16 completed, 2 recruiting, 1 not yet recruiting, 1 unknown. 20 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 20 | Completed 16, Recruiting 2, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 5 | Completed 4, Recruiting 1 |
Follow Stress: new trials by email Literature Review of Stress trials Research Report on Stress
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alaska Alliance for Community Engagement Phase II: Partnership for Action Toward Health Tools for Arctic Health Promotion - Chronic Disease, Mental Health | Phase 1 | Not yet recruiting | University of Alaska Fairbanks | 360 | 2026-09-21 | 2026-09-03 |
| Study of Cannabidiol and Neuroimaging on Stress Cannabidiol, Placebo - Early Life Adversity, Trauma | Phase 1 / Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 160 | 2025-10-29 | 2026-09-10 |
| Effects of Cannabidiol on Stress and Nicotine Withdrawal Epidiolex - CBD, Stress | Phase 1 | Recruiting | Johns Hopkins University | 90 | 2025-08-25 | 2026-08-10 |
| Impact of OnabotulinumtoxinA (BOTOX®) on Stress Intramuscular injection, OnabotulinumtoxinA (Botox®) Injections, Sodium Chloride - Stress (Psychology), Stress | Phase 1 | Completed | Center for Advanced Facial Plastic Surgery | 4 | 2025-03-19 | 2026-04-29 |
| Remote Mindfulness Training Following Early Life Adversity Mindfulness, Coping - Stress, Mindfulness | Phase 1 | Completed | University of Pittsburgh | 81 | 2022-09-01 | 2025-08-08 |
| Caring Relationships Expression Study Heart Rate Variability Biofeedback, Music Listening Control - Caregiver Burden, Anxiety | Phase 1 / Phase 2 | Completed | Arizona State University | 38 | 2021-12-13 | 2024-02-12 |
| A Study to Investigate the Efficacy of AlphaWave® L-Theanine on Stress AlphaWave® LTheanine, Placebo - Stress | Phase 1 | Completed | Ethical Naturals, Inc. | 16 | 2020-02-02 | 2021-01-12 |
| Transcranial Direct Current Stimulation (tDCS) Augments the Effects of Gamified, Mobile Attention Bias Modification ABMT, Transcranial direct current stimulation - Anxiety, Stress | Phase 1 | Completed | Hunter College of City University of New York | 38 | 2019-02-01 | 2020-04-17 |
| Differences by Sex and Genotype in the Effects of Stress on Executive Functions Methylphenidate, Vitamin C - Stress | Phase 1 | Unknown | University of British Columbia | 146 | 2018-04-28 | 2024-05-08 |
| Autologous Cell Therapy for Stress Urinary Incontinence in Males Following Prostate Surgery autologous muscle-derived cells (AMDC) - Urinary Incontinence, Stress | Phase 1 / Phase 2 | Completed | Cook MyoSite | 25 | 2015-02-19 | 2021-11-01 |
| Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures Metyrapone, Dexamethasone, Cortrosyn - Stress | Phase 1 | Completed | University of Michigan | 256 | 2012-10-01 | 2018-04-23 |
| Decreasing Stress and Improving Self-control With "Stress in Control" (Sync) Training Nutritional Counseling, Mindfulness Intervention - Stress, Obesity | Phase 1 | Completed | Yale University | 112 | 2010-09-01 | 2015-07-30 |
| Examining the Effects of CXB722 in Neuroendocrine Stress Response in Healthy Males CXB722, Placebo - Stress, Anxiety | Phase 1 | Completed | CeNeRx BioPharma Inc. | 23 | 2008-12-01 | 2009-01-13 |
| Effects of Atomoxetine Treatment in Humans Placebo, Atomoxetine - Stress | Phase 1 / Phase 2 | Completed | Yale University | 10 | 2006-06-01 | 2012-07-25 |
| Effects of Reiki on Stress Rest, Sham, Reiki - Stress | Phase 1 | Completed | The Cleveland Clinic | 257 | 2006-01-01 | 2012-09-24 |
| Effects of Massage on the Immune System of Preterm Infants massage therapy, Sham - Premature Birth, Stress | Phase 1 / Phase 2 | Completed | National Center for Complementary and Integrative Health (NCCIH) | 120 | 2005-10-01 | 2009-12-07 |
| The Effects of Smell on Mood and Physical Responses Exposure to relaxant and stimulant odors - Stress, Anxiety | Phase 1 | Completed | National Center for Complementary and Integrative Health (NCCIH) | 56 | 2005-08-01 | 2010-02-18 |
| Mindfulness Based Stress Reduction for Hot Flashes Mindfulness-based stress reduction - Hot Flashes, Stress | Phase 1 | Completed | University of Massachusetts, Worcester | 110 | 2005-01-01 | 2012-10-04 |
| New Options for Preoperative Anesthesia in Intrauterine Needling Remifentanil, saline - Stress, Pain | Phase 1 | Completed | Leiden University Medical Center | 50 | 2004-09-01 | 2009-12-08 |
| Polarity Therapy for American Indian Caregivers of Dementia Patients Polarity therapy - Stress, Depression | Phase 1 | Completed | National Center for Complementary and Integrative Health (NCCIH) | 50 | 2004-08-01 | 2008-04-22 |
Anxiety Disorders (6) · Depression (2) · Alzheimer Disease (1) · Anosmia (1) · Caregiver Burden (1) · Chronic Disease (1) · Dementia (1) · Facial Expression (1) · Fractures, Stress (1) · Hot Flashes (1) · Hyperphagia (1) · Lower Urinary Tract Symptoms (1) · Obesity (1) · Pain (1) · Premature Birth (1)
Mental Disorders (7) · Behavior (6) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (5) · Behavioral Symptoms (4) · Female Urogenital Diseases and Pregnancy Complications (2) · Nervous System Diseases (2) · Neurologic Manifestations (2) · Urogenital Diseases (2) · Body Weight (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Chemically-Induced Disorders (1) · Communication (1) · Disease Attributes (1)
Cannabidiol (2) · Sodium Chloride (2) · salicylhydroxamic acid (2) · Ascorbic Acid (1) · Atomoxetine Hydrochloride (1) · Botulinum Toxins, Type A (1) · Calcium Dobesilate (1) · Coping Skills (1) · Corticotropin-Releasing Hormone (1) · Cosyntropin (1) · Dexamethasone (1) · Injections (1) · Injections, Intramuscular (1) · Massage (1) · Methylphenidate (1)
National Center for Complementary and Integrative Health (NCCIH) (3) · Yale University (2) · Arizona State University (1) · CeNeRx BioPharma Inc. (1) · Center for Advanced Facial Plastic Surgery (1) · Cook MyoSite (1) · Ethical Naturals, Inc. (1) · Hunter College of City University of New York (1) · Icahn School of Medicine at Mount Sinai (1) · Johns Hopkins University (1) · Leiden University Medical Center (1) · The Cleveland Clinic (1) · University of Alaska Fairbanks (1) · University of British Columbia (1) · University of Massachusetts, Worcester (1)
United States (16) · Canada (2) · Netherlands (1)
Adele Diamond, PhD (1) · Babak Azizzadeh, MD, FACS (1) · Carlos Santana, MD (1) · Dustin C. Lee, PhD (1) · Emily K Lindsay, PhD (1) · James Carmody, PhD (1) · James L Abelson, MD (1) · Janice Kiecolt-Glaser, PhD (1) · Joan E. Fox, PhD (1) · Jocelyn Y. Ang, MD (1) · Kenneth Peters, MD (1) · Keren Bachi, PhD (1) · Leslie E. Korn, PhD, MPH (1) · Linda K Larkey, PhD (1)
PMID 18178322, PMID 21372745, PMID 34562208, PMID 35553414
K01AT011232 (1), R01DA027232 (1), R01DA037285 (1), R01MH139940 (1), R21AT002910 (1)