22 completed, 5 unknown, 4 recruiting, 2 not yet recruiting. 11 Not applicable, 2 Phase 1, 2 Phase 2, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 9, Unknown 2 |
| Phase 1 | 2 | Completed 2 |
| Phase 2 | 2 | Completed 2 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Facial Expression: new trials by email Literature Review of Facial Expression trials Research Report on Facial Expression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Validation of the French Version of the SERQoL Questionnaire Smile, Smile Esthetics | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 120 | 2026-01-01 | 2026-01-28 | |
| Developing a Multimodal Cancer Pain Database to Support AI-Based Automatic Pain Assessment Audiovisual and questionnaire-based data collection (once), Audiovisual and questionnaire-based data collection (consecutive) - Cancer-related Pain, Pain Assessment | Recruiting | Dr. Mark Mulder | 200 | 2025-12-01 | 2026-03-11 | |
| Analysis of Facial Expressions for Pain Recognition in Fibromyalgia: Using Artificial Intelligence and Biomarkers Fibromyalgia (FM), Pain | Recruiting | Faculdade de Ciências Médicas de Minas Gerais | 122 | 2025-11-17 | 2025-11-19 | |
| The FACIAL Study Pilot Maximal Exercise Test - Healthy Adult | Not yet recruiting | Lancaster University | 15 | 2025-06-01 | 2025-06-08 | |
| Impact of OnabotulinumtoxinA (BOTOX®) on Stress Intramuscular injection, OnabotulinumtoxinA (Botox®) Injections, Sodium Chloride - Stress (Psychology), Stress | Phase 1 | Completed | Center for Advanced Facial Plastic Surgery | 4 | 2025-03-19 | 2026-04-29 |
| 5 Year Follow up of SMILE® Procedure for the Correction of Hyperopia Hyperopia | Enrolling by invitation | Gemini Eye Clinic | 100 | 2025-01-01 | 2025-08-21 | |
| Analysis of Influencing Factors of High-Order Aberrations of SMILE With Lenticule Retained Small-incision Lenticule Extraction (SMILE) Surgery, Corneal Higher-order Wavefront Aberrations | Recruiting | Second Affiliated Hospital of Nanchang University | 33 | 2024-10-31 | 2026-04-22 | |
| Preliminary Research Using Artificial Intelligence Technology to Identify Differences in Facial Expressions Between Healthy People, Patients With Cognitive Decline, and Patients With Dementia Artificial Intelligence Technology, Cognitive Decline | Unknown | National Taiwan University Hospital | 60 | 2024-09-01 | 2025-04-15 | |
| Efficiency of Sonic Activation During Root Canal Treatment of Primary Molars on Postoperative Pain and Facial Expressions Root canal treatment in primary molars with irreversible pulpitis, EDDY system for sonic activation of irrigation, side-vented needle - Root Canal Treatment in Children Primary Molars, Postoperative Pain | Not applicable | Completed | Suez Canal University | 30 | 2024-08-01 | 2025-09-12 |
| Potential Risk Factors and Predictive Model Construction of OBL During SMILE Small incision lenticule extraction - Myopia, Small-incision Lenticule Extraction (SMILE) Surgery | Completed | Second Affiliated Hospital of Nanchang University | 4678 | 2024-05-01 | 2024-08-29 | |
| Combined Treatment With Pulsed Light and Photobiomodulation Before Laser Refractive Surgery IPL+LLLT - Dry Eye, Dry Eye After LASIK-Laser in Situ Keratomileusis | Not applicable | Completed | University Hospital, Brest | 62 | 2023-06-06 | 2026-01-05 |
| The Effect of Periodontal Health on Smile Periodontal health and gingivitis - Smiling, Gingival Diseases | Completed | Abant Izzet Baysal University | 108 | 2023-05-15 | 2025-02-04 | |
| Artificial Intelligence to Evaluate Postoperative Pain Based on Facial Expression taking a picture of a painful facial expression - Artificial Intelligence, Facial Expression | Unknown | Seoul National University Bundang Hospital | 120 | 2022-06-17 | 2022-07-28 | |
| First Impressions and Attractiveness Levels of Smiling Individuals With and Without a Mask First Impressions, Attractiveness | Completed | DeNova Research | 808 | 2022-03-04 | 2022-04-25 | |
| Split-face Study: Cosmetic Botulinum Toxin Type A Injection Under Electromyography-guidance Versus Conventional Palpation Technique Electromyography-Needle Intramuscular Drug guidance, Botulinum toxin type A - Glabellar Frown Lines, Rhytides | Not applicable | Completed | Mohamed Hayder Oleish Salih | 15 | 2021-08-09 | 2022-08-26 |
| Diagnostic Efficacy of CNN in Predicting Intraoperative Complications and Postoperative Outcomes in SMILE AI diagnostic algorithm - Deep Convolutional Neural Network, Small-incision Lenticule Extraction (SMILE) Surgery | Recruiting | Second Affiliated Hospital of Nanchang University | 1250 | 2021-06-15 | 2026-04-24 | |
| Comparison of the Effects of Two Frequencies of Application of Photobiomodulation on Facial Rejuvenation Photobiomodulation twice a week, Photobiomodulation three times a week, Simulated Photobiomodulation - Wrinkle, Facial Expression | Not applicable | Completed | University of Nove de Julho | 95 | 2021-05-30 | 2024-09-19 |
| Factor Analysis of Unintended Initial Dissection of the Posterior Plane Small incision lenticule extraction - Myopia, Small-incision Lenticule Extraction (SMILE) Surgery | Completed | Yifeng Yu | 3003 | 2021-04-01 | 2022-05-10 | |
| Analysis of the Results of Intense Pulsed Light Treatment Previously to Laser Refractive Surgery Study group, Control group - Meibomian Gland Dysfunction, Blepharitis | Not applicable | Unknown | Vissum, Instituto Oftalmológico de Alicante | 60 | 2021-02-15 | 2022-10-18 |
| Application of Botulinum Toxin at the Yonsei Point for the Treatment of Gummy Smile the injection of onabotulinumtoxinA at different point - Smiling, Botulinum Toxins, Type A | Not applicable | Completed | Peking University | 48 | 2020-10-17 | 2021-11-16 |
Showing 20 of 35. Sign in to see all of them.
Smiling (17) · Autism Spectrum Disorder (3) · Autistic Disorder (3) · Communication (2) · Motor Activity (2) · Myopia (2) · Pain, Postoperative (2) · Agnosia (1) · Anxiety Disorders (1) · Blepharitis (1) · Cancer Pain (1) · Cerebellar Ataxia (1) · Cerebellar Diseases (1) · Cognitive Dysfunction (1)
Behavior (35) · Nonverbal Communication (35) · Communication (33) · Pathological Conditions, Signs and Symptoms (8) · Mental Disorders (7) · Nervous System Diseases (6) · Neurologic Manifestations (6) · Signs and Symptoms (6) · Eye Diseases (5) · Pathologic Processes (4) · Brain Diseases (3) · Central Nervous System Diseases (3) · Child Development Disorders, Pervasive (3) · Neurodevelopmental Disorders (3)
Botulinum Toxins, Type A (3) · Botulinum Toxins (1) · Control Groups (1) · Deep Brain Stimulation (1) · Diagnostic Imaging (1) · Injections (1) · Injections, Intramuscular (1) · Intense Pulsed Light Therapy (1) · Magnetic Resonance Spectroscopy (1) · Oxytocin (1) · Propofol (1) · Sodium Chloride (1) · Therapeutics (1) · incobotulinumtoxinA (1)
Peking University (3) · Second Affiliated Hospital of Nanchang University (3) · University of Florida (2) · Abant Izzet Baysal University (1) · Arkansas Children's Hospital Research Institute (1) · Assistance Publique - Hôpitaux de Paris (1) · Center for Advanced Facial Plastic Surgery (1) · Chang Gung Memorial Hospital (1) · DeNova Research (1) · Dr. Mark Mulder (1) · Faculdade de Ciências Médicas de Minas Gerais (1) · Gemini Eye Clinic (1) · Holland Bloorview Kids Rehabilitation Hospital (1) · Jessica Brian (1) · Kırıkkale University (1)
China (7) · United States (6) · Brazil (4) · Canada (2) · Egypt (2) · France (2) · Taiwan (2) · Turkey (Türkiye) (2) · United Kingdom (2) · Czechia (1) · Germany (1) · Netherlands (1) · South Korea (1) · Spain (1)
Alejandra Rodriguez, MSc, PhD (1) · Aline B Costa, DDS (1) · Anke Messerschmidt-Roth, Dr. rer. medic. (1) · Azra Bihorac, MD (1) · Babak Azizzadeh, MD, FACS (1) · Chia-Ling Chen, MD, PhD (1) · Daniel S Pine, M.D. (1) · Dinete Romansina, MSc (1) · Ghada Abdelhamid El-Baz, Professor of Pedodontics (1) · Gregory L Kearns, PharmD, PhD (1) · Helena Matus, MD (1) · Jessica Brian, PhD (1)
PMID 11097583, PMID 11311627, PMID 17216074, PMID 20712970, PMID 26989003, PMID 28574669, PMID 29688838, PMID 30481814, PMID 31073600, PMID 32182637, PMID 32188437, PMID 35056370, PMID 36749255, PMID 38150126, PMID 38176698, PMID 40167796, PMID 41748188
R01NS120924 (1), R21AG044449 (1), R21EB027344 (1)