37 completed, 29 unknown, 5 not yet recruiting, 2 active not recruiting. 40 Not applicable, 14 Phase 3, 13 Phase 2, 10 Phase 4, 3 Phase 1.
Follow silver diamine fluoride: new trials by email Literature Review of silver diamine fluoride trials Research Report on silver diamine fluoride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Performance of High Viscous Glass Ionomer Cervical Restorations With Silver-Modified Atraumatic Restorative Technique (SMART) Versus Conventional Treatment in Elderly Cancer Patients. (A 12-month Randomized Clinical Trial) Silver Diamine Fluoride (SDF, 38%), Conventional Tooth Preparation, High-Viscosity Glass Ionomer Cement - Dental Caries, Cervical Caries | Not applicable | Not yet recruiting | Cairo University | 30 | 2027-01-15 | 2026-10-19 |
| Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected Molars Standard Local Anesthesia, Intraoral Cryotherapy, Silver Diamine Fluoride (SDF) - MIH, Molar-Incisor Hypomineralization | Not applicable | Not yet recruiting | Çanakkale Onsekiz Mart University | 75 | 2026-02-01 | 2026-01-08 |
| Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children Nano-Silver Fluoride, Silver Diamine Fluoride - Early Childhood Caries (ECC), Active Dentin Caries in Primary Molars | Not applicable | Not yet recruiting | October University for Modern Sciences and Arts | 60 | 2026-01-30 | 2026-02-02 |
| Effectiveness and Acceptability of SDF Compared to ART for the Management of Early Childhood Caries Silver Diamine Fluoride, Atraumatic Restorative Treatment - Early Childhood Caries, Health Care Acceptability | Not applicable | Not yet recruiting | Universidad de La Frontera | 156 | 2025-12-15 | 2025-12-12 |
| Effect Of Three Remineralizing Agents On Early Childhood Caries Silver Diamine Fluoride (SDF, 38%), Sodium Fluoride with CPP-ACP, Acidulated phospahate fluoride gel 1.23% - Early Childhood Caries (ECC), Dental Caries | Phase 2 | Completed | University of Jazan | 90 | 2025-11-01 | 2026-09-10 |
| Effects of Different Remineralization Agents on the Progression of Non-Cavitated Approximal Carious Lesions in Primary Teeth: A Randomized Clinical Trial P11-4 + NaF Varnish, Silver diamine fluoride, NaF Varnish Alone - Dental Caries | Not applicable | Active not recruiting | Izmir Katip Celebi University | 90 | 2025-10-01 | 2026-02-24 |
| SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children Sodium Fluoride Varnish (5%), Silver Diamine Fluoride (38%) - Dental Caries | Not applicable | Recruiting | Assiut University | 48 | 2025-09-15 | 2025-11-18 |
| CARIES ARREST USING SILVER DIAMINE FLUORIDE VERSUS FISSURE SEALANT IN OCCLUSAL DENTAL CARIOUS LESIONS Silver Diamine Fluoride (SDF), VOCO Fissurit - Dental Caries, Caries Arrested | Not applicable | Completed | Cairo University | 76 | 2025-04-01 | 2026-07-20 |
| Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries Silver diamine fluoride- potassium iodide, Fluoride varnish, 0.9 % saline - Demineralization, Tooth, White Spot Lesion of Tooth | Phase 2 | Not yet recruiting | National University of Malaysia | 99 | 2025-01-31 | 2025-01-30 |
| Silver Diamine Flouride in Arresting Enamel Caries 38% Silver Diamine Fluoride - Carious Lesion | Not applicable | Completed | HITEC-Institute of Medical Sciences | 250 | 2024-05-07 | 2025-08-15 |
| Comparison of Cariostatic Effect of Nano-Silver Fluoride Versus Silver Diamine Fluoride Nano-Silver Fluoride, Silver diamine fluoride - Dental Caries in Children | Phase 1 | Active not recruiting | Cairo University | 78 | 2024-02-07 | 2024-10-16 |
| Comparing the Effectiveness of Papain Based Chemico-mechanical Caries Removal Gel and 38% Silver Diamine Fluoride for Treating Active Caries Lesion of Primary Molars Cera-bur, Brix3000, E-SDF - Dental Caries in Children | Not applicable | Completed | Al-Mustansiriyah University | 45 | 2024-01-02 | 2025-05-08 |
| Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient Silver diamine Fluoride 38%, Silver diamine fluoride- potassium iodide - Dental Caries | Phase 4 | Recruiting | King Abdulaziz University | 50 | 2023-11-01 | 2025-03-06 |
| Effectiveness and Retention of Pit and Fissure Sealants in Rural Setup: A School-based Clinical Trial in Nepal Glass Ionomer cement pit and fissure sealant, Silver Diamine Fluoride - Dental Caries Pit and Fissure, Oral Disease | Unknown | Kathmandu University School of Medical Sciences | 377 | 2023-08-10 | 2023-06-08 | |
| SDF for the Management of Dental Caries in Children in Primary Dental Care: Protocol for a Feasibility Study Silver diamine fluoride, Usual dental care - Dental Caries in Children | Not applicable | Unknown | Sheffield Teaching Hospitals NHS Foundation Trust | 80 | 2023-06-22 | 2023-10-23 |
| SDF Effectiveness on Arresting Caries in Children Silver Diamine Fluoride (SDF), Glass Ionomer Restoration (GI), Sodium fluoride varnish with nano-sliver particles (NaF-AgNP) - Dental Caries in Children | Phase 4 | Unknown | Umm Al-Qura University | 60 | 2023-06-01 | 2024-04-04 |
| Pharmacokinetics of Advantage Arrest in Healthy Children 13-Months to 13-Years of Age 38% silver diamine fluoride - Dental Caries in Children | Phase 2 | Completed | Advantage Silver Dental Arrest, LLC | 23 | 2023-03-01 | 2024-08-06 |
| The Anticariogenic Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish Silver diamine fluoride, Sodium fluoride - Early Childhood Caries | Phase 1 | Completed | Universiti Teknologi Mara | 49 | 2023-02-01 | 2024-03-18 |
| Efficacy of the Use of Silver Diamine Fluoride and Sodium Fluoride Varnish for the Treatment of Caries in Children Silver diamine fluoride 38% followed by Sodium fluoride varnish 5% - Dental Caries in Children | Completed | Universidad Mayor de San Simón | 199 | 2022-11-07 | 2023-11-18 | |
| Clinical Effectiveness and Parental Acceptance of Silver Diamine Fluoride in Preschool Children: A Non-randomized Trial Silver Diamine Fluoride - Silver Diamine Fluoride | Not applicable | Completed | Cumhuriyet University | 48 | 2022-08-10 | 2024-03-05 |
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Dental Caries (32) · Root Caries (4) · Molar Hypomineralization (2) · Child Behavior (1) · Communicable Diseases (1) · Dental Enamel Hypomineralization (1) · Dental Plaque (1) · Dentin, Secondary (1) · Exanthema (1) · Gingivitis (1) · Heart Arrest (1) · Mouth Diseases (1) · Patient Acceptance of Health Care (1) · Patient Compliance (1) · Personal Satisfaction (1)
Cairo University (16) · The University of Hong Kong (7) · Advantage Silver Dental Arrest, LLC (3) · University of Sao Paulo (3) · NYU College of Dentistry (2) · Nourhan M.Aly (2) · University of Malaya (2) · University of Michigan (2) · Advantage Dental Services, LLC (1) · Al-Azhar University (1) · Al-Mustansiriyah University (1) · Alexandria University (1) · Assiut University (1) · Beaty Dent (1) · British University In Egypt (1)
Egypt (20) · United States (11) · Brazil (5) · China (5) · Malaysia (4) · Saudi Arabia (4) · Turkey (Türkiye) (3) · Iraq (2) · Pakistan (2) · Albania (1) · Bolivia (1) · Canada (1) · Chile (1) · Hong Kong (1) · India (1)
Nevine G Waly, Professor (3) · Chun Hung Chu (2) · Edward CM Lo, BDS, PhD (2) · Eman S Elmasry, Professor (2) · Fatma KI Abdelgawad, Lecturer (2) · Mariana M Braga, PhD (2) · Peter Milgrom, DDS (2) · Richard Niederman, DMD (2) · Abla Arafa (1) · Ahmad Shuhud Irfani Zakaria, MClinDent (1) · Ana Lucia Vollu, MSD Student (1) · Anas Imran Arshad, MSc., BDS (1) · Basma Gamal, Lecturer (1)
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R01MD011526 (1), U01DE027372 (1)