20 completed, 12 unknown, 1 recruiting. 16 Not applicable, 7 Phase 2, 6 Phase 4, 2 Phase 3, 1 Early Phase 1.
Follow casein phosphopeptide-amorphous calcium phosphate nanocomplex: new trials by email Literature Review of casein phosphopeptide-amorphous calcium phosphate nanocomplex trials Research Report on casein phosphopeptide-amorphous calcium phosphate nanocomplex
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics MI Paste Plus (CPP-ACP with Sodium Fluoride), Bioadhesive Oral Gel (Placebo) - Dental Caries, Streptococcus Mutans | Not applicable | Recruiting | Cardenal Herrera University | 200 | 2026-01-04 | 2026-03-27 |
| Effect Of Three Remineralizing Agents On Early Childhood Caries Silver Diamine Fluoride (SDF, 38%), Sodium Fluoride with CPP-ACP, Acidulated phospahate fluoride gel 1.23% - Early Childhood Caries (ECC), Dental Caries | Phase 2 | Completed | University of Jazan | 90 | 2025-11-01 | 2026-09-10 |
| Effect of Different Remineralizing Agents on White Spot Lesions Treatment in Children Casein phosphopeptide-amorphous calcium phosphate, Casein phosphopeptide-amorphous calcium phosphate + fluoride, Nano hydroxyapatite paste - White Spot Lesion of Tooth | Not applicable | Completed | National Research Centre, Egypt | 100 | 2024-12-01 | 2025-02-12 |
| Efficacy of Different Agents in Treatment of Initial Caries on Smooth Surfaces in Permanent Teeth in Children Self-assembling peptide (P11-4), CPP-ACFP, Resin infiltration - White Spot Lesion of Tooth | Phase 3 | Unknown | Plovdiv Medical University | 40 | 2024-06-01 | 2024-05-09 |
| Evaluation of the Effectiveness of Home-Use Desensitizing Agents on Dentin Hypersensitivity Control group, Arginine, Novamin - Dentin Sensitivity | Not applicable | Completed | Çanakkale Onsekiz Mart University | 180 | 2024-03-01 | 2024-08-26 |
| Effects of Different Remineralization Agents on Molar Incisor Hypomineralization Defects: a Randomized Clinical Study Fluoride - Molar Incisor Hypomineralization | Not applicable | Unknown | Universidad Nacional Autonoma de Mexico | 100 | 2024-03-01 | 2024-04-12 |
| Fluoride Delivery to Prevent White Spots During Orthodontic Treatment Fluoride mouthwash (0.05%; 225ppm)., Tooth Mousse Plus - Orthodontic Appliance Complication, Tooth Demineralization | Phase 4 | Unknown | Liverpool University Hospitals NHS Foundation Trust | 130 | 2023-10-20 | 2023-11-08 |
| White Spot Lesions Treatment in Orthodontic 5% sodium fluoride, Intensive 5% sodium fluoride, Casein Phosphopeptide-Amorphous Calcium Phosphate - White Spot Lesion | Phase 4 | Unknown | Riyadh Elm University | 88 | 2023-10-01 | 2023-09-25 |
| Effectiveness of Different Remineralizing Strategies on the Management of Early Carious Lesions in Primary Teeth self assmbling peptide p11-4 combined with 0.05% fluoride, Casein phosphopeptide amorphous calcium phosphate, 5% sodium fluoride varnish - White Spot Lesion | Early Phase 1 | Completed | Alexandria University | 66 | 2023-08-15 | 2025-01-29 |
| Resin Infiltration Versus Microabrasion With CPP-ACP for Fluorotic White Spot Lesions Resin infiltration, Enamel Microabrasion Plus CPP-ACP - Dental Fluorosis | Not applicable | Completed | Hue University of Medicine and Pharmacy | 42 | 2023-06-01 | 2026-07-15 |
| Impact of Chewing Gum With CPP-ACP on Tooth Mineralisation in Situ Sugar free gum without CPP-ACP, Sugar free gum with CPP-ACP - Tooth Demineralization | Not applicable | Unknown | Mondelēz International, Inc. | 14 | 2021-10-01 | 2021-10-18 |
| The Effect of Different Remineralizing Agents on White Spot Lesions and Dental Plaque During Orthodontic Retention Fluoridated toothpaste, fluoride varnish (5% sodium fluoride), CPP-ACP plus crème group - Orthodontic Appliance Complication | Not applicable | Unknown | University of Malaya | 30 | 2021-03-17 | 2021-10-22 |
| Clinical Evaluation of the Efficacy of SPR-G Barrier Coat Versus Fluoride Varnish Versus MI Paste in the Treatment of Early White Spot Lesions in Pediatric Patients PRG Barrier Coat, Fluoride varnish, MI paste - White Spot Lesions [Initial Caries] on Smooth Surface of Tooth | Phase 1 | Unknown | Ain Shams University | 60 | 2021-01-01 | 2022-01-24 |
| Bioactive Glass in the Treatment of Enamel White Spot Lesions BiominF, Novamin, CPP-ACP - White Spot Lesion of Tooth | Phase 3 | Completed | Rania Salah | 60 | 2020-06-01 | 2021-10-19 |
| The Effect of Casein Phosphopeptide Amorphous Calcium Phosphate on Affected Dentine Casein phosphopeptide amorphous calcium phosphate, Atraumatic restorative treatment - Caries,Dental | Phase 2 | Unknown | Hams Hamed Abdelrahman | 132 | 2020-03-01 | 2020-03-11 |
| Medical Treatment of Early-Enamel Carious Lesion Using Different Remeneralizing Agents Silver diamine fluoride- potassium iodide, Casein phosphopeptide amorphous calcium phosphate, experimental tricalcium silicate - Enamel Caries | Not applicable | Completed | Mansoura University | 45 | 2019-12-01 | 2022-04-05 |
| Caries Prevention Potential of Pearl Powder Versus CPP-ACP on Enamel White Spot Lesions pearl powder, CPP-ACP - White Spot Lesion of Tooth | Phase 2 | Unknown | Ruba Alaa El Din Adel El Damarisy | 58 | 2019-10-30 | 2019-06-07 |
| Remineralization Potential of Pearl Powder Compared to CPP-ACP on Enamel White Spot Lesions Cpp-Acp, Pearl powder - White Spot Lesion | Phase 2 | Unknown | Cairo University | 62 | 2019-09-01 | 2019-06-07 |
| Effect of Casein Phosphopeptide Amorphous Calcium Phosphate Fluoride Varnish on Remineralization of White Spot Lesion in Primary Teeth CPP-ACP, Duraphat - White Spot Lesion | Phase 2 | Completed | Nourhan M.Aly | 180 | 2019-04-28 | 2020-04-22 |
| Remineralization Potential of MI Varnish Versus Fluoride Varnish on White Spot Lesions in Maxillary Primary Incisors MI varnish - Remineralization Effect of the Varnish on White Spot Lesions | Not applicable | Completed | Cairo University | 60 | 2019-03-01 | 2020-07-21 |
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Dental Caries (5) · Tooth Demineralization (4) · Dentin Sensitivity (2) · Tooth Erosion (2) · Fluorosis, Dental (1) · Infections (1) · Molar Hypomineralization (1) · Mucositis (1) · Paresthesia (1) · Tooth Discoloration (1) · Xerostomia (1)
Cairo University (3) · Jordan University of Science and Technology (2) · Ain Shams University (1) · Alexandria University (1) · Azad University of Medical Sciences (1) · Cardenal Herrera University (1) · Fujian Medical University (1) · Hams Hamed Abdelrahman (1) · Hue University of Medicine and Pharmacy (1) · King Abdulaziz University (1) · Kırıkkale University (1) · Liverpool University Hospitals NHS Foundation Trust (1) · Mansoura University (1) · Merve Erkmen Almaz (1) · Mondelēz International, Inc. (1)
Egypt (9) · United States (3) · Jordan (2) · Saudi Arabia (2) · Turkey (Türkiye) (2) · Albania (1) · Bulgaria (1) · Iran (1) · Malaysia (1) · Mexico (1) · Switzerland (1) · Thailand (1) · United Kingdom (1) · Vietnam (1)
Ola Al-Batayneh, MDSc, FRACDS (2) · Ahmed I Mekky, BDS (1) · Amr Abd El Aziz, Professor (1) · Ani Belcheva, PhD (1) · Annette Wiegand, PD Dr. med. dent. (1) · Azza G. Hanno, Professor (1) · Dalia AM Talaat, PhD (1) · Greg H Huang, DMD,MSD,MPH (1) · Hao Yu, DDS, PhD (1) · Heather Rogers (1) · Heba J Sabbagh, PHD (1) · Karin M. Dowidar, Professor (1) · Karin ML Dowidar, PhD (1) · Mohamed A. Bayoumi, MSc (1)
PMID 10343087, PMID 1054935, PMID 12532056, PMID 1390575, PMID 14738126, PMID 15266503, PMID 1590288, PMID 16230329, PMID 17026510, PMID 17561043, PMID 17634723, PMID 17977295, PMID 18305389, PMID 20020086, PMID 20348890, PMID 20887516, PMID 21083623, PMID 21536209, PMID 22051486, PMID 22502564, PMID 22805294, PMID 23158136, PMID 23273358, PMID 25038509, PMID 25126675, PMID 26418918, PMID 27007355, PMID 285114, PMID 29857075, PMID 30719933, PMID 32356211, PMID 3276146, PMID 33009565, PMID 39810073, PMID 39907699, PMID 40830200, PMID 4528489, PMID 5288673, PMID 6605091, PMID 6758594, PMID 9294493
D43TW007768 (1)