11 completed, 4 unknown, 1 recruiting, 1 terminated. 6 Phase 3, 4 Not applicable, 2 Phase 4, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 3, Unknown 2, Terminated 1 |
| Not applicable | 4 | Unknown 2, Completed 1, Recruiting 1 |
| Phase 4 | 2 | Completed 2 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow Chagas Cardiomyopathy: new trials by email Literature Review of Chagas Cardiomyopathy trials Research Report on Chagas Cardiomyopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cardiac Contractility Modulation in Chagas Heart Disease Cardiac Contractility Modulation (CCM), CRT - Chagas Cardiomyopathy, Heart Failure | Not applicable | Recruiting | InCor Heart Institute | 60 | 2022-05-25 | 2026-07-08 |
| Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF. Sacubitril / Valsartan Oral Tablet [Entresto], Enalapril - Chagas Cardiomyopathy | Phase 3 | Unknown | University of Sao Paulo General Hospital | 200 | 2021-05-06 | 2024-04-04 |
| Cardiac Mechanics by Speckle Tracking as a Prognostic Predictor in Patients With Chagas Cardiomyopathy Chagas Cardiomyopathy, Speckle Tracking Echocardiography | Completed | University of Sao Paulo | 153 | 2021-01-16 | 2025-02-04 | |
| Sympathetic Denervation by Video-assisted Thoracoscopy in Control of Cardiac Arrhythmias in Patients With Chagas Disease Bilateral sympathectomy, Catheter ablation - Chagas Cardiomyopathy, Ventricular Arrythmia | Not applicable | Completed | University of Sao Paulo General Hospital | 45 | 2018-11-09 | 2026-02-10 |
| Microvascular Endothelial Function in a Cohort of Patients With the Cardiac Form of Chronic Chagas Disease. skin laser speckle contrast imaging and video-capillaroscopy - Chagas Cardiomyopathy | Completed | National Institute of Cardiology, Laranjeiras, Brazil | 70 | 2018-08-20 | 2020-08-20 | |
| A Trial Testing Amiodarone in Chagas Cardiomiopathy Amiodarone Hydrochloride, Placebo Oral Tablet - Chagas Cardiomyopathy | Phase 3 | Unknown | Fundación Cardioinfantil Instituto de Cardiología | 200 | 2017-06-12 | 2017-06-21 |
| Physical Exercise Program in Chronic Chagas Heart Disease Exercise, nutritional and pharmaceutical counceling, Nutritional and pharmaceutical counceling - Chagas Disease, Chagas Cardiomyopathy | Phase 3 | Completed | Evandro Chagas National Institute of Infectious Disease | 30 | 2015-03-01 | 2017-07-27 |
| Congenital Chagas Disease: Long Term Follow up of Treated Children. Preliminary Report or Cardiological Evaluation in Chagas Disease Treated Children Chagas Disease, Chagas Cardiomyopathy | Completed | Hospital de Niños R. Gutierrez de Buenos Aires | 120 | 2015-01-22 | 2020-04-24 | |
| Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of Death ICD implantation, amiodarone hydrochloride - Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia | Not applicable | Unknown | InCor Heart Institute | 1100 | 2014-10-06 | 2021-08-30 |
| Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease transcatheter renal denervation - Heart Failure, Heart Failure, Systolic | Not applicable | Unknown | InCor Heart Institute | 30 | 2014-03-01 | 2014-03-31 |
| Cardiac Rehabilitation in Chagas Heart Failure Exercise, nutritional and pharmaceutical counseling - Chagas Disease, Chagas Cardiomyopathy | Phase 2 / Phase 3 | Completed | Evandro Chagas National Institute of Infectious Disease | 12 | 2013-05-01 | 2015-08-05 |
| Effects of Omega-3 Supplementation on the Cytokine and Lipid Profiles in Patients With Chronic Chagas Cardiomyopathy Omega-3, Placebo Comparator - Chagas Cardiomyopathy | Early Phase 1 | Completed | Evandro Chagas Institute of Clinical Research | 40 | 2013-03-01 | 2016-09-09 |
| Exercise Training in Chagas Cardiomyopathy Exercise training - Chagas Disease, Cardiomyopathy | Phase 4 | Completed | Federal University of Minas Gerais | 37 | 2007-03-01 | 2015-08-13 |
| Cell Therapy in Chagas Cardiomyopathy Stem cell, Filgrastime (G-CSF), Standart therapy - Chagas Cardiomyopathy | Phase 3 | Terminated | Ministry of Health, Brazil | 182 | 2006-01-01 | 2017-03-13 |
| Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity Bisoprolol - Chagas Cardiomyopathy, Chronic Heart Failure | Phase 3 | Completed | Fundación Cardiovascular de Colombia | 500 | 2003-07-01 | 2010-11-24 |
| A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy RASi plus carvedilol - Chagas Cardiomyopathy, Heart Failure | Phase 4 | Completed | Federal University of Minas Gerais | 42 | 2003-05-01 | 2015-08-13 |
| The Signal-averaged ElectrocArdiogram in Long Term Follow-up of Chronic CHagas Disease - RIO de Janeiro Cohort Chagas Cardiomyopathy, Cardiac Arrhythmia | Completed | Universidade Gama Filho | 100 | 1995-06-01 | 2013-12-10 |
Chagas Disease (10) · Heart Failure (6) · Cardiomyopathies (2) · Cardiomyopathy, Dilated (2) · Tachycardia, Ventricular (2) · Arrhythmias, Cardiac (1) · Atrial Fibrillation (1) · Bundle-Branch Block (1) · Death (1) · Death, Sudden (1) · Death, Sudden, Cardiac (1) · Heart Failure, Systolic (1) · Motor Activity (1) · Stroke (1)
Cardiovascular Diseases (17) · Euglenozoa Infections (17) · Heart Diseases (17) · Infections (17) · Parasitic Diseases (17) · Protozoan Infections (17) · Trypanosomiasis (17) · Vector Borne Diseases (17) · Cardiomyopathies (15) · Chagas Disease (7) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Cardiac Conduction System Disease (3) · Arrhythmias, Cardiac (2) · Cardiomegaly (2)
Exercise (3) · Amiodarone (2) · Angiotensin-Converting Enzyme Inhibitors (1) · Bisoprolol (1) · Carvedilol (1) · Catheter Ablation (1) · Clinical Trials as Topic (1) · Control Groups (1) · Corn Oil (1) · Docosahexaenoic Acids (1) · Double-Blind Method (1) · Enalapril (1) · Fatty Acids, Omega-3 (1) · Fatty Acids, Unsaturated (1) · Fish Oils (1)
InCor Heart Institute (3) · Evandro Chagas National Institute of Infectious Disease (2) · Federal University of Minas Gerais (2) · University of Sao Paulo General Hospital (2) · Evandro Chagas Institute of Clinical Research (1) · Fundación Cardioinfantil Instituto de Cardiología (1) · Fundación Cardiovascular de Colombia (1) · Hospital de Niños R. Gutierrez de Buenos Aires (1) · Ministry of Health, Brazil (1) · National Institute of Cardiology, Laranjeiras, Brazil (1) · Universidade Gama Filho (1) · University of Sao Paulo (1)
Brazil (14) · Colombia (2) · Argentina (1) · United States (1)
Andrea S Sousa, MD PhD (1) · Andrea S Sousa, PhD (1) · Antonio L Ribeiro, MD, PhD (1) · Carlos A Morillo, MD, FRCPC (1) · Diego A Rodriguez, MD (1) · Fernanda Mendes, M.D. (1) · Fernando A Botoni, MD, PhD (1) · Gilson Feitosa, MD (1) · Juan C Villar, MD, MSc, PhD (1) · Martino Martinelli, Prof. (1) · Paulo M Pego Fernandes, MD, PhD (1)
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