7 completed, 6 unknown, 5 recruiting, 4 terminated. 10 Not applicable, 4 Phase 3, 3 Phase 4, 2 Phase 2, 1 Early Phase 1.
Follow Treatment-resistant Schizophrenia: new trials by email Literature Review of Treatment-resistant Schizophrenia trials Research Report on Treatment-resistant Schizophrenia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low-Intensity Focused Ultrasound Neuromodulation of the Mediodorsal Thalamus for Treatment-Resistant Schizophrenia Insightec Exablate Neuro MR-guided focused ultrasound transducer - Treatment-resistant Schizophrenia | Not applicable | Suspended | NYU Langone Health | 3 | 2027-06-01 | 2026-04-02 |
| Time Course of Clozapine-associated Agranulocytosis Over 19 Years Agranulocytosis, Neutropenia | Completed | Sheba Medical Center | 2020 | 2026-09-10 | 2026-11-03 | |
| Sequential Treatment Approaches for Treatment-Resistant Schizophrenia [Phase 1] Clozapine, [Phase 1] Aripiprazole, [Phase 1] Amisulpride - Treatment-resistant Schizophrenia | Phase 3 | Recruiting | Shanghai Mental Health Center | 300 | 2026-09-01 | 2026-11-05 |
| Efficacy and Safety of Temporal Interference Stimulation in Treatment-Resistant Schizophrenia: An Exploratory Study. Temporal Interference Stimulation - Treatment-resistant Schizophrenia | Not applicable | Not yet recruiting | Zhimin Wang | 20 | 2026-08-01 | 2026-08-19 |
| Evenamide, a Glutamate Release Modulator, as Add-On to Standard of Care in Subjects With Documented Treatment-Resistant Schizophrenia Evenamide 15 mg bid, Placebo - Treatment-resistant Schizophrenia | Phase 3 | Recruiting | Newron Pharmaceuticals SPA | 400 | 2026-01-23 | 2026-09-10 |
| Cognitive Behavioral Therapy for Sleep and Circadian Disturbances (CBT-I) in Treatment-Resistant Schizophrenia CBT-I, CBT - Treatment-refractory Schizophrenia, Treatment-resistant Schizophrenia | Not applicable | Recruiting | Jimmi Nielsen | 60 | 2024-11-28 | 2026-01-20 |
| The Characteristics of Treatment Resistant Schizophrenia From the Illness Onset risperidone, olanzapine, aripiprazole - Treatment-resistant Schizophrenia | Unknown | Peking University | 300 | 2023-12-01 | 2023-11-13 | |
| Multidisciplinary Design to Optimize Schizophrenia Treatment Based on Multi-omics Data and Systems Biology Analysis Aripiprazole, Paliperidone - Schizophrenia, Treatment-resistant Schizophrenia | Phase 4 | Unknown | Consorcio Centro de Investigación Biomédica en Red (CIBER) | 244 | 2023-11-01 | 2023-09-29 |
| Deep Brain Stimulation Recovery in Treatment-Resistant Schizophrenia On-Stimulation, Off-Stimulation - Treatment-resistant Schizophrenia, Deep Brain Stimulation | Not applicable | Active not recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 6 | 2023-09-01 | 2025-07-29 |
| An Exploratory Analysis of Immune and Inflammatory Response Associated With Clozapine Clozapine, Antipsychotics,Other (non-Clozapine) - Treatment-resistant Schizophrenia | Phase 4 | Terminated | Ohio State University | 5 | 2023-08-16 | 2026-02-25 |
| Deep Brain Stimulation in Treatment Resistant Schizophrenia Medtronic Percept with SensSight Deep Brain Stimulation System - Treatment-resistant Schizophrenia | Not applicable | Terminated | Johns Hopkins University | 15 | 2023-03-01 | 2026-05-14 |
| The Role of Glutamatergic Function in the Pathophysiology of Treatment-resistant Schizophrenia Riluzole - Treatment-resistant Schizophrenia, Treatment-responsive Schizophrenia | Early Phase 1 | Unknown | King's College London | 288 | 2022-11-14 | 2024-03-05 |
| Hippocampus DBS in Treatment-resistant Schizophrenia On-Stimulation, Off-Stimulation - Treatment-resistant Schizophrenia | Not applicable | Unknown | Shanghai Mental Health Center | 6 | 2022-11-01 | 2023-01-23 |
| Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations stg-rt-fMRI-Neurofeeback, sham-rt-fMRI-Neurofeedback - Schizophrenia, Auditory Hallucination | Not applicable | Recruiting | Boston VA Research Institute, Inc. | 104 | 2022-03-01 | 2025-09-18 |
| SMART Design to Compare Antipsychotic Treatments in Treatment-Resistant Schizophrenia Clozapine, MECT, DBS - Treatment-resistant Schizophrenia | Phase 3 | Unknown | Shanghai Mental Health Center | 162 | 2020-12-01 | 2020-08-27 |
| Dundrum Forensic Redevelopment Evaluation Study: D-FOREST Study. Schizophrenia, Forensic Psychiatry | Recruiting | Health Service Executive, Ireland | 350 | 2019-12-01 | 2021-10-12 | |
| Rituximab for Schizophrenia Spectrum Disorder (RITS-PS-2019) Rituximab - Schizophrenia Spectrum and Other Psychotic Disorders, Treatment-resistant Schizophrenia | Phase 2 | Completed | Region Örebro County | 9 | 2019-08-07 | 2025-03-21 |
| Comparaison of Avatar Therapy to Cognitive Behavioral Therapy in Schizophrenia With Treatment Refractory Hallucinations Avatar Therapy, Cognitive Behavioral Therapy - Auditory Hallucination, Verbal, Treatment-resistant Schizophrenia | Not applicable | Unknown | Ciusss de L'Est de l'Île de Montréal | 136 | 2019-04-01 | 2024-02-06 |
| Telmisartan Pilot Study on Treatment Resistant Schizophrenia Telmisartan Pill - Schizophrenia, Schizo Affective Disorder | Phase 2 | Terminated | Xiaoduo Fan | 6 | 2019-02-01 | 2022-03-02 |
| Neural Biomarkers of Clozapine Response Schizophrenia, Treatment-resistant Schizophrenia | Completed | University of Pittsburgh | 41 | 2017-09-01 | 2025-03-06 |
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Schizophrenia, Treatment-Resistant (25) · Schizophrenia (13) · Hallucinations (4) · Psychotic Disorders (4) · Neutropenia (2) · Sleep Initiation and Maintenance Disorders (2) · Adenoviridae Infections (1) · Agranulocytosis (1) · Anxiety Disorders (1) · Arrhythmias, Cardiac (1) · Autistic Disorder (1) · Bipolar Disorder (1) · Bradycardia (1) · Cardiovascular Diseases (1) · Central Nervous System Infections (1)
Mental Disorders (25) · Schizophrenia Spectrum and Other Psychotic Disorders (24) · Schizophrenia (12) · Nervous System Diseases (6) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Neurologic Manifestations (5) · Neurobehavioral Manifestations (4) · Perceptual Disorders (4) · Endocrine System Diseases (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Cytopenia (2) · Dyssomnias (2) · Glucose Metabolism Disorders (2)
Aripiprazole (4) · Clozapine (4) · Cognitive Behavioral Therapy (3) · Risperidone (3) · Lurasidone Hydrochloride (2) · Olanzapine (2) · Paliperidone Palmitate (2) · ziprasidone (2) · Alfentanil (1) · Amikacin (1) · Aminocaproic Acid (1) · Amisulpride (1) · Antipsychotic Agents (1) · BID protein, human (1) · Bosentan (1)
Ciusss de L'Est de l'Île de Montréal (3) · Shanghai Mental Health Center (3) · Boston VA Research Institute, Inc. (1) · Consorcio Centro de Investigación Biomédica en Red (CIBER) (1) · Daniel Benjamin (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · H. Lundbeck A/S (1) · Health Service Executive, Ireland (1) · Jimmi Nielsen (1) · Johns Hopkins University (1) · King's College London (1) · NYU Langone Health (1) · National Health Research Institutes, Taiwan (1) · Newron Pharmaceuticals SPA (1) · Ohio State University (1)
United States (9) · Canada (4) · China (3) · United Kingdom (3) · Israel (2) · Argentina (1) · Bulgaria (1) · Denmark (1) · India (1) · Ireland (1) · Japan (1) · Malaysia (1) · Russia (1) · Singapore (1) · Spain (1)
Alexandre Dumais, MD, Ph.D (2) · Alexandre Dumais, MD, PhD (1) · Alon Mogliner, MD, PhD (1) · Chi Hornik, PharmD (1) · DengTang Liu (1) · Dengtang Liu (1) · Dengtang Liu, MD (1) · Iluminada Corripio, PhD (1) · Javier Labad Arias, MD, PhD (1) · Jimmi Nielsen, MD (1) · Mary Davoren, M.D. (1) · Nicola Cascella (1) · Oliver D Howes (1) · Ravi Anand, MD (1)
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