16 completed, 11 recruiting, 11 unknown, 4 terminated. 26 Not applicable, 7 Phase 4, 6 Phase 2, 5 Phase 3, 1 Early Phase 1.
Follow Schizophrenia, Treatment-Resistant: new trials by email Literature Review of Schizophrenia, Treatment-Resistant trials Research Report on Schizophrenia, Treatment-Resistant
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low-Intensity Focused Ultrasound Neuromodulation of the Mediodorsal Thalamus for Treatment-Resistant Schizophrenia Insightec Exablate Neuro MR-guided focused ultrasound transducer - Treatment-resistant Schizophrenia | Not applicable | Suspended | NYU Langone Health | 3 | 2027-06-01 | 2026-04-02 |
| Efficacy and Safety of Temporal Interference Stimulation in Treatment-Resistant Schizophrenia: An Exploratory Study. Temporal Interference Stimulation - Treatment-resistant Schizophrenia | Not applicable | Not yet recruiting | Zhimin Wang | 20 | 2026-08-01 | 2026-08-19 |
| Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia Aerobic Exercise, Stretching/Education Control, Active tDCS - Schizophrenia, Treatment Resistant Schizophrenia | Not applicable | Not yet recruiting | Kit Wa Chan | 160 | 2026-02-23 | 2026-02-11 |
| Evenamide, a Glutamate Release Modulator, as Add-On to Standard of Care in Subjects With Documented Treatment-Resistant Schizophrenia Evenamide 15 mg bid, Placebo - Treatment-resistant Schizophrenia | Phase 3 | Recruiting | Newron Pharmaceuticals SPA | 400 | 2026-01-23 | 2026-09-10 |
| Deep Brain Stimulation of the Nucleus Accumbens and Anterior Limb of the Internal Capsule in the Treatment of Refractory Schizophrenia Deep Brain Stimulation - Refractory Schizophrenia | Not applicable | Not yet recruiting | First Affiliated Hospital of Fujian Medical University | 10 | 2026-01-20 | 2026-01-27 |
| Effects of Nitraria Retusa Infusion on Clozapine-induced Metabolic Side Effects The Nitraria retusa arm - Treatment Resistant Schizophrenia, Obesity & Overweight | Not applicable | Recruiting | Faculty of Medicine, Sousse | 30 | 2026-01-03 | 2026-09-14 |
| Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. Group A: (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol,anxiolytics: clonazepam, stedon, tavor antidepressants: seropram),, Group B (Pharmacotherapy and TAU) (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, antidepressants,, Group C (Pharmacotherapy and Psychotherapy) Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, lithium, depakine - Treatment Resistant Schizophrenia, Treatment Resistant Bipolar Disorder | Phase 4 | Active not recruiting | Dr. Stavroula Rakitzi | 84 | 2025-06-04 | 2026-05-01 |
| Magnetic Seizure Therapy for Schizophrenia - Trial Magnetic Seizure Therapy (MST), Electroconvulsive Therapy (ECT) - Treatment Resistant Schizophrenia, Schizophrenia | Not applicable | Recruiting | Centre for Addiction and Mental Health | 80 | 2025-04-22 | 2026-02-03 |
| Maintenance ElectroConvulsive Therapy in Clozapine RESISTant Schizophrenia - the MECT-RESIST Trial maintenance electroconvulsive therapy (mECT) - Schizophrenia, Treatment Resistant Schizophrenia | Not applicable | Recruiting | Central Institute of Mental Health, Mannheim | 140 | 2025-02-14 | 2026-02-03 |
| Cognitive Behavioral Therapy for Sleep and Circadian Disturbances (CBT-I) in Treatment-Resistant Schizophrenia CBT-I, CBT - Treatment-refractory Schizophrenia, Treatment-resistant Schizophrenia | Not applicable | Recruiting | Jimmi Nielsen | 60 | 2024-11-28 | 2026-01-20 |
| Reduction of Auditory-Verbal Hallucinations in Schizophrenia Through Cortical Neuromodulation Active Transcranial Magnetic Stimulation (TMS), Sham Transcranial Magnetic Stimulation (TMS) - Treatment Resistant Schizophrenia | Not applicable | Recruiting | Centre Hospitalier St Anne | 20 | 2024-05-21 | 2026-09-21 |
| Deep Brain Stimulation for Psychosis Abbott Laboratories Infinity™ implantable deep brain stimulation system - Treatment-Refractory Schizophrenia | Not applicable | Recruiting | Bradley Lega | 10 | 2024-04-03 | 2026-06-09 |
| The Characteristics of Treatment Resistant Schizophrenia From the Illness Onset risperidone, olanzapine, aripiprazole - Treatment-resistant Schizophrenia | Unknown | Peking University | 300 | 2023-12-01 | 2023-11-13 | |
| An Open-Label, Single-Arm Clinical Trial Evaluating the Safety and Efficacy of Amisulpride in Treating Patients With Schizophrenia and Schizoaffective Disorder Who Have Treatment-Resistant Positive Symptoms Amisulpride 50 MG - Schizophrenia, Treatment-Resistant | Not applicable | Withdrawn | University of California, Los Angeles | 2023-11-01 | 2024-06-24 | |
| Multidisciplinary Design to Optimize Schizophrenia Treatment Based on Multi-omics Data and Systems Biology Analysis Aripiprazole, Paliperidone - Schizophrenia, Treatment-resistant Schizophrenia | Phase 4 | Unknown | Consorcio Centro de Investigación Biomédica en Red (CIBER) | 244 | 2023-11-01 | 2023-09-29 |
| Deep Brain Stimulation Recovery in Treatment-Resistant Schizophrenia On-Stimulation, Off-Stimulation - Treatment-resistant Schizophrenia, Deep Brain Stimulation | Not applicable | Active not recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 6 | 2023-09-01 | 2025-07-29 |
| Dextromethorphan as an Augmentation Agent in Treatment-resistant Schizophrenia Dextromethorphan, Placebo - Treatment Resistant Schizophrenia | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 40 | 2023-08-31 | 2025-05-09 |
| An Exploratory Analysis of Immune and Inflammatory Response Associated With Clozapine Clozapine, Antipsychotics,Other (non-Clozapine) - Treatment-resistant Schizophrenia | Phase 4 | Terminated | Ohio State University | 5 | 2023-08-16 | 2026-02-25 |
| Effect of Atenolol Versus Ivabradine on HRV in TRS Patients on Clozapine With Tachycardia: A Randomised Control Trial. Atenolol 25 mg, Ivabradine 10mg - Treatment Resistant Schizophrenia, Clozapine Adverse Reaction | Not applicable | Unknown | All India Institute of Medical Sciences, Bhubaneswar | 40 | 2023-08-01 | 2024-07-17 |
| Deep Brain Stimulation in Treatment Resistant Schizophrenia Medtronic Percept with SensSight Deep Brain Stimulation System - Treatment-resistant Schizophrenia | Not applicable | Terminated | Johns Hopkins University | 15 | 2023-03-01 | 2026-05-14 |
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Schizophrenia (27) · Psychotic Disorders (8) · Hallucinations (7) · Obesity (2) · Sialorrhea (2) · Sleep Initiation and Maintenance Disorders (2) · Adenoviridae Infections (1) · Anxiety Disorders (1) · Arrhythmias, Cardiac (1) · Autistic Disorder (1) · Bipolar Disorder (1) · Bradycardia (1) · Cardiovascular Diseases (1) · Central Nervous System Infections (1)
Mental Disorders (49) · Schizophrenia Spectrum and Other Psychotic Disorders (48) · Schizophrenia (22) · Pathological Conditions, Signs and Symptoms (13) · Signs and Symptoms (12) · Nervous System Diseases (10) · Neurologic Manifestations (9) · Neurobehavioral Manifestations (7) · Perceptual Disorders (7) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4) · Body Weight (3) · Endocrine System Diseases (3) · Glucose Metabolism Disorders (3) · Pathologic Processes (3)
Clozapine (6) · Aripiprazole (4) · Risperidone (4) · Cognitive Behavioral Therapy (3) · Olanzapine (3) · Paliperidone Palmitate (3) · Drug Therapy (2) · Lurasidone Hydrochloride (2) · Transcranial Magnetic Stimulation (2) · ziprasidone (2) · Alfentanil (1) · Amikacin (1) · Aminocaproic Acid (1) · Amisulpride (1) · Antidepressive Agents (1)
All India Institute of Medical Sciences, Bhubaneswar (3) · Centre for Addiction and Mental Health (3) · Ciusss de L'Est de l'Île de Montréal (3) · Shanghai Mental Health Center (3) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · University of Sao Paulo (2) · Azur Pharma, Inc (1) · Boston VA Research Institute, Inc. (1) · Bradley Lega (1) · Central Institute of Mental Health, Mannheim (1) · Centre Hospitalier St Anne (1) · Centre hospitalier de Ville-Evrard, France (1) · Consorcio Centro de Investigación Biomédica en Red (CIBER) (1) · Daniel Benjamin (1) · Dr. Stavroula Rakitzi (1)
United States (12) · Canada (7) · China (4) · India (4) · United Kingdom (4) · Brazil (3) · France (2) · Greece (2) · Spain (2) · Taiwan (2) · Argentina (1) · Bulgaria (1) · Denmark (1) · Germany (1) · Hong Kong (1)
Alexandre Dumais, MD, Ph.D (2) · Alexander Sartorius, Prof (1) · Alexandre Dumais, MD, PhD (1) · Alon Mogliner, MD, PhD (1) · Biswa Ranjan Mishra, MD (1) · Bradley Lega, M.D. (1) · Carol Tamminga, M.D. (1) · Chi Hornik, PharmD (1) · Daniel Blumberger, M.D., MSc. (1) · Danilo Jesus, Psychiatrist (1) · David McDonagh, M.D. (1) · Dengtang Liu (1) · Dengtang Liu, MD (1) · Dr. Polyxeni Georgila, M. D. (1)
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