screening Tool to Migrant Populations Clinical decision support system for screening of migrants using the ISMiHealth software tool. - Hiv, Hepatitis B | Not applicable | Completed | Barcelona Institute for Global Health | 980 | 2024-01-01 | 2025-05-13 |
| Cardiac Contractility Modulation in Chagas Heart Disease Cardiac Contractility Modulation (CCM), CRT - Chagas Cardiomyopathy, Heart Failure | Not applicable | Recruiting | InCor Heart Institute | 60 | 2022-05-25 | 2026-07-08 |
| Atorvastatin on Inflammation and Cardiac Function in Chronic Chagas Disease 40 mg Atorvastatin/day for 120 days P.O., Atorvastatin 80, Placebo - Chronic Chagas Disease | Phase 2 | Terminated | Juan D. Maya | 300 | 2021-10-12 | 2024-09-19 |
| Shorter Benznidazole Regimens Compared to the Standard Regimen for Chagas Disease Short regimen of benznidazole, Short treatment with benznidazole, Standard treatment with benznidazole - Chagas Disease | Phase 3 | Recruiting | Laboratorio Elea Phoenix S.A. | 300 | 2021-07-28 | 2023-11-30 |
| SBRT in Chagas Disease Ventricular Tachycardia Stereotactic Body Radiation Therapy - Ventricular Tachycardia, Chagas Disease | Phase 1 / Phase 2 | Unknown | University of Sao Paulo General Hospital | 10 | 2021-07-14 | 2024-07-16 |
| Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF. Sacubitril / Valsartan Oral Tablet [Entresto], Enalapril - Chagas Cardiomyopathy | Phase 3 | Unknown | University of Sao Paulo General Hospital | 200 | 2021-05-06 | 2024-04-04 |
| Cardiac Mechanics by Speckle Tracking as a Prognostic Predictor in Patients With Chagas Cardiomyopathy Chagas Cardiomyopathy, Speckle Tracking Echocardiography | Completed | University of Sao Paulo | 153 | 2021-01-16 | 2025-02-04 | |
| New Therapies and Biomarkers for Chagas Infection Benznidazole, Nifurtimox - Trypanosoma Cruzi Infection, Chagas Disease | Phase 2 | Completed | University of Texas, El Paso | 450 | 2019-12-18 | 2024-07-17 |
| Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC Sacubitril/valsartan, Enalapril - Chagas Disease, Heart Failure | Phase 4 | Completed | Novartis Pharmaceuticals | 922 | 2019-12-10 | 2026-05-11 |
| Prospective Study of Benznidazole for Chagas' Disease Children With Chronic Indeterminate Chagas Disease Benznidazole - Chagas Disease | Phase 3 | Active not recruiting | Insud Pharma | 178 | 2019-09-19 | 2026-04-21 |
| Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases Chagas Disease, Syphilis | Unknown | Hospital de Niños R. Gutierrez de Buenos Aires | 560 | 2019-07-01 | 2023-03-01 | |
| Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits Study Nifurtimox (Lampit, BAYA2502) - Chagas' Disease | Phase 1 | Completed | Bayer | 36 | 2019-06-10 | 2020-12-30 |
| Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age Benznidazole, Placebo Oral Tablet - Chagas Disease | Phase 3 | Completed | Tulane University School of Public Health and Tropical Medicine | 87 | 2019-06-01 | 2026-04-09 |
| A First-in-human, Safety, Tolerability, and Pharmacokinetics Study of LXE408 in Healthy Subjects LXE408, Placebo, Iohexol - Visceral Leishmaniasis, Chagas Disease | Phase 1 | Completed | Novartis Pharmaceuticals | 88 | 2018-12-21 | 2026-09-09 |
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Chagas Cardiomyopathy (17) · Heart Failure (10) · Heart Diseases (5) · Cardiomyopathies (4) · Tachycardia, Ventricular (4) · Arrhythmias, Cardiac (3) · Bronchiolitis Obliterans Syndrome (3) · Motor Activity (3) · Breast Feeding (2) · Cardiomyopathy, Dilated (2) · Death, Sudden (2) · Hepatitis B (2) · Hepatitis C (2) · Inflammation (2)
Euglenozoa Infections (80) · Infections (80) · Protozoan Infections (80) · Vector Borne Diseases (80) · Parasitic Diseases (79) · Trypanosomiasis (79) · Cardiovascular Diseases (28) · Heart Diseases (23) · Cardiomyopathies (15) · Pathologic Processes (13) · Pathological Conditions, Signs and Symptoms (13) · Behavior (5) · Cardiac Conduction System Disease (5) · Immune System Diseases (4)
benzonidazole (19) · Nifurtimox (9) · Exercise (4) · Amiodarone (2) · Catheter Ablation (2) · Control Groups (2) · Enalapril (2) · Granulocyte Colony-Stimulating Factor (2) · LXE408 (2) · Prodrugs (2) · fexinidazole (2) · posaconazole (2) · sacubitril and valsartan sodium hydrate drug combination (2) · Angiotensin-Converting Enzyme Inhibitors (1) · Aspirin (1)
Bayer (7) · Drugs for Neglected Diseases (7) · Hospital Sao Rafael (6) · Hospital de Niños R. Gutierrez de Buenos Aires (6) · University of Sao Paulo General Hospital (5) · Federal University of Minas Gerais (3) · InCor Heart Institute (3) · Novartis Pharmaceuticals (3) · Barcelona Centre for International Health Research (2) · Evandro Chagas Institute of Clinical Research (2) · Evandro Chagas National Institute of Infectious Disease (2) · Hospital Universitari Vall d'Hebron Research Institute (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Tulane University School of Public Health and Tropical Medicine (2) · University of Sao Paulo (2)
Brazil (34) · Argentina (26) · Colombia (11) · Bolivia (10) · United States (8) · Spain (7) · Mexico (3) · Chile (2) · El Salvador (2) · Honduras (2) · Australia (1) · Belgium (1) · French Guiana (1) · Germany (1) · Guatemala (1)
Milena Botelho Pereira Soares, PhD (3) · Antonio L Ribeiro, MD, PhD (2) · Bruno SF Souza, MD, Msc (2) · Facundo Garcia Bournissen, MD PhD (2) · Faustino Torrico, PhD (2) · Isabela Ribeiro, MD (2) · Jaime Altcheh, MD (2) · Milena BP Soares, PhD (2)
PMID 16928995, PMID 29351667, PMID 30509941, PMID 34265407, PMID 7994859, PMID 8937280, PMID 9790423, PMID 10677747, PMID 10707756, PMID 11139981, PMID 11175486, PMID 11500748, PMID 12241721, PMID 12456332, PMID 12886425, PMID 12892979, PMID 13849070, PMID 15034825, PMID 15558179, PMID 15837098, PMID 15845889, PMID 16023747, PMID 16202650, PMID 16235350, PMID 16651029, PMID 16702588, PMID 17151373, PMID 17273653, PMID 17339568, PMID 17339569, PMID 17383291, PMID 17678433, PMID 17689706, PMID 17689724, PMID 17891282, PMID 18053595, PMID 18199497, PMID 18266670, PMID 18545843, PMID 19131007, PMID 19131444, PMID 19142374, PMID 19168514, PMID 19287904, PMID 19410718, PMID 19452608, PMID 19477538, PMID 19654138, PMID 19753454, PMID 19753491
2016 (2), P50AI098461 (1), R01HL066480 (1), R01NS064905 (1), U01AI129783 (1), Z01HL005264 (1)