49 completed, 10 unknown, 4 not yet recruiting, 4 withdrawn. 69 Phase 2, 14 Phase 3, 9 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 69 | Completed 49, Unknown 10, Not yet recruiting 4, Withdrawn 4, Terminated 2 |
| Phase 3 | 14 | Completed 10, Unknown 3, Not yet recruiting 1 |
| Phase 1 | 9 | Completed 7, Unknown 2 |
Follow Tooth Demineralization: new trials by email Literature Review of Tooth Demineralization trials Research Report on Tooth Demineralization
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Study of KH001 for Pulp Preservation and Safety in Deep Dentin Caries KH001, Placebo - Dental Caries | Phase 2 | Not yet recruiting | Seoul National University Dental Hospital | 36 | 2026-09-30 | 2026-08-06 |
| Gluma Compared With Bonding Agent for Post-operative Sensitivity Following Composite Restorations Drug/Agent: Gluma Desensitizer, Drug/Agent: No desensitizer (Control) - Post-operative Sensitivity, Dentin Hypersensitivity | Phase 2 / Phase 3 | Not yet recruiting | Beenish Hassan | 60 | 2025-12-01 | 2025-09-23 |
| Effect Of Three Remineralizing Agents On Early Childhood Caries Silver Diamine Fluoride (SDF, 38%), Sodium Fluoride with CPP-ACP, Acidulated phospahate fluoride gel 1.23% - Early Childhood Caries (ECC), Dental Caries | Phase 2 | Completed | University of Jazan | 90 | 2025-11-01 | 2026-09-10 |
| Clinical and Radiographic Evaluation of Indirect Pulp Capping Using Platelet Rich Fibrin Versus Mineral Trioxide Aggregate in Deep Carious Molars: a Randomized Controlled Trial MTA, PRF - Dental Caries, Pulp Caping | Phase 2 | Not yet recruiting | Cairo University | 50 | 2025-06-01 | 2025-03-21 |
| Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries Silver diamine fluoride- potassium iodide, Fluoride varnish, 0.9 % saline - Demineralization, Tooth, White Spot Lesion of Tooth | Phase 2 | Not yet recruiting | National University of Malaysia | 99 | 2025-01-31 | 2025-01-30 |
| Evaluation of Silver Diamine Fluoride, Sodium Fluoride With Casein Phosphopeptide-Amorphous Calcium Phosphate(MI Varnish) and Dycal to Arrest Caries When Used in Indirect Pulp Capping Procedures in Children Silver Diamine Fluoride (SDF, 38%) gel, Sodium Fluoride with CPP-ACP (MI varnish), Calcium Hydroxide (CH) - Early Childhood Caries (ECC), Color Stability of Restoration | Phase 2 | Completed | University of Jazan | 90 | 2024-05-06 | 2026-10-26 |
| TheraCal PT vs. Formocresol in Primary Molar Pulpotomies Dual cured resin modified - Reversible Pulpitis | Phase 1 / Phase 2 | Completed | Hama University | 50 | 2024-01-01 | 2026-10-07 |
| A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children 0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice - Dental Caries | Phase 2 | Completed | Colgate Palmolive | 2025 | 2021-01-21 | 2026-07-21 |
| Preventing Early Childhood Caries With Silver Diamine Fluoride silver diamine fluoride, sodium fluoride - Dental Caries | Phase 2 | Unknown | The University of Hong Kong | 730 | 2020-10-27 | 2022-12-09 |
| Preventing Caries with Silver Diamine Fluoride SDF, NaF - Dental Caries | Phase 2 | Completed | The University of Hong Kong | 688 | 2020-10-22 | 2024-09-25 |
| Remineralization Efficacy of Gum Arabic Varnish. Gum Arabic varnish, Proflourid Varnish,VOCO, MI Varnish,GC Japan Inc. - Caries,Dental, Remineralization | Phase 2 / Phase 3 | Unknown | Cairo University | 90 | 2020-10-01 | 2020-07-13 |
| Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General Kovanaze Nasal Spray, Articaine Injection - Caries,Dental, Apical Periodontitis | Phase 2 | Withdrawn | Virginia Commonwealth University | 2020-09-01 | 2024-10-15 | |
| Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Endodontics Kovanaze Nasal Spray, Articaine Injection - Caries,Dental, Apical Periodontitis | Phase 2 | Withdrawn | Virginia Commonwealth University | 2020-08-01 | 2020-06-25 | |
| The Effect of Casein Phosphopeptide Amorphous Calcium Phosphate on Affected Dentine Casein phosphopeptide amorphous calcium phosphate, Atraumatic restorative treatment - Caries,Dental | Phase 2 | Unknown | Hams Hamed Abdelrahman | 132 | 2020-03-01 | 2020-03-11 |
| Efficacy of PRF and MTA as Compared to Calcium Hydroxide for Pulpotomy in Human Irreversibly Inflamed Permanent Teeth Calcium hydroxide, MTA, PRF - Pulpitis - Irreversible, Tooth Decay | Phase 2 | Completed | Liaquat College of Medicine and Dentistry | 114 | 2019-08-28 | 2022-08-17 |
| Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric Kovanaze Nasal Spray, Articaine Injection - Caries,Dental, Apical Periodontitis | Phase 2 | Terminated | Virginia Commonwealth University | 3 | 2019-08-28 | 2020-11-19 |
| Pharmacokinetics of Advantage Arrest in Children Silver Diamine Fluoride - Dental Caries | Phase 2 | Completed | Advantage Silver Dental Arrest, LLC | 59 | 2019-08-01 | 2022-03-10 |
| Impact of Minimally Invasive Restorative Techniques on Pregnant Women Oral Health Related Quality of Life Papacarie, Atraumatic Restorative Treatment - Quality of Life, Dental Caries | Phase 2 | Completed | Nourhan M.Aly | 162 | 2019-01-10 | 2023-12-04 |
| Clinical Evaluation of Bioactive Resin Sealants vs Conventional Sealants in Permanent Molars BioCoat® by Premier®., 3M™ Clinpro™ Sealant. - Caries, Dental | Phase 1 / Phase 2 | Unknown | Cairo University | 38 | 2019-01-01 | 2019-01-15 |
| Child Discomfort and Parental Acceptability of Silver Diamine Fluoride and Alternative Restorative Treatment SDF, ART - Dental Caries, Child Discomfort | Phase 2 / Phase 3 | Completed | Nourhan M.Aly | 80 | 2018-10-12 | 2020-12-04 |
Showing 20 of 69. Sign in to see all of them.
Dental Caries (64) · Periapical Periodontitis (3) · Tooth Erosion (3) · Dental Pulp Exposure (2) · Dental Plaque (1) · Dentin Sensitivity (1) · Exanthema (1) · Long Term Adverse Effects (1) · Plaque, Amyloid (1) · Root Caries (1) · Van der Woude syndrome (1)
Stomatognathic Diseases (69) · Tooth Diseases (69) · Jaw Diseases (3) · Mouth Diseases (3) · Periapical Diseases (3) · Periodontal Diseases (3) · Periodontitis (3) · Tooth Wear (3) · Dental Pulp Diseases (2) · Pathological Conditions, Signs and Symptoms (2) · Dental Caries (1) · Dental Deposits (1) · Pathologic Processes (1) · Pathological Conditions, Anatomical (1)
silver diamine fluoride (8) · Sodium Fluoride (4) · casein phosphopeptide-amorphous calcium phosphate nanocomplex (4) · Antimicrobial Peptides (3) · Calcium Hydroxide (3) · Carticaine (3) · Oxymetazoline (3) · Tetracaine (3) · Bifluorid 12 (2) · Control Groups (2) · Dental Atraumatic Restorative Treatment (2) · Pemetrexed (2) · Probiotics (2) · Water (2) · Adhesives (1)
Armata Pharmaceuticals, Inc. (7) · The University of Hong Kong (7) · Cairo University (4) · Advantage Silver Dental Arrest, LLC (3) · Colgate Palmolive (3) · Nourhan M.Aly (3) · Virginia Commonwealth University (3) · GlaxoSmithKline (2) · Indiana University (2) · University of Jazan (2) · Advantage Dental Services, LLC (1) · Aline R F de Castilho (1) · Beenish Hassan (1) · Brain-Gut Research Group (1) · Cargill (1)
United States (19) · Egypt (7) · China (4) · Brazil (3) · Hong Kong (3) · Chile (2) · India (2) · Pakistan (2) · Saudi Arabia (2) · Canada (1) · Colombia (1) · Estonia (1) · Malaysia (1) · Micronesia (1) · Puerto Rico (1)
Edward CM Lo, BDS, PhD (3) · John Pittaway, DMD (3) · Parthasarathy Madurantakam, DDS, PhD (3) · Bennet Amaechi, PhD, DDS (2) · Wafaa E Abdelaziz, PhD (2) · Adam D Marberger, DDS (1) · Adam Marberger, DDS (1) · Ahmad Shuhud Irfani Zakaria, MClinDent (1) · Ahmed H. Samaha, BSc (1) · Aline RF Castilho, PhD (1) · Amel M Ahmed, Phd (1) · Amira Farid, PHD (1) · Athena Papas, DMD, PhD (1) · Azza G. Hanno, Professor (1)
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D43TW007768 (1), U54DE019285 (1)