8 completed, 6 recruiting, 2 suspended, 2 unknown. 9 Phase 2, 7 Phase 1, 4 Not applicable, 3 Early Phase 1, 1 Phase 3.
Follow THC: new trials by email Literature Review of THC trials Research Report on THC
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| THC Titration of High-Potency Cannabis Concentrates Cannabis (30% THC Concentrate), Cannabis (60% THC Concentrate), Cannabis (90% THC Concentrate) - THC | Not applicable | Recruiting | Centre for Addiction and Mental Health | 48 | 2025-10-01 | 2026-06-11 |
| Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks THC, Placebo - THC | Phase 2 | Not yet recruiting | Yale University | 50 | 2025-08-31 | 2025-06-10 |
| Pilot fMRI Studies of Aging-Related Effects of THC THC, Placebo - THC | Phase 2 | Recruiting | Yale University | 10 | 2025-07-01 | 2025-10-09 |
| Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration Cannabis, Nicotine, Pax Loose Leaf Vaporizer - THC, Cannabis | Phase 2 | Recruiting | University of California, San Francisco | 48 | 2025-07-01 | 2026-01-07 |
| Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults 15% THC Potency Reduction, 35% THC Potency Reduction - Cannabis Use, THC | Not applicable | Suspended | University of California, San Francisco | 110 | 2025-03-17 | 2026-04-13 |
| Behavioral Pharmacology of Orally Administered THC and D-limonene D-Limonene, Delta-9-THC, Placebo - Subjective Drug Effects, THC | Phase 1 | Recruiting | Johns Hopkins University | 65 | 2025-02-14 | 2026-05-28 |
| Modulation of THC Effects by CBD: a Dose-ranging Study ∆9-tetrahydrocannabinol - Cannabis, THC | Phase 1 / Phase 2 | Recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 100 | 2024-06-27 | 2025-12-22 |
| Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV THC, CBD - HIV, Cannabis | Phase 2 | Recruiting | University of California, San Diego | 90 | 2023-09-01 | 2026-05-01 |
| Dose-Ranging Trial of Inhaled Cannabis for Acute Migraine Treatment THC ~2.5%, THC ~5%, THC ~10% - Migraine, Cannabis | Phase 2 | Suspended | University of California, San Diego | 20 | 2023-02-15 | 2026-03-16 |
| Characterization of the Pharmacodynamic Response to Vaped THC THC or Placebo - Vaping, THC | Phase 3 | Withdrawn | Massachusetts General Hospital | 2022-11-01 | 2022-02-11 | |
| THC Memory & Reward Learning Pilot Marijuana, Hash, THC, or Grass, Placebo - Marijuana, THC | Phase 1 / Phase 2 | Unknown | Hartford Hospital | 20 | 2022-07-07 | 2025-03-17 |
| A Study to Investigate the Bioavailability and Skin Absorption of CBD and THC From GT4 Technology in Healthy Adults CBD and THC with GT4 technology - Biological Availability, Skin Absorption | Phase 1 | Completed | Gefion Canada Inc. | 18 | 2021-11-27 | 2022-06-01 |
| A Study of Cybis™ 10:25 THC:CBD Oil in Adults With Chronic Back/Neck Pain Cybis™ 10:25 THC:CBD oil - Chronic Pain, Neck Pain | Phase 1 / Phase 2 | Completed | Cymra Life Sciences | 28 | 2021-09-20 | 2022-07-07 |
| Efficacy of Inhaled Cannabis for Acute Migraine Treatment THC ~5%, CBD ~12%, THC ~5% and CBD ~12% - Migraine, Cannabis | Phase 2 | Completed | University of California, San Diego | 92 | 2020-11-20 | 2023-02-28 |
| Behavioral Pharmacology of THC and Alpha-pinene Placebo, THC, Alpha-Pinene - THC, Alpha-pinene | Phase 1 | Completed | Johns Hopkins University | 33 | 2020-11-05 | 2025-05-22 |
| THC Crossover Study Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette - THC, Cannabis | Not applicable | Completed | University of California, San Francisco | 14 | 2020-10-30 | 2024-07-01 |
| Age-Related Effects of THC Dextrose, Dronabinol - Tolerance, Adolescent Behavior | Early Phase 1 | Completed | University of Chicago | 24 | 2020-03-10 | 2023-11-09 |
| Do Adolescents and Adults Differ in Their Acute Response to Cannabis? Cannabis with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), Cannabis with THC without CBD, Placebo cannabis - Cannabis, Cannabis Intoxication | Not applicable | Completed | University College, London | 48 | 2019-03-11 | 2021-09-29 |
| Tetrahydrocannabinol (THC) and Sleep Dronabinol - Sleep, THC | Early Phase 1 | Completed | Oregon Health and Science University | 18 | 2018-09-01 | 2026-02-05 |
| A Bioavailability Study on Dronabinol Chewing Gum - THC | Phase 1 | Unknown | Axim Biotechnologies | 50 | 2018-01-01 | 2017-04-04 |
Showing 20 of 21. Sign in to see all of them.
Marijuana Abuse (13) · Vaping (4) · Marijuana Smoking (2) · Migraine Disorders (2) · Tobacco Use (2) · Adolescent Behavior (1) · Back Pain (1) · Chronic Pain (1) · Cigarette Smoking (1) · Cognitive Dysfunction (1) · Marijuana Use (1) · Memory Disorders (1) · Neck Pain (1) · Neuroinflammatory Diseases (1) · Pain (1)
Chemically-Induced Disorders (13) · Mental Disorders (13) · Substance-Related Disorders (13) · Behavior (5) · Nervous System Diseases (4) · Pathological Conditions, Signs and Symptoms (3) · Smoking (3) · Brain Diseases (2) · Central Nervous System Diseases (2) · Headache Disorders (2) · Headache Disorders, Primary (2) · Marijuana Use (2) · Neurologic Manifestations (2) · Signs and Symptoms (2) · Smoking, Non-Tobacco Products (2)
Dronabinol (14) · nabiximols (7) · Cannabidiol (4) · THC 5 (2) · salicylhydroxamic acid (2) · Chewing Gum (1) · Glucose (1) · Limonene (1) · Nicotine (1) · alpha-pinene (1)
University of California, San Diego (3) · University of California, San Francisco (3) · Yale University (3) · Johns Hopkins University (2) · Axim Biotechnologies (1) · Centre for Addiction and Mental Health (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Cymra Life Sciences (1) · Gefion Canada Inc. (1) · Hartford Hospital (1) · Massachusetts General Hospital (1) · Oregon Health and Science University (1) · University College, London (1) · University of Chicago (1)
United States (14) · Canada (3) · Australia (1) · United Kingdom (1)
Godfrey Pearlson, M.D (2) · Nathaniel M Schuster, MD (2) · Austin Zamarripa, PhD (1) · David Crowley, MD (1) · Didier Jutras-Aswad, MD, MS (1) · Eden Evins, MD, MPH (1) · Gideon St Helen (1) · Gideon St. Helen, PhD (1) · Jose Cortes-Briones, PhD (1) · Michael Sofis, PhD (1) · Mohini Ranganathan, MD (1) · Richard Chye (1) · Ronald J Ellis, MD, PhD (1) · Ryan Vandrey, PhD (1) · Steven A Shea, PhD (1)
PMID 35032682, PMID 36308640, PMID 36642667, PMID 36750134, PMID 38416223, PMID 41469488
R01DA043475 (1), R01DA056451 (1), R03DA054453 (1), R21DA061350 (1)