11 recruiting, 10 completed, 7 not yet recruiting, 4 active not recruiting. 22 Not applicable, 4 Phase 4, 1 Phase 1, 1 Phase 2.
Follow Total Knee Anthroplasty: new trials by email Literature Review of Total Knee Anthroplasty trials Research Report on Total Knee Anthroplasty
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ultrasound Guided Combined Adductor Canal, Superior Genicular Nerves and Anterior Femoral Cutaneous Nerves Blocks in Comparison With Periarticular Local Anesthesia Infiltration in Primary Total Knee Arthroplasty Periarticular Infiltration, Ultrasound-Guided Triple Block Technique - Total Knee Anthroplasty | Not applicable | Recruiting | SAMEH ELSHERBINI | 112 | 2026-10-20 | 2026-11-12 |
| Smart Knee Evaluation of Exparel and Zynrelef in TKA Recovery Intra-articular injection of bupivacaine in the knee joint, intra-articular injection of Exparel in the knee joint, Zynrelef - Total Knee Anthroplasty | Phase 4 | Not yet recruiting | Foundation for Orthopaedic Research and Education | 200 | 2026-10-15 | 2026-10-16 |
| Assessment of the Nutritional Status of Patients Undergoing Prosthetic Orthopedic Surgery: An Exploratory Study Blood and physical performance tests - Total Knee Anthroplasty | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 60 | 2026-09-01 | 2026-08-24 |
| Evaluation of Choose to Move Replacement Ready (CTM-RR) Choose to Move Replacement Ready - Osteoarthritis (OA), Osteoarthritis (OA) of the Hip | Not applicable | Recruiting | University of British Columbia | 210 | 2026-09-01 | 2026-08-24 |
| Impact of Chronic Venous Insufficiency on Outcomes After Total Knee Arthroplasty Total Knee Anthroplasty, Venous Insufficiency (Chronic)(Peripheral) | Active not recruiting | SB Istanbul Education and Research Hospital | 100 | 2026-06-30 | 2026-10-15 | |
| Investigation of the Individual Fatigue Response During Blood Flow Restriction Training Cycling BFR - Total Knee Anthroplasty | Not applicable | Completed | University Hospital, Bonn | 15 | 2026-06-26 | 2026-10-23 |
| Tourniquet Vs. No-Tourniquet Technique in Total Knee Arthroplasty at the University Hospital of the West Indies pneumatic tourniquet - Knee Osteoarthritis (OA), Total Knee Anthroplasty | Not applicable | Not yet recruiting | The University of The West Indies | 30 | 2026-06-01 | 2026-04-01 |
| Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Postoperative Analgesia After Total Knee Arthroplasty Programmed intermittent epidural bolus 6 ml, continuous epidural infusion - Total Knee Anthroplasty, Epidural Analgesia | Not applicable | Not yet recruiting | Sakarya University | 90 | 2026-06-01 | 2026-05-28 |
| "The Effect of AI-Assisted Mobilization Education on Kinesiophobia and Readiness for Hospital Discharge in Patients Undergoing Total Knee Arthroplasty'' Artificial intelligence-assisted mobilization education video - Total Knee Anthroplasty | Not applicable | Recruiting | Kocaeli University | 72 | 2026-05-05 | 2026-07-10 |
| Liposomal Bupivacaine Versus Ropivacaine With Perineural Dexamethasone or Dexmedetomidine as Adjuncts for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty Liposomal bupivacaine (LB), Ropivacaine with Perineural Dexamethasone, Ropivacaine with Perineural Dexmedetomidine - Total Knee Anthroplasty, Nerve Block | Not applicable | Completed | Huazhong University of Science and Technology | 90 | 2026-04-09 | 2026-10-06 |
| Proximal Spread in Adductor Canal Block(ACB) Comparison of Proximal Adductor Canal Block, Comparison True Distal Adductor Canal Block. - Total Knee Anthroplasty, Postoperative Pain | Not applicable | Active not recruiting | Ankara Etlik City Hospital | 68 | 2026-04-07 | 2026-05-19 |
| Using a Smart Implantable Device to Compare Early Recovery in Two Different Knee Arthroplasty Approaches Total Knee Arthroplasty Medial Parapatellar Approach, Total Knee Arthroplasty Subvastus Approach - Total Knee Anthroplasty | Not applicable | Enrolling by invitation | Total Joint Specialists | 110 | 2026-02-11 | 2026-10-09 |
| Effect of Combined Adductor Canal and AFCN Block on Postoperative Inflammation Total Knee Anthroplasty | Active not recruiting | Fatih Sultan Mehmet Training and Research Hospital | 60 | 2026-01-19 | 2026-04-07 | |
| Knee Flexionater to Avoid Motion Restoring Surgery Hydraulic high Intensity Stretch Device, Standard Physical Therapy - Joint Contractures, Total Knee Anthroplasty | Not applicable | Recruiting | Ermi LLC | 150 | 2025-12-09 | 2026-03-06 |
| The Effects of Mir Shakeel Teleintegrated Therapy Plan in Patients Undergoing Total Knee Arthroplasty Mir Shakeel Teleintegrated Therapy plan, Conventional Physical Therapy - Total Knee Anthroplasty, Total Knee Arthroplasty Recovery | Not applicable | Recruiting | Lincoln University College Malaysia | 150 | 2025-11-30 | 2026-07-07 |
| Prospective, In-Vivo, Post-Market Safety and Efficacy Surveillance Registry of the MAXX Orthopedics, Freedom Total Knee® System Total Knee Arthroplasty - Knee Osteoarthristis, Total Knee Anthroplasty | Recruiting | Maxx Orthopedics Inc | 300 | 2025-11-01 | 2026-06-26 | |
| Monocentric Randomised Controlled Trial Assessing Cryocompression Following Total Knee Replacement Cryotherapy, Game Ready - Total Knee Anthroplasty, Cryotherapy | Not applicable | Recruiting | Clinique des Cèdres | 138 | 2025-10-27 | 2026-01-26 |
| Dinalbuphine Sebacate in Postoperative Pain Control After TKA Dinalbuphine Sebacate, Normal Saline - Osteo Arthritis of the Knee, Total Knee Anthroplasty | Phase 4 | Not yet recruiting | Thammasat University | 100 | 2025-10-01 | 2025-08-24 |
| Comparison of Ultrasound-Guided Lumbar ESPB and ACB for Knee Arthroplasty Postoperative analgesia management - Total Knee Anthroplasty | Not applicable | Completed | Bursa City Hospital | 60 | 2025-08-15 | 2026-10-02 |
| The Sacral Erector Spinae Plane Block in Total Knee Arthroplasty Local Anesthetic Injection - Total Knee Anthroplasty, Regional Anesthesia | Recruiting | San Giovanni di Dio Hospital | 126 | 2025-07-16 | 2025-08-28 |
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Osteoarthritis (4) · Pain (4) · Pain, Postoperative (4) · Osteoarthritis, Knee (3) · Bites and Stings (1) · Edema (1) · Hemorrhage (1) · Kinesiophobia (1) · Mobility Limitation (1) · Motor Activity (1) · Sedentary Behavior (1) · Shoulder Pain (1) · Social Isolation (1) · Venous Insufficiency (1) · Wounds and Injuries (1)
Pathological Conditions, Signs and Symptoms (9) · Joint Diseases (8) · Musculoskeletal Diseases (8) · Neurologic Manifestations (8) · Signs and Symptoms (8) · Arthritis (7) · Rheumatic Diseases (7) · Pathologic Processes (5) · Pain (4) · Postoperative Complications (4) · Osteoarthritis (3) · Anxiety Disorders (1) · Arthralgia (1) · Behavior (1) · Cardiovascular Diseases (1)
Arthroplasty, Replacement, Knee (2) · Bupivacaine (2) · Epinephrine (2) · Acetaminophen (1) · Adrenal Cortex Hormones (1) · Anesthesia, General (1) · Anesthesia, Spinal (1) · Anesthetics, Local (1) · Blood Specimen Collection (1) · Cryotherapy (1) · Methylprednisolone (1) · Morphine (1) · Passive Cutaneous Anaphylaxis (1) · Ropivacaine (1) · Saline Solution (1)
Ankara Etlik City Hospital (2) · Bursa City Hospital (2) · Ankara City Hospital Bilkent (1) · Assiut University (1) · Ataturk University (1) · Clinique des Cèdres (1) · Dr. Renate List (1) · Ermi LLC (1) · Fatih Sultan Mehmet Training and Research Hospital (1) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · Foundation for Orthopaedic Research and Education (1) · GCS Ramsay Santé pour l'Enseignement et la Recherche (1) · Haseki Training and Research Hospital (1) · Huazhong University of Science and Technology (1) · King Abdullah International Medical Research Center (1)
Turkey (Türkiye) (12) · United States (4) · Canada (2) · China (2) · France (2) · Italy (2) · Saudi Arabia (2) · Thailand (2) · Germany (1) · Jamaica (1) · Pakistan (1) · Switzerland (1)
Amir Khoshbin, MD, FRCS (C) (1) · Asit Shah, MD, PhD (1) · Dr. Mir Shakeel Ahmad (1) · Heather A McKay, PhD (1) · Joanie Sims Gould, MSW, PhD (1) · Laura Churchill, PT, PhD (1) · Maxim Christmas, DM (Orthopaedics), FACS, FCCS (1) · Mustafa Azizoglu, Associated Professor (1) · Prof Dr. Chua Siew Kuan (1) · Semih Baskan, Proffesor (1) · Shaun K Stinton, PhD (1) · Sohibe A Ghietah, Specialist (1) · Steven Lyons, MD (1)
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