9 completed, 6 unknown, 1 active not recruiting. 5 Not applicable, 5 Phase 2, 4 Phase 4, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 3, Unknown 2 |
| Phase 2 | 5 | Completed 3, Active not recruiting 1, Unknown 1 |
| Phase 4 | 4 | Unknown 3, Completed 1 |
| Phase 3 | 3 | Completed 2, Unknown 1 |
Follow Bifluorid 12: new trials by email Literature Review of Bifluorid 12 trials Research Report on Bifluorid 12
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Preventing Early Childhood Caries With a Silver Diamine Fluoride Gel Silver diamine fluoride gel, Sodium Fluoride varnish - Early Childhood Caries (ECC) | Phase 2 | Active not recruiting | The University of Hong Kong | 1500 | 2026-01-01 | 2026-03-06 |
| Evaluation of Biomimetic Mineralization Plus Soft Laser Irradiation in Dentin Hypersensitivity Management Sodium fluoride varnish, Curodont De Senz, Curodont De Senz plus laser irradiation - Dentin Hypersensitivity | Not applicable | Completed | MTI University | 84 | 2024-11-01 | 2025-07-29 |
| Comparative Effectiveness of Remineralization Agents on Attachment-Associated Demineralization in Clear Aligner Patients GC Tooth Mousse, Nano-Hydroxyapatite Gel, Sodium Fluoride varnish - White Spot Lesions, Demineralization | Not applicable | Completed | Bezmialem Vakif University | 40 | 2024-08-12 | 2025-11-14 |
| Remineralization of Dentine Caries Using Two Remineralizing Agents Which Are Nanosilver Fluoride and Casein phosphopeptides_amorphous Calcium Phosphate Nanosilver fluoride, Sodium fluoride with casein phosphopeptides amorphous calcium phosphate, Sodium fluoride varnish - Dental Caries | Not applicable | Unknown | University of Baghdad | 135 | 2021-08-10 | 2022-05-17 |
| Cariostatic and Remineralizing Effects of Three Different Dental Varnishes Nano Silver Fluoride varnish, nano-hydroxyapatite varnish, sodium Fluoride Varnish - Dental Caries in Children, Cariostatic Agent | Phase 4 | Completed | Nisreen Ibrahim khan | 115 | 2021-08-01 | 2024-04-02 |
| Arrest of Interproximal Caries Lesion With 38% Silver Diamine Fluoride Solution Silver diamine fluoride, Sodium fluoride varnish - Caries Arrested | Phase 3 | Completed | Postgraduate Institute of Dental Sciences Rohtak | 45 | 2021-08-01 | 2023-03-30 |
| P11-4 and Nanosilver Fluoride Varnish in Treatment of White Spot Carious Lesions self-assembling peptide, nanosilver fluoride varnish, sodium fluoride varnish - White Spot Lesion | Not applicable | Unknown | Hams Hamed Abdelrahman | 66 | 2020-12-05 | 2021-06-18 |
| Silver Diamine Fluoride in Preventing Occlusal Caries in Primary Teeth silver diamine fluoride, sodium fluoride varnish, tonic water - Dental Caries in Children | Phase 2 / Phase 3 | Unknown | The University of Hong Kong | 769 | 2020-03-01 | 2021-10-19 |
| Effect of Casein Phosphopeptide Amorphous Calcium Phosphate Fluoride Varnish on Remineralization of White Spot Lesion in Primary Teeth CPP-ACP, Duraphat - White Spot Lesion | Phase 2 | Completed | Nourhan M.Aly | 180 | 2019-04-28 | 2020-04-22 |
| the Efficacy of Giomer Versus Sodium Fluoride in the Treatment of Hypersensitivity shofu PRG barrier coat, Sodium fluoride varnish - Tooth Hypersensitivity | Phase 4 | Unknown | Cairo University | 104 | 2019-03-01 | 2019-01-28 |
| Discoloration of Carious Primary Teeth After Application of Silver Diamine Fluoride Versus Sodium Fluoride Varnish Silver Diamine Fluoride, Sodium Fluoride Varnish - Dental Caries in Children | Phase 4 | Unknown | Cairo University | 42 | 2018-12-01 | 2018-06-18 |
| Application of SDF Verses NaF Varnish in Treatment of Carious Primary Teeth Silver Diamine Fluoride, Sodium Fluoride varnish - Dental Caries in Children | Phase 4 | Unknown | Cairo University | 46 | 2018-12-01 | 2018-06-14 |
| Efficacy of Seventh Generation Bonding Agents as Short-Term Desensitizers Among Patients With Hypersensitivity Single Bond Universal, Bifluorid 12, Xeno V+ - Dentin Hypersensitivity | Phase 3 | Completed | Dow University of Health Sciences | 105 | 2018-03-07 | 2020-01-18 |
| Efficacy Of A PVP-I Fluoride Varnish Test varnish, Standard varnish - Dental Caries | Phase 2 | Completed | Advantage Dental Services, LLC | 284 | 2017-03-30 | 2020-09-10 |
| Cost Effectiveness of Sodium Fluoride Varnish in Prevention of Dental Caries in School Children 5% sodium fluoride varnish, WATER ON TEETH - Dental Caries in Children | Not applicable | Completed | University of Peradeniya | 328 | 2015-01-02 | 2018-06-29 |
| Cost-effectiveness of Four Methods in Preventing Fissure Caries in Permanent Teeth ART dental sealant, Resin dental sealant, Sodium fluoride varnish - Dental Caries | Phase 2 | Completed | The University of Hong Kong | 329 | 2006-06-01 | 2013-04-11 |
Dental Caries (6) · Dentin Sensitivity (3) · Gingival Recession (1)
Cairo University (3) · The University of Hong Kong (3) · Advantage Dental Services, LLC (1) · Bezmialem Vakif University (1) · Dow University of Health Sciences (1) · Hams Hamed Abdelrahman (1) · MTI University (1) · Nisreen Ibrahim khan (1) · Nourhan M.Aly (1) · Postgraduate Institute of Dental Sciences Rohtak (1) · University of Baghdad (1) · University of Peradeniya (1)
Egypt (7) · China (3) · India (1) · Iraq (1) · Micronesia (1) · Pakistan (1) · Turkey (Türkiye) (1)
Eman S Elmasry, Professor (2) · Fatma KI Abdelgawad, Lecturer (2) · Nevine G Waly, Professor (2) · Ahmed I Mekky, BDS (1) · Ahmed M Sayed, Assis. prof. (1) · Chun Hung Chu (1) · Dalia AM Talaat, PhD (1) · Duaa Jawad (1) · Edward CM Lo (1) · Hala A Amer, PHD (1) · Karin ML Dowidar, PhD (1) · Marwa A Salmoon, MSc (1) · Peter M Milgrom, DDS (1) · Salwa A Hegazy, PhD (1)
PMID 18491761, PMID 19498220, PMID 20129891, PMID 24818873, PMID 24886444, PMID 25506416, PMID 28667230, PMID 30854195, PMID 32437626, PMID 35604758, PMID 37598194, PMID 38388987, PMID 38745306, PMID 40817745, PMID 41382095