38 completed, 11 recruiting, 8 terminated, 4 active not recruiting. 67 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 67 | Completed 38, Recruiting 11, Terminated 8, Active not recruiting 4, Not yet recruiting 2, Unknown 2, Enrolling by invitation 1, Withdrawn 1 |
Follow Tauopathies: new trials by email Literature Review of Tauopathies trials Research Report on Tauopathies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device. Structured wellness care, Wearable brain-computer interface devices, Stem Cell Therapy - Experimental - Mild Cognitive Impairment (MCI), Early Stages of Cognitive Decline | Early Phase 1 | Not yet recruiting | Noah Tech, Corp. | 600 | 2026-09-01 | 2026-03-10 |
| First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate - Progressive Supranuclear Palsy (PSP), Healthy Participants | Early Phase 1 | Completed | Invicro | 11 | 2025-11-17 | 2026-07-10 |
| An Exploratory Study of Near-infrared Light Therapy for Mild to Moderate Alzheimer's Disease Near infrared light therapy - Alzheimer Disease | Early Phase 1 | Not yet recruiting | Xuanwu Hospital, Beijing | 40 | 2025-10-30 | 2025-09-15 |
| Investigator Initiated Trial of Galcanezumab Treatment in Alzheimer's Disease Galcanezumab - Alzheimer Disease | Early Phase 1 | Recruiting | Xuanwu Hospital, Beijing | 10 | 2025-08-01 | 2026-01-07 |
| Intravenous Infusion of Umbilical Cord Blood as an Adjunctive Treatment for Alzheimer's Disease Intravenous infusion of mononuclear cells from umbilical cord blood, Conventional medical treatment：donepezil, rivastigmine or galantamine - Alzheimer Disease (AD) | Early Phase 1 | Recruiting | Anhui Provincial Hospital | 30 | 2025-07-31 | 2025-10-06 |
| Near-Infrared Light Therapy Combined With Lecanemab for Mild Alzheimer's Disease NirsCure with Lecanemab, sham NirsCure with Lecanemab - Alzheimer Disease | Early Phase 1 | Recruiting | Xuanwu Hospital, Beijing | 20 | 2025-05-28 | 2025-09-09 |
| Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183A 18F-JSS20-183A PET, Brain MRI, Amyloid PET - Tauopathies | Early Phase 1 | Recruiting | University of Pennsylvania | 90 | 2025-05-09 | 2025-12-23 |
| [18F]ACI-19626 PET in TDP-43 Proteinopathies [18F]ACI-19626 - Frontotemporal Dementia (FTD), Amyotrophic Lateral Sclerosis (ALS) | Early Phase 1 | Recruiting | AC Immune SA | 45 | 2025-01-21 | 2026-08-26 |
| Recombinant Human Serum Albumin in the Treatment of Mild-to-moderate AD (Alzheimer's Disease) Exploratory Clinical Trial Recombinant Human Serum Albumin - Alzheimer's Disease (AD) | Early Phase 1 | Completed | Shenzhen Protgen Co., Ltd. | 30 | 2024-08-27 | 2026-08-25 |
| Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia Psychosocial educational, support group and implementation of strategies - Alzheimer Disease, Dementia | Early Phase 1 | Recruiting | University of Texas at Austin | 120 | 2024-05-21 | 2026-06-10 |
| Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503 11C-M503 PET, Brain MRI, Amyloid PET - Tauopathies | Early Phase 1 | Recruiting | University of Pennsylvania | 70 | 2024-02-16 | 2026-04-24 |
| Plasma Dilution and Infusion to Improve Cognition in Mild Cognitive Impairment (MCI) Plasma exchenge - Alzheimer Disease | Early Phase 1 | Unknown | Oslo University Hospital | 10 | 2023-12-07 | 2024-01-31 |
| Safety and Pharmacokinetics of Single Ascending Doses and Multiple Ascending Doses of CS6253 in Healthy Volunteers CS6253 Solution for Injection, Placebo - Alzheimer's Disease | Early Phase 1 | Completed | Artery Therapeutics, Inc. | 66 | 2023-10-23 | 2025-05-11 |
| Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15 11C-HY-2-15 PET, brain MRI, Amyloid PET scan - Tauopathies | Early Phase 1 | Recruiting | University of Pennsylvania | 70 | 2023-07-20 | 2025-11-19 |
| Does BCG Vaccination Reduce Biomarkers of Alzheimer's Disease? BCG vaccine - Alzheimer Disease, Late Onset | Early Phase 1 | Enrolling by invitation | Tamir Ben-Hur | 60 | 2023-07-01 | 2025-03-18 |
| Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease Active rTMS, Sham rTMS - Alzheimer Disease, Mild Cognitive Impairment | Early Phase 1 | Recruiting | Massachusetts General Hospital | 30 | 2023-05-01 | 2026-05-06 |
| Probiotics in Mild Alzheimer's Disease Probiotic Blend Capsule - Neurodegenerative Diseases, Cognition Disorders in Old Age | Early Phase 1 | Recruiting | University of Nicosia | 40 | 2022-12-19 | 2024-12-05 |
| Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease Glycine, N-acetylcysteine, Alanine - Alzheimer Disease | Early Phase 1 | Active not recruiting | Baylor College of Medicine | 52 | 2022-02-15 | 2026-09-09 |
| Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease Time in Bed Restriction, Sleep Schedule - Alzheimer Disease, Late Onset, Mild Cognitive Impairment | Early Phase 1 | Completed | University of Pittsburgh | 99 | 2022-01-03 | 2026-07-06 |
| Selinexor for Treatment of Light Chain Amyloidosis With Relapsed/Refractory Disease Selinexor, Dexamethasone - Amyloid, Amyloidosis | Early Phase 1 | Withdrawn | Weill Medical College of Cornell University | 2021-12-01 | 2022-11-17 |
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Alzheimer Disease (63) · Cognitive Dysfunction (13) · Supranuclear Palsy, Progressive (8) · Dementia (4) · Frontotemporal Dementia (4) · Parkinson Disease (4) · Amyotrophic Lateral Sclerosis (2) · Neurodegenerative Diseases (2) · Amyloidosis (1) · Anxiety Disorders (1) · Aphasia (1) · Aphasia, Primary Progressive (1) · Cognition Disorders (1) · Corticobasal Degeneration (1)
Nervous System Diseases (67) · Brain Diseases (66) · Central Nervous System Diseases (66) · Neurodegenerative Diseases (65) · Mental Disorders (64) · Neurocognitive Disorders (64) · Dementia (60) · Cognition Disorders (13) · Basal Ganglia Diseases (11) · Movement Disorders (11) · Pathological Conditions, Signs and Symptoms (11) · Neurologic Manifestations (10) · Signs and Symptoms (10) · Cranial Nerve Diseases (8)
florbetapir (5) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (2) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (2) · Idazoxan (2) · tau Proteins (2) · ((18)F)PI-2620 (1) · (methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine (1) · 1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one (1) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · Acetylcysteine (1) · Alanine (1) · Amino Acids (1) · BCG Vaccine (1) · Blood Specimen Collection (1) · Brain-Computer Interfaces (1)
Avid Radiopharmaceuticals (4) · University of Pennsylvania (4) · Institute for Neurodegenerative Disorders (3) · Janssen Research & Development, LLC (3) · Molecular NeuroImaging (3) · Xuanwu Hospital, Beijing (3) · Gregory Jicha, 323-5550 (2) · Imperial College London (2) · Invicro (2) · AC Immune SA (1) · Alkermes, Inc. (1) · AlzeCure Pharma (1) · Anhui Provincial Hospital (1) · Artery Therapeutics, Inc. (1) · Asan Medical Center (1)
United States (42) · China (6) · Netherlands (3) · Spain (3) · Belgium (2) · Canada (2) · France (2) · South Korea (2) · Sweden (2) · United Kingdom (2) · Australia (1) · Cyprus (1) · Germany (1) · Israel (1) · Norway (1)
Danna Jennings, MD (4) · David J Nutt, MD (2) · Adam Mecca, M.D., Ph.D. (1) · Akiva Mintz, MD (1) · Albert Garcia-Romeu, PhD (1) · Alberto M. Borobia Perez, MD, Ass.Prof (1) · Cara Rosenbaum, MD (1) · Chin-Chang Huang (1) · Coordinating PI (1) · Daniela Moga, MD, PhD (1) · David Russell, M.D., Ph. D (1) · Elsmarieke van de Giessen, MD (1)
PMID 20501908, PMID 23763450, PMID 26158265, PMID 26203461, PMID 27206648, PMID 29286983, PMID 29882765, PMID 31112605, PMID 31888732, PMID 32854196, PMID 34254356, PMID 34272774, PMID 34344873, PMID 35253919, PMID 36281668, PMID 36894900, PMID 38353689, PMID 38563872, PMID 39882299, PMID 40394335, PMID 41224653, PMID 41679918, PMID 41715219, PMID 42467182, PMID 42489967
2018 (1), K23AG057794 (1), R01AG033581 (1), R01AG054130 (1), R01AG059424 (1), R01AG068001 (1), R44AG076299 (1), U01DK048404 (1), UL1TR002645 (1)